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盐酸奥昔布宁 /Oxybutynin chloride {[allProObj[0].p_purity_real_show]}

货号：A586213 同义名： Oxybutynin hydrochloride;Oxybutynin (hydrochloride)

Oxybutynin HCl a synthetic anticholinergic agent used for treatment of urinary incontinence and overactive bladder syndrome, with elimination half-life of ‎12.4–13.2 hours. Oxybutynin HCl is the HCl form of Oxybutynin.

Oxybutynin chloride 化学结构 CAS号：1508-65-2
Oxybutynin chloride 化学结构
CAS号：1508-65-2
Oxybutynin chloride 3D分子结构
CAS号：1508-65-2
Oxybutynin chloride 化学结构 CAS号：1508-65-2
Oxybutynin chloride 3D分子结构 CAS号：1508-65-2
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Oxybutynin chloride 纯度/质量文件 产品仅供科研

货号：A586213 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

hAChE, IC50: 11.6 nM

bAChE, IC50: 8.12 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 98%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine hydrochloride ✔ 97%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 98%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		98%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Oxybutynin chloride 生物活性

靶点

  • mAChR
描述 Oxybutynin HCl is an anticholinergic agent. Oxybutynin inhibited vascular Kv channels in a concentration-dependent manner, with an IC50 value of 11.51 ± 0.38 μmol/L and a Hill coefficient (n) of 2.25 ± 0.12. Oxybutynin inhibited the vascular Kv current in a concentration-dependent manner by influencing the steady-state activation and inactivation curves independent of its anticholinergic effect[3]. The majority of the patients (88.2%) with IBSF (inadequate bladder storage function) were responsive to the 15-mg daily oxybutynin HCl. Oxybutynin HCl in sufficient dosages seems to be effective in the treatment of enuretic patients with IBSF[4]. Oxybutynin seems promising in the management of hot flashes with tolerable side effects in the majority of refractory patients[5]. Oxybutynin 3% gel reduced hyperhidrosis severity and improved health-related quality of life in this small pilot study[6].

Oxybutynin chloride 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02386072 - Completed - -
NCT00547378 Urinary Incontinence, Urgency-... 展开 >>frequency Overactive Bladder 收起 << Phase 4 Completed - -
NCT00366002 Overactive Bladder (OAB) Phase 4 Completed - -

Oxybutynin chloride 参考文献

[1]Anderson RU, Mobley D, et al. Once daily controlled versus immediate release oxybutynin chloride for urge urinary incontinence. OROS Oxybutynin Study Group. J Urol. 1999 Jun;161(6):1809-12.

[2]Yarker YE, Goa KL, et al. Oxybutynin. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic use in detrusor instability. Drugs Aging. 1995 Mar;6(3):243-62.

[3]Li H, Seo MS, An JR, et al. The anticholinergic drug oxybutynin inhibits voltage-dependent K+ channels in coronary arterial smooth muscle cells. Clin Exp Pharmacol Physiol. 2019;46(11):1030-1036

[4]Koşar A, Arikan N, Dinçel C. Effectiveness of oxybutynin hydrochloride in the treatment of enuresis nocturna--a clinical and urodynamic study. Scand J Urol Nephrol. 1999;33(2):115-118

[5]Sexton T, Younus J, Perera F, Kligman L, Lock M. Oxybutynin for refractory hot flashes in cancer patients. Menopause. 2007;14(3 Pt 1):505-509

[6]Nguyen NV, Gralla J, Abbott J, Bruckner AL. Oxybutynin 3% gel for the treatment of primary focal hyperhidrosis in adolescents and young adults. Pediatr Dermatol. 2018;35(2):208-212

Oxybutynin chloride 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.69mL

2.54mL

1.27mL

25.38mL

5.08mL

2.54mL

Oxybutynin chloride 技术信息

CAS号1508-65-2
分子式C22H32ClNO3
分子量 393.947
别名 Oxybutynin hydrochloride;Oxybutynin (hydrochloride);MJ4309-1
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 105 mg/mL(266.53 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(76.15 mM)，配合低频超声助溶
动物实验配方

Tags: Oxybutynin | 1508-65-2 | mAChR Antagonist | GPCR/G Protein | Neuronal Signaling | Membrane Transporter/Ion Channel | mAChR | Potassium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Oxybutynin chloride 纯度/质量文件 | Oxybutynin chloride 亚型比较 | Oxybutynin chloride 生物活性 | Oxybutynin chloride 临床数据 | Oxybutynin chloride 参考文献 | Oxybutynin chloride 实验方案 | Oxybutynin chloride 技术信息

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