SEN12333

产品说明书

Print
Chemical Structure| 874450-44-9 同义名 : WAY-317538
CAS号 : 874450-44-9
货号 : A1169631
分子式 : C20H25N3O2
纯度 : 99%+
分子量 : 339.431
MDL号 : MFCD17167027
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(309.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SEN12333 is a potent, selective and orally active α7 nAChR agonist. SEN12333 has a high affinity for rat α7 nAChRs expressed in GH4C1 cells (Ki=260 nM) and acts as a full agonist in functional Ca2+ flux studies (EC50=1.6 μM). SEN 12333 was used in attention deficit disorder and schizophrenia studies. In whole-cell patch-clamp recordings, SEN12333 activated peak currents and maximum total charge similar to acetylcholine (EC50= 12 μM). SEN12333 has functional antagonistic effects on histamine H3 receptor (IC50=103 nM), and on the human ganglionic α3 nAChRs with weak agonistic activity (IC50= 8.5 μM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.95mL

0.59mL

0.29mL

14.73mL

2.95mL

1.47mL

29.46mL

5.89mL

2.95mL
参考文献

[1]Corinne Beinat, et al. The Recent Development of α7 Nicotinic Acetylcholine Receptor (nAChR) Ligands as Therapeutic Candidates for the Treatment of Central Nervous System (CNS) Diseases.Curr Pharm Des. 2016;22(14):2134-51.