SEN12333 | WAY-317538 | α7 nAChR Agonist | AmBeed-信号通路专用抑制剂

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SEN12333 {[allProObj[0].p_purity_real_show]}

货号：A1169631 同义名： WAY-317538

SEN12333是一种选择性 α7 烟碱型乙酰胆碱受体（nAChR）激动剂，对大鼠的 EC50 和 Ki 值分别为 1.6 μM 和 260 nM，同时在组胺 H3 受体上具有功能性拮抗作用（IC50 = 103 nM）。

SEN12333 化学结构
CAS号：874450-44-9

SEN12333 3D分子结构
CAS号：874450-44-9

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SEN12333 纯度/质量文件产品仅供科研

货号：A1169631 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

AChR 亚型比较
组胺受体亚型比较

产品名称	AChE ↓ ↑	AChR ↓ ↑	mAChR ↓ ↑	nAChR ↓ ↑	其他靶点	纯度
Donepezil	+++ hAChE, IC50: 11.6 nM bAChE, IC50: 8.12 nM					98%
Loganin	++ AChE, IC50: 3.95 μM					99%+
topride HCl	++ AChE, IC50: 2.04 μM					98%
Dehydroevodiamine HCl	✔					99%+
Jatrorrhizine	++ AChE, IC50: 872 nM					99%+
Palmatine	++ AChE, IC50: 0.51 μM					98%
(-)-Huperzine A	++++ AChE (G4 form), Ki: 7 nM					98%
Galanthamine HBr	++ AChE, IC50: 0.35 μM					98%
Trospium chloride		✔				99%
Tiotropium Bromide Monohydrate		✔				98+%
Gallamine Triethiodide		+ AChR, IC50: 68.0 μM				98%
Hexamethonium Bromide		✔				99%
Pancuronium dibromide		✔				98%
Neostigmine bromide		✔				98%
Orphenadrine citrate		✔				98%
Oxybutynin		✔				98%
Irsogladine		✔			PDE	99%
Pyridostigmine bromide		✔				99+%
Rivastigmine		+ AChR, IC50: 5.5 μM				98%
Paroxetine hydrochloride		✔				99%
Rocuronium Bromide		✔				98%
Tropicamide			+++ M4 mAChR, IC50: 8 nM			98%
Diphenmanil methylsulfate			✔			99%
Umeclidinium bromide			✔			95%
Otilonium bromide			✔			98%
Flavoxate HCl			+ mAChR, IC50: 12.2 μM			99%
Ipratropium bromide			✔			98%
Diphenidol HCl			✔			98%
Darifenacin hydrobromide			++++ M3 mAChR, pKi: 8.9			98%
Aclidinium Bromide			++++ M4 mAChR, Ki: 0.21 nM M2 mAChR, Ki: 0.1 nM			98%
Oxybutynin chloride			✔			99%
Pentoxyverine citrate			✔			98%
Solifenacin			✔			98%
Catharanthine				✔		98%
Benzethonium chloride				+++ α7 nAChRs, IC50: 122 nM α4β2 nAChRs, IC50: 49 nM		99+%
Vinblastine sulfate				+ nAChR, IC50: 8.9 μM		99%
PNU-120596				++ α7 nAChR, EC50: 216 nM		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	H1 receptor ↓ ↑	H2 receptor ↓ ↑	H3 receptor ↓ ↑	H4 receptor ↓ ↑	Histamine receptor ↓ ↑	其他靶点	纯度
Hydroxyzine 2HCl							99+%
Cyclizine	✔						97%
Loratadine	+ B(0)AT2, IC50: 4 μM						98%
Desloratadine	++ Histamine H1 receptor, IC50: 51 nM						98%
Doxylamine succinate	✔						99%
Ebastine	✔						98%
Tripelennamine HCl	+ H1 receptor, IC50: 30 μM						98%
Meclizine dihydrochloride	✔						98%
Chlorpheniramine maleate	+++ Histamine H1 receptor, IC50: 12 nM						99%
Diphenhydramine HCl	✔						99%
Alcaftadine	++++ H1 receptor, pKi: 8.5	++ H2 receptor, pKi: 7.2					99%+
Fexofenadine HCl	++ Histamine H1 receptor, IC50: 246 nM						99%+
Bilastine	+++ H1 receptor, Ki: 44.15 nM						98%
Pemirolast potassium	✔						98%
Bepotastine besilate	+ Histamine H1 receptor, pIC50: 5.7						98%
Mizolastine	+++ Histamine H1 receptor, IC50: 47 nM						98%
Brompheniramine maleate	✔						98%
Carbinoxamine maleate salt	✔						99+%
Clemastine fumarate	++++ Histamine H1 receptor, IC50: 3 nM						98%
Ketotifen fumarate salt	✔						95%
Rupatadine Fumarate	++ Histamine H1 receptor, Ki: 102 nM					PAFR	98%
Famotidine		✔					97%
Roxatidine Acetate HCl		+ Histamine H2 receptor, IC50: 3.2 μM					98%
Lafutidine		✔					99%
Cimetidine		✔					98%
Nizatidine		++++ Histamine H2 receptor, IC50: 0.9 nM				AChE	98%
Ranitidine		✔					98%
Betahistine			+ Histamine H3 receptor, IC50: 1.9 μM				99%
Ciproxifan maleate			+++ Histamine H3 receptor, IC50: 9.2 nM				99%+
S 38093			++ human H3 receptor, Ki: 1.2 μM rat H3 receptor, Ki: 1.44 μM				98%
JNJ-7777120				++++ Histamine H4 receptor, Ki: 4.5 nM			99%
Azelastine HCl					✔		98%
Epinastine HCl					✔		99%
Levodropropizine					✔		97%
Cyproheptadine hydrochloride					✔		98%
Hesperetin					✔		97%
Olopatadine HCl					✔		98%
Mianserin hydrochloride					✔		99+%
Buclizine 2HCl					✔		97%
Latrepirdine 2HCl					✔	GluR	99%
Cetirizine 2HCl					✔		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

SEN12333 生物活性

描述

SEN12333 is a potent, selective and orally active α7 nAChR agonist. SEN12333 has a high affinity for rat α7 nAChRs expressed in GH4C1 cells (Ki=260 nM) and acts as a full agonist in functional Ca²⁺ flux studies (EC50=1.6 μM). SEN 12333 was used in attention deficit disorder and schizophrenia studies. In whole-cell patch-clamp recordings, SEN12333 activated peak currents and maximum total charge similar to acetylcholine (EC50= 12 μM). SEN12333 has functional antagonistic effects on histamine H3 receptor (IC50=103 nM), and on the human ganglionic α3 nAChRs with weak agonistic activity (IC50= 8.5 μM)^[1].

SEN12333 动物研究

Animal study

Administered intraperitoneally at a dose of 3 mg/kg, SEN12333 improves episodic memory in rats during spontaneous amnesia as well as during a novel object recognition task in the presence of cognitive disturbances induced by glutamatergic or cholinergic mechanisms. SEN12333 also prevents memory deficits in a scopolamine-induced passive avoidance task^[1].

SEN12333 参考文献

[1]Corinne Beinat, et al. The Recent Development of α7 Nicotinic Acetylcholine Receptor (nAChR) Ligands as Therapeutic Candidates for the Treatment of Central Nervous System (CNS) Diseases.Curr Pharm Des. 2016;22(14):2134-51.

SEN12333 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.46mL

5.89mL

2.95mL

SEN12333 技术信息

CAS号	874450-44-9
分子式	C₂₀H₂₅N₃O₂
分子量	339.431

别名	WAY-317538
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature

溶解度

DMSO: 105 mg/mL(309.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

SEN12333 {[allProObj[0].p_purity_real_show]}

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SEN12333 纯度/质量文件 产品仅供科研

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最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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