货号:A248225 同义名: ORG 9426 Bromide;Rocuronium (bromide)
Rocuronium bromide is an aminosteroid non-depolarizing neuromuscular blocker.
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产品名称 | AChE ↓ ↑ | AChR ↓ ↑ | mAChR ↓ ↑ | nAChR ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Donepezil |
+++
bAChE, IC50: 8.12 nM hAChE, IC50: 11.6 nM |
98% | |||||||||||||||||
Loganin |
++
AChE, IC50: 3.95 μM |
99%+ | |||||||||||||||||
topride HCl |
++
AChE, IC50: 2.04 μM |
98% | |||||||||||||||||
Dehydroevodiamine HCl | ✔ | 99%+ | |||||||||||||||||
Jatrorrhizine |
++
AChE, IC50: 872 nM |
99%+ | |||||||||||||||||
Palmatine |
++
AChE, IC50: 0.51 μM |
98% | |||||||||||||||||
(-)-Huperzine A |
++++
AChE (G4 form), Ki: 7 nM |
98% | |||||||||||||||||
Galanthamine HBr |
++
AChE, IC50: 0.35 μM |
98% | |||||||||||||||||
Trospium chloride | ✔ | 99% | |||||||||||||||||
Tiotropium Bromide Monohydrate | ✔ | 98+% | |||||||||||||||||
Gallamine Triethiodide |
+
AChR, IC50: 68.0 μM |
98% | |||||||||||||||||
Hexamethonium Bromide | ✔ | 99% | |||||||||||||||||
Pancuronium dibromide | ✔ | 98% | |||||||||||||||||
Neostigmine bromide | ✔ | 98% | |||||||||||||||||
Orphenadrine citrate | ✔ | 98% | |||||||||||||||||
Oxybutynin | ✔ | 98% | |||||||||||||||||
Irsogladine | ✔ | PDE | 98% | ||||||||||||||||
Pyridostigmine bromide | ✔ | 99+% | |||||||||||||||||
Rivastigmine |
+
AChR, IC50: 5.5 μM |
98% | |||||||||||||||||
Paroxetine hydrochloride | ✔ | 97% | |||||||||||||||||
Rocuronium Bromide | ✔ | 98% | |||||||||||||||||
Tropicamide |
+++
M4 mAChR, IC50: 8 nM |
98% | |||||||||||||||||
Diphenmanil methylsulfate | ✔ | 98% | |||||||||||||||||
Umeclidinium bromide | ✔ | 95% | |||||||||||||||||
Otilonium bromide | ✔ | 98% | |||||||||||||||||
Flavoxate HCl |
+
mAChR, IC50: 12.2 μM |
98% | |||||||||||||||||
Ipratropium bromide | ✔ | 98% | |||||||||||||||||
Diphenidol HCl | ✔ | 98% | |||||||||||||||||
Darifenacin hydrobromide |
++++
M3 mAChR, pKi: 8.9 |
98% | |||||||||||||||||
Aclidinium Bromide |
++++
M4 mAChR, Ki: 0.21 nM M2 mAChR, Ki: 0.1 nM |
98% | |||||||||||||||||
Oxybutynin chloride | ✔ | 99% | |||||||||||||||||
Pentoxyverine citrate | ✔ | 98% | |||||||||||||||||
Solifenacin | ✔ | 98% | |||||||||||||||||
Catharanthine | ✔ | 98% | |||||||||||||||||
Benzethonium chloride |
+++
α4β2 nAChRs, IC50: 49 nM α7 nAChRs, IC50: 122 nM |
99+% | |||||||||||||||||
Vinblastine sulfate |
+
nAChR, IC50: 8.9 μM |
99% | |||||||||||||||||
PNU-120596 |
++
α7 nAChR, EC50: 216 nM |
99+% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
靶点 |
|
描述 | Rocuronium Bromide is an aminosteroid non-depolarizing neuromuscular blocker or muscle relaxant used in modern anaesthesia. Rocuronium bromide induced inflammation and pain in CPAE cells[3]. Rocuronium reduced the indirectly elicited twitch tensions in normal (IC50 = 9.84 μM) and all pretreated diaphragms in a concentration-dependent fashion[4]. Rocuronium possesses a very stable cardiovascular profile and a rapid onset of action[5]. |
[2]Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.
[5]Wicks TC. The pharmacology of rocuronium bromide (ORG 9426). AANA J. 1994 Feb;62(1):33-8.
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.64mL 0.33mL 0.16mL |
8.20mL 1.64mL 0.82mL |
16.40mL 3.28mL 1.64mL |
CAS号 | 119302-91-9 |
分子式 | C32H53BrN2O4 |
分子量 | 609.68 |
别名 | ORG 9426 Bromide;Rocuronium (bromide);(+)-Rocuronium;ORG 9426 |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,2-8°C |
溶解度 |
DMSO: 105 mg/mL(172.22 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 100 mg/mL(164.02 mM),配合低频超声助溶 |
动物实验配方 |