盐酸地芬尼多 /Diphenidol HCl
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货号：A191183
同义名：
Difenidol hydrochloride;Diphenidol (hydrochloride)
Diphenidol HCl is a non-selective mAchR antagonist and also works as a non-specific inhibitor of voltage-gated ion channels (Na+, K+, and Ca2+) in neurons.
Diphenidol HCl 化学结构
Diphenidol HCl 3D分子结构
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Diphenidol HCl 纯度/质量文件 产品仅供科研
货号：A191183
标准纯度：
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Diphenidol HCl 质控信息
Diphenidol HCl 生物活性
靶点
描述
Diphenidol hydrochloride is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. Diphenidol exhibited a concentration- and state-dependent effect on tonic blockade of voltage-gated Na+ currents in mouse neuroblastoma N2A cells (IC50 of 0.77 and 62.6 mM at holding potentials of -70 and -100 mV, respectively)[3] + channels, which are associated with specific types of pain.Systemic diphenidol produced a dose-related inhibition of mechanical allodynia following chronic constriction injury of the sciatic nerve[4]
Diphenidol HCl 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT01574313
Vertigo
Menie... 展开 >> re Disease 收起 <<
Phase 4
Completed
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Taiwan
... 展开 >> i Mei Medical Center Tainan, Taiwan, Taiwan
Tainan, Taiwan, 70014 收起 <<
Diphenidol HCl 参考文献
[1] Leung YM, Wong KL, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44.
[2] Leung YM, Wu BT, Chen YC, Hung CH, Chen YW. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.
[3] Leung YM, Wu BT, Chen YC, Hung CH, Chen YW. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52. doi: 10.1016/j.neuropharm.2010.02.007. Epub 2010 Feb 20.
[4] Chen YW, Tzeng JI, Liu KS, Yu SH, Hung CH, Wang JJ. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5.
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Diphenidol HCl 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.89mL
0.58mL
0.29mL
14.45mL
2.89mL
1.45mL
28.91mL
5.78mL
2.89mL
Diphenidol HCl 技术信息
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