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首页 / 抑制剂/激动剂 / 神经信号通路 / AChR / Gallamine Triethiodide

三碘季胺酚 /Gallamine Triethiodide {[allProObj[0].p_purity_real_show]}

货号：A616170 同义名： 加拉碘铵 / Gallamine (iodide)

Gallamine triethiodide is a competitive cholinergic receptor blocker with an IC50 of 68.0 ± 8.4 μM, used as a non-depolarising muscle relaxant.

Gallamine Triethiodide 化学结构 CAS号：65-29-2
Gallamine Triethiodide 化学结构
CAS号：65-29-2
Gallamine Triethiodide 3D分子结构
CAS号：65-29-2
Gallamine Triethiodide 化学结构 CAS号：65-29-2
Gallamine Triethiodide 3D分子结构 CAS号：65-29-2
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Gallamine Triethiodide 纯度/质量文件 产品仅供科研

货号：A616170 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 98%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine hydrochloride ✔ 97%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 98%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		98%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α7 nAChRs, IC50: 122 nM

α4β2 nAChRs, IC50: 49 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Gallamine Triethiodide 生物活性

靶点

  • AChR

    AChR, IC50:68.0 μM
描述 Gallamine Triethiodine is a cholinergic receptor inhibitor. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. Gallamine triethiodide has a parasympatholytic effect on the cardiac vagus nerve which causes tachycardia and occasionally hypertension. Very high doses cause histamine release[3]. Internal gallamine triethiodide modifies Na+ channel kinetics in Myxicola axons but does not alter K+ conductance[4]. Slight accumulation of gallamine was noted in two of the four patients with biliary disease receiving multiple doses of gallamine, but this was also characteristic of data obtained in the patients without obstruction[5].

Gallamine Triethiodide 参考文献

[1]Abbas MN, Mostafa GA. Gallamine-tetraphenylborate-modified carbon paste electrode for the potentiometric determination of gallamine triethiodide(flaxedil). J Pharm Biomed Anal. 2003 Mar 26;31(4):819-26.

[2]Nedoma J, Tucek S, et al. Stabilization of antagonist binding to cardiac muscarinic acetylcholine receptors by gallamine and other neuromuscular blocking drugs. J Pharmacol Exp Ther. 1986 Jan;236(1):219-23.

[3]SMITH RH, THOMAS DL. Gallamine triethiodide as an adjunct to electroplexy. Br Med J. 1951 Apr 21;1(4711):860-2.

[4]Schauf CL, Smith KJ. Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons. J Physiol. 1982 Feb;323:157-71.

[5]Ramzan IM, Shanks CA, Triggs EJ. Pharmacokinetics and pharmacodynamics of gallamine triethiodide in patients with total biliary obstruction. Anesth Analg. 1981 May;60(5):289-96.

Gallamine Triethiodide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.12mL

0.22mL

0.11mL

5.61mL

1.12mL

0.56mL

11.22mL

2.24mL

1.12mL

Gallamine Triethiodide 技术信息

CAS号65-29-2
分子式C30H60I3N3O3
分子量 891.529
别名 加拉碘铵 ;Gallamine (iodide)
运输蓝冰
存储条件

液体 -20°C:1个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C
溶解度

H2O: 30 mg/mL(33.65 mM)
动物实验配方

Tags: Gallamine Triethiodide | Gallamine (iodide) | 加拉碘铵 | AChR | AmBeed-信号通路专用抑制剂 | Gallamine Triethiodide 纯度/质量文件 | Gallamine Triethiodide 亚型比较 | Gallamine Triethiodide 生物活性 | Gallamine Triethiodide 参考文献 | Gallamine Triethiodide 实验方案 | Gallamine Triethiodide 技术信息

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