Coclaurine, a natural product isolated and purified from the root of Coptis chinensis Franch, blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.

nAChR agonist 1 is a novel positive allosteric modulator of α7 nAChR. It has shown excellent safety profile in phase 1 clinical trials and is being evaluated for efficacy and safety as monotherapy in patients with mild to moderate Alzheimer’s disease.

Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

EVP-6124 is a partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) and shows selectivity for α7 nAChRs and did not activate or inhibit heteromeric α4β2 nAChRs.

N-Methylcytisine's nicotinic receptors have high affinity (KD = 50 nM)to nAChR from squid optical ganglia.

Arecaidine but-2-ynyl ester tosylate is a potent muscarinic agonist that shows 4.6-fold that is selectivity for mAChR M2 in the atrium versus those in the ileum.

VU0152100 is a potent and selective allosteric potentiator of M4 mAChR.

Mepenzolate bromide mAchR antagonist, working as a post-ganglionic parasympathetic inhibitor to decrease gastric acid and pepsin secretion and suppresse spontaneous contractions of the colon.

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell.

Nitenpyram is a nAchR agonist, used an antiparasitic drug.

Vecuronium bromide is a competitive AchR inhibitor and binds to cholinergic receptors at neuromuscular junctions, used as an aminosteroidal neuromuscular blocking agent.

Dinotefuran is the third generation of neonicotinoid group,which works through inhibiting nAchRs.

Methylbenactyzium Bromide is a mAchR antagonist, used as a spasmolytic for the treatment of gastrointestinal ulcer and gastrointestinal spasms.

Pirenzepine 2HCl is a is an anticholinergic agent and induces the dimerization of muscarinic M1 receptors, used to treat myopia, gastric and duodenal ulcers.

Imidafenacin is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM and less potent for M2 receptors (IC50=4.13 nM).

Spinosad是一种广谱杀虫剂，主要用于控制农业害虫。Spinosad 靶向昆虫神经系统的烟碱乙酰胆碱受体 (nAChRs)。它通过干扰昆虫的神经系统，具有高效的昆虫控制能力，在农业研究和应用中广泛使用。

VU0467485（AZ13713945）是一种有效的、选择性的、口服可用的正向变构调节剂（PAM），对乙酰胆碱受体4（M4）具有作用。VU0467485在中枢神经系统中有中等到高的渗透性，并具有类抗精神病活性。

Nebracetam hydrochloride是一种 M1 毒蕈碱受体的激动剂，能使细胞内 Ca2+ 浓度增加，其 EC50 值为 1.59 mM。

4BP-TQS是一种有效的 α7 nAChR 变构激动剂，通过变构跨膜位点激活 nAChRs。

S 24795是 α7 nAChR 的部分激动剂，可以改善衰老小鼠的记忆功能，用于衰老相关记忆障碍的研究。