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首页 / 抑制剂/激动剂 / 神经信号通路 / AChE / (-)-Huperzine A

石杉碱甲 /(-)-Huperzine A {[allProObj[0].p_purity_real_show]}

货号：A161814 同义名： 石杉碱 / Hup A;(−)-Selagine

Huperzine A is a naturally occurring sesquiterpene alkaloid AChE inhibitor.

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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
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(-)-Huperzine A 化学结构 CAS号：102518-79-6
(-)-Huperzine A 化学结构
CAS号：102518-79-6
(-)-Huperzine A 3D分子结构
CAS号：102518-79-6
(-)-Huperzine A 化学结构 CAS号：102518-79-6
(-)-Huperzine A 3D分子结构 CAS号：102518-79-6
规格 价格 会员价 库存 数量
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(-)-Huperzine A 纯度/质量文件 产品仅供科研

货号：A161814 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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(-)-Huperzine A 生物活性

靶点

  • AChE

    AChE (G4 form), Ki:7 nM

  • GluR

    AChE (G4 form), Ki:7 nM
描述 Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, reversible, selective inhibitor of acetylcholinesterase (AChE) used in China for the treatment of Alzheimer's disease[3]. Inhibition of fetal bovine serum acetylcholinesterase by (-)-Huperzine A was 35-fold more potent than (+)-Huperzine A, with KI values of 6.2 nM and 210 nM, respectively. In addition, (-)-Huperzine A was 88-fold more potent in inhibiting Torpedo acetylcholinesterase than (+)-Huperzine A, with KI values of 0.25 mM and 22 mM, respectively[4]. Huperzine A treatment significantly decreased the level of intracellular Aβ42 and ameliorated oligomeric Aβ42 induced mitochondrial dysfunctions in primary cortical neurons[5].

(-)-Huperzine A 参考文献

[1]Zhang HY, Tang XC. Neuroprotective effects of huperzine A: new therapeutic targets for neurodegenerative disease. Trends Pharmacol Sci. 2006 Dec;27(12):619-25.

[2]Zhao Q, Tang XC. Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine. Eur J Pharmacol. 2002 Nov 29;455(2-3):101-7.

[3]Lei Y, Yang L, Ye CY, Qin MY, Yang HY, Jiang HL, Tang XC, Zhang HY. Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons. PLoS One. 2015 May 29;10(5):e0128366.

[4]Saxena A, Qian N, Kovach IM, Kozikowski AP, Pang YP, Vellom DC, Radić Z, Quinn D, Taylor P, Doctor BP. Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases. Protein Sci. 1994 Oct;3(10):1770-8.

[5]Lei Y, Yang L, Ye CY, Qin MY, Yang HY, Jiang HL, Tang XC, Zhang HY. Involvement of Intracellular and Mitochondrial Aβ in the Ameliorative Effects of Huperzine A against Oligomeric Aβ42-Induced Injury in Primary Rat Neurons. PLoS One. 2015 May 29;10(5):e0128366.

(-)-Huperzine A 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.13mL

0.83mL

0.41mL

20.63mL

4.13mL

2.06mL

41.27mL

8.25mL

4.13mL

(-)-Huperzine A 技术信息

CAS号102518-79-6
分子式C15H18N2O
分子量 242.316
别名 石杉碱 ;Hup A;(−)-Selagine;(-)-Selagine.;Selagine;(−)-Huperzine A;Huperzine A
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C
溶解度

DMSO: 105 mg/mL(433.32 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

30% propylene glycol+5% Tween 80+65% water 30 mg/mL suspension

Tags: (-)-Huperzine A | Hup A;(−)-Selagine;(-)-Selagine.;Selagine;(−)-Huperzine A;Huperzine A | 石杉碱 | AChE | AmBeed-信号通路专用抑制剂 | (-)-Huperzine A 纯度/质量文件 | (-)-Huperzine A 生物活性 | (-)-Huperzine A 参考文献 | (-)-Huperzine A 实验方案 | (-)-Huperzine A 技术信息

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