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货号:A248225 同义名: ORG 9426 Bromide;Rocuronium (bromide)

Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker.

Rocuronium Bromide 化学结构 CAS号:119302-91-9
Rocuronium Bromide 化学结构
CAS号:119302-91-9
Rocuronium Bromide 3D分子结构
CAS号:119302-91-9
Rocuronium Bromide 化学结构 CAS号:119302-91-9
Rocuronium Bromide 3D分子结构 CAS号:119302-91-9
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Rocuronium Bromide 纯度/质量文件 产品仅供科研

货号:A248225 标准纯度: {[allProObj[0].p_purity_real_show]}
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产品名称 AChE AChR mAChR nAChR 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

98%
Loganin ++

AChE, IC50: 3.95 μM

99%+
topride HCl ++

AChE, IC50: 2.04 μM

98%
Dehydroevodiamine HCl 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

99%+
Palmatine ++

AChE, IC50: 0.51 μM

98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

98%
Trospium chloride 99%
Tiotropium Bromide Monohydrate 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

98%
Hexamethonium Bromide 99%
Pancuronium dibromide 98%
Neostigmine bromide 98%
Orphenadrine citrate 98%
Oxybutynin 98%
Irsogladine PDE 98%
Pyridostigmine bromide 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

98%
Paroxetine hydrochloride 97%
Rocuronium Bromide 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

98%
Diphenmanil methylsulfate 98%
Umeclidinium bromide 95%
Otilonium bromide 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

98%
Ipratropium bromide 98%
Diphenidol HCl 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

98%
Oxybutynin chloride 99%
Pentoxyverine citrate 98%
Solifenacin 98%
Catharanthine 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Rocuronium Bromide 生物活性

靶点
  • AChR

描述 Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia. Rocuronium bromide induced inflammation and pain in CPAE cells[3]. Rocuronium reduced the indirectly elicited twitch tensions in normal (IC50 = 9.84 μM) and all pretreated diaphragms in a concentration-dependent fashion[4]. Rocuronium possesses a very stable cardiovascular profile and a rapid onset of action[5].

Rocuronium Bromide 参考文献

[1]Narimatsu E, Niiya T, et al. Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependent fashion. Am J Emerg Med. 2012 Jul;30(6):901-7.

[2]Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.

[3]Baek SB, Shin MS, Han JH, Moon SW, Chang B, Jeon JW, Yi JW, Chung JY. Rocuronium Bromide Inhibits Inflammation and Pain by Suppressing Nitric Oxide Production and Enhancing Prostaglandin E2 Synthesis in Endothelial Cells. Int Neurourol J. 2016 Dec;20(4):296-303.

[4]Narimatsu E, Niiya T, Takahashi K, Yamauchi M, Yamakage M. Pralidoxime inhibits paraoxon-induced depression of rocuronium-neuromuscular block in a time-dependent fashion. Am J Emerg Med. 2012 Jul;30(6):901-7.

[5]Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.

Rocuronium Bromide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.64mL

0.33mL

0.16mL

8.20mL

1.64mL

0.82mL

16.40mL

3.28mL

1.64mL

Rocuronium Bromide 技术信息

CAS号119302-91-9
分子式C32H53BrN2O4
分子量 609.68
别名 ORG 9426 Bromide;Rocuronium (bromide);(+)-Rocuronium;ORG 9426
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,2-8°C

溶解度

DMSO: 105 mg/mL(172.22 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 100 mg/mL(164.02 mM),配合低频超声助溶

动物实验配方
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