JNJ-7777120
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货号：A568763
JNJ-7777120 is a selective antagonist of histamine-4 receptor (H4R) with Ki of 4 ± 1 nM.
JNJ-7777120 化学结构
JNJ-7777120 3D分子结构
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JNJ-7777120 纯度/质量文件 产品仅供科研
货号：A568763
标准纯度：
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产品说明书
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JNJ-7777120 质控信息
Hydroxyzine 2HCl
99+%
Cyclizine
✔
97%
Loratadine
+
98%
Desloratadine
++
Histamine H1 receptor, IC50: 51 nM
98%
Doxylamine succinate
✔
99%
Ebastine
✔
98%
Tripelennamine HCl
+
98%
Meclizine dihydrochloride
✔
98%
Chlorpheniramine maleate
+++
Histamine H1 receptor, IC50: 12 nM
99%
Diphenhydramine HCl
✔
99%
Alcaftadine
++++
++
99%+
Fexofenadine HCl
++
Histamine H1 receptor, IC50: 246 nM
99%+
Bilastine
+++
H1 receptor, Ki: 44.15 nM
98%
Pemirolast potassium
✔
98%
Bepotastine besilate
+
Histamine H1 receptor, pIC50: 5.7
98%
Mizolastine
+++
Histamine H1 receptor, IC50: 47 nM
98%
Brompheniramine maleate
✔
98%
Carbinoxamine maleate salt
✔
99+%
Clemastine fumarate
++++
Histamine H1 receptor, IC50: 3 nM
98%
Ketotifen fumarate salt
✔
95%
Rupatadine Fumarate
++
Histamine H1 receptor, Ki: 102 nM
PAFR
98%
Famotidine
✔
97%
Roxatidine Acetate HCl
+
Histamine H2 receptor, IC50: 3.2 μM
98%
Lafutidine
✔
99%
Cimetidine
✔
98%
Nizatidine
++++
Histamine H2 receptor, IC50: 0.9 nM
AChE
98%
Ranitidine
✔
99%
Betahistine
+
Histamine H3 receptor, IC50: 1.9 μM
98%
Ciproxifan maleate
+++
Histamine H3 receptor, IC50: 9.2 nM
99%+
S 38093
++
rat H3 receptor, Ki: 1.44 μM
human H3 receptor, Ki: 1.2 μM
98%
JNJ-7777120
++++
Histamine H4 receptor, Ki: 4.5 nM
98%
Azelastine HCl
✔
98%
Epinastine HCl
✔
98%
Levodropropizine
✔
97%
Cyproheptadine hydrochloride
✔
98%
Hesperetin
✔
97%
Olopatadine HCl
✔
98%
Mianserin hydrochloride
✔
99+%
Buclizine 2HCl
✔
97%
Latrepirdine 2HCl
✔
GluR
98%
Cetirizine 2HCl
✔
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
JNJ-7777120 生物活性
靶点
描述
The histamine H4 receptor (H4R) is a completely novel fourth member of the histamine receptor family. There is a fairly selective expression of H4R on bone marrow and hematopoietic cells known to be involved in inflammatory and immune responses [3] i value of 4.5 nM [4] [5]
JNJ-7777120 参考文献
[1] Rosa AC, Pini A, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16.
[2] Jablonowski JA, Grice CA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-60.
[3] Thurmond RL. The histamine H4 receptor: from orphan to the clinic. Front Pharmacol. 2015;6:65.
[4] Jablonowski JA, Grice CA, Chai W, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003;46(19):3957-3960.
[5] Thurmond RL, Desai PJ, Dunford PJ, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004;309(1):404-413.
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JNJ-7777120 实验方案
计算器
摩尔计算器
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.60mL
0.72mL
0.36mL
18.00mL
3.60mL
1.80mL
36.00mL
7.20mL
3.60mL
JNJ-7777120 技术信息
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