Diphenidol HCl | Difenidol hydrochloride | Muscarinic M1-4 Receptor Antagonist

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盐酸地芬尼多 /Diphenidol HCl 98%

货号：A191183 同义名： Difenidol hydrochloride;Diphenidol (hydrochloride)

Diphenidol HCl is a non-selective mAchR antagonist and also works as a non-specific inhibitor of voltage-gated ion channels (Na+, K+, and Ca2+) in neurons.

Diphenidol HCl 化学结构
CAS号：3254-89-5

Diphenidol HCl 3D分子结构
CAS号：3254-89-5

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Diphenidol HCl 纯度/质量文件产品仅供科研

货号：A191183 标准纯度： 98% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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AChR 亚型比较

产品名称	AChE ↓ ↑	AChR ↓ ↑	mAChR ↓ ↑	nAChR ↓ ↑	其他靶点	纯度
Donepezil	+++ bAChE, IC50: 8.12 nM hAChE, IC50: 11.6 nM					98%
Loganin	++ AChE, IC50: 3.95 μM					99%+
topride HCl	++ AChE, IC50: 2.04 μM					98%
Dehydroevodiamine HCl	✔					99%+
Jatrorrhizine	++ AChE, IC50: 872 nM					99%+
Palmatine	++ AChE, IC50: 0.51 μM					98%
(-)-Huperzine A	++++ AChE (G4 form), Ki: 7 nM					98%
Galanthamine HBr	++ AChE, IC50: 0.35 μM					98%
Trospium chloride		✔				99%
Tiotropium Bromide Monohydrate		✔				98+%
Gallamine Triethiodide		+ AChR, IC50: 68.0 μM				98%
Hexamethonium Bromide		✔				99%
Pancuronium dibromide		✔				98%
Neostigmine bromide		✔				98%
Orphenadrine citrate		✔				98%
Oxybutynin		✔				98%
Irsogladine		✔			PDE	98%
Pyridostigmine bromide		✔				99+%
Rivastigmine		+ AChR, IC50: 5.5 μM				98%
Paroxetine hydrochloride		✔				97%
Rocuronium Bromide		✔				98%
Tropicamide			+++ M4 mAChR, IC50: 8 nM			98%
Diphenmanil methylsulfate			✔			98%
Umeclidinium bromide			✔			95%
Otilonium bromide			✔			98%
Flavoxate HCl			+ mAChR, IC50: 12.2 μM			98%
Ipratropium bromide			✔			98%
Diphenidol HCl			✔			98%
Darifenacin hydrobromide			++++ M3 mAChR, pKi: 8.9			98%
Aclidinium Bromide			++++ M4 mAChR, Ki: 0.21 nM M2 mAChR, Ki: 0.1 nM			98%
Oxybutynin chloride			✔			99%
Pentoxyverine citrate			✔			98%
Solifenacin			✔			98%
Catharanthine				✔		98%
Benzethonium chloride				+++ α4β2 nAChRs, IC50: 49 nM α7 nAChRs, IC50: 122 nM		99+%
Vinblastine sulfate				+ nAChR, IC50: 8.9 μM		99%
PNU-120596				++ α7 nAChR, EC50: 216 nM		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Diphenidol HCl 生物活性

靶点

mAChR

描述

Diphenidol hydrochloride is a muscarinic antagonist employed as an antiemetic and as an antivertigo agent. Diphenidol exhibited a concentration- and state-dependent effect on tonic blockade of voltage-gated Na⁺ currents in mouse neuroblastoma N2A cells (IC50 of 0.77 and 62.6 mM at holding potentials of -70 and -100 mV, respectively)^[3]. Diphenidol has been shown to block voltage-gated Na⁺ channels, which are associated with specific types of pain.Systemic diphenidol produced a dose-related inhibition of mechanical allodynia following chronic constriction injury of the sciatic nerve^[4].

Diphenidol HCl 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01574313	Vertigo Menie... 展开 >>re Disease 收起 <<	Phase 4	Completed	-	Taiwan ... 展开 >> i Mei Medical Center Tainan, Taiwan, Taiwan Tainan, Taiwan, 70014 收起 <<

Diphenidol HCl 参考文献

[1]Leung YM, Wong KL, et al. Inhibition of voltage-gated K+ channels and Ca2+ channels by diphenidol. Pharmacol Rep. 2012;64(3):739-44.

[2]Leung YM, Wu BT, Chen YC, Hung CH, Chen YW. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52.

[3]Leung YM, Wu BT, Chen YC, Hung CH, Chen YW. Diphenidol inhibited sodium currents and produced spinal anesthesia. Neuropharmacology. 2010 Jun;58(7):1147-52. doi: 10.1016/j.neuropharm.2010.02.007. Epub 2010 Feb 20.

[4]Chen YW, Tzeng JI, Liu KS, Yu SH, Hung CH, Wang JJ. Systemic diphenidol reduces neuropathic allodynia and TNF-alpha overexpression in rats after chronic constriction injury. Neurosci Lett. 2013 Sep 27;552:62-5.

Diphenidol HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.89mL

0.58mL

0.29mL

14.45mL

2.89mL

1.45mL

28.91mL

5.78mL

2.89mL

Diphenidol HCl 技术信息

CAS号	3254-89-5
分子式	C₂₁H₂₈ClNO
分子量	345.906

别名	Difenidol hydrochloride;Diphenidol (hydrochloride);SKF 478A;Diphenidol hydrochloride
运输	蓝冰

存储条件

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 45 mg/mL(130.09 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H₂O: 15 mg/mL(43.36 mM)，配合低频超声助溶

动物实验配方

盐酸地芬尼多 /Diphenidol HCl 98%

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盐酸地芬尼多 /Diphenidol HCl 98%

Diphenidol HCl 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Diphenidol HCl 质控信息

Diphenidol HCl 生物活性

Diphenidol HCl 临床研究

Diphenidol HCl 参考文献

Diphenidol HCl 实验方案

Diphenidol HCl 技术信息

最近浏览的产品

大规格询价

摩尔计算器

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总药量计算器

工作液计算器

细胞研究

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确认信息

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Diphenidol HCl 纯度/质量文件产品仅供科研