多奈哌齐 /Donepezil
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货号：A127504
同义名：
多萘哌齐碱
/ E2020 free base;Aricept
Donepezil is a centrally acting reversible AchE inhibitor with IC50 of 8.12 nM and 11.6 nM for bAChE and hAChE, respectively, a medication used to treat Alzheimer's disease.
Donepezil 化学结构
Donepezil 3D分子结构
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Donepezil 纯度/质量文件 产品仅供科研
货号：A127504
标准纯度：
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Donepezil 质控信息
Donepezil 生物活性
靶点
AChE
hAChE, IC50:11.6 nM
bAChE, IC50:8.12 nM
描述
Donepezil, as a acetylcholinesterase (AChE) inhibitors, inhibits AChE activity thereby increasing the acetylcholine (ACh) levels. Pretreatment with donepezil suppressed the TNFα-induced sustained intracellular Ca2+ elevation in both rat HAPI and mouse primary microglial cells[3] [4] [5]
Donepezil 参考文献
[1] Ogura H, Kosasa T, et al. Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro. Methods Find Exp Clin Pharmacol. 2000 Oct;22(8):609-13.
[2] Snape MF, Misra A, et al. A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066. Neuropharmacology. 1999 Jan;38(1):181-93.
[3] Haraguchi Y, Mizoguchi Y, Ohgidani M, Imamura Y, Murakawa-Hirachi T, Nabeta H, Tateishi H, Kato TA, Monji A. Donepezil suppresses intracellular Ca2+ mobilization through the PI3K pathway in rodent microglia. J Neuroinflammation. 2017 Dec 22;14(1):258. doi: 10.1186/s12974-017-1033-0. PMID: 29273047; PMCID: PMC5741946.
[4] Li K, Cheng N, Li XT. Inhibitory effects of cholinesterase inhibitor donepezil on the Kv1.5 potassium channel. Sci Rep. 2017 Feb 13;7:41509. doi: 10.1038/srep41509. PMID: 28198801; PMCID: PMC5304190.
[5] Yu TS, Kim A, Kernie SG. Donepezil rescues spatial learning and memory deficits following traumatic brain injury independent of its effects on neurogenesis. PLoS One. 2015 Feb 25;10(2):e0118793. doi: 10.1371/journal.pone.0118793. PMID: 25714524; PMCID: PMC4340948.
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Donepezil 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.64mL
0.53mL
0.26mL
13.18mL
2.64mL
1.32mL
26.35mL
5.27mL
2.64mL
Donepezil 技术信息
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