盐酸依托必利 /topride HCl
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货号：A953061
同义名：
盐酸伊托必利
/ HSR803;Itopride (hydrochloride)
Itopride HCl is a D2 antagonist and an AChE inhibitor with an IC50 value of 2.04±0.27 μM. It is a prokinetic benzamide derivative unlike domperidone.
topride HCl 化学结构
topride HCl 3D分子结构
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topride HCl 纯度/质量文件 产品仅供科研
货号：A953061
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topride HCl 质控信息
topride HCl 生物活性
靶点
描述
Itopride hydrochloride (itopride) inhibits acetylcholinesterase (AChE) and antagonizes dopamine D2 receptor, and has been used as a gastroprokinetic agent. In the ileum, itopride accelerated peristaltic velocity at higher dosage (10-10 -10-6 M) and significantly shortened colonic transit[3] [4]
topride HCl 参考文献
[1] Scarpellini E, Vos R, et al. The effects of itopride on oesophageal motility and lower oesophageal sphincter function in man. Aliment Pharmacol Ther. 2011 Jan;33(1):99-105.
[2] Iwanaga Y, Kimura T, et al. Characterization of acetylcholinesterase-inhibition by itopride. Jpn J Pharmacol. 1994 Nov;66(3):317-22.
[3] Lim HC, Kim YG, Lim JH, Kim HS, Park H. Effect of itopride hydrochloride on the ileal and colonic motility in guinea pig in vitro. Yonsei Med J. 2008 Jun 30;49(3):472-8.
[4] Kim YS, Kim TH, Choi CS, Shon YW, Kim SW, Seo GS, Nah YH, Choi MG, Choi SC. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005 Jul 21;11(27):4210-4.
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topride HCl 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
2.53mL
0.51mL
0.25mL
12.66mL
2.53mL
1.27mL
25.32mL
5.06mL
2.53mL
topride HCl 技术信息
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