Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 / 抑制剂/激动剂 /
G蛋白偶联受体/G蛋白
神经信号通路 免疫/炎症
/ 组胺受体 / JNJ-7777120

JNJ-7777120 {[allProObj[0].p_purity_real_show]}

货号：A568763 Ambeed 开学季，买赠积分，赢豪礼

JNJ-7777120 is a selective antagonist of histamine-4 receptor (H4R) with Ki of 4 ± 1 nM.

JNJ-7777120 化学结构 CAS号：459168-41-3
JNJ-7777120 化学结构
CAS号：459168-41-3
JNJ-7777120 3D分子结构
CAS号：459168-41-3
JNJ-7777120 化学结构 CAS号：459168-41-3
JNJ-7777120 3D分子结构 CAS号：459168-41-3
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

JNJ-7777120 纯度/质量文件 产品仅供科研

货号：A568763 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• JACS Au, 2024. Ambeed. [ A148168 ]
• JMC, 2024. Ambeed. [ A187643 ]
• JMC, 2024. Ambeed. [ A341145 , A633512 , A607865 , A167774 ]
• Biomacromolecules, 2024. Ambeed. [ A110759 ]
• Biomacromolecules, 2024. Ambeed. [ A203543 ]
更多 >
产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl {[allProObj[0].p_purity_real_show]}
Cyclizine ✔ {[allProObj[0].p_purity_real_show]}
Loratadine +

B(0)AT2, IC50: 4 μM

 		{[allProObj[0].p_purity_real_show]}
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		{[allProObj[0].p_purity_real_show]}
Doxylamine succinate ✔ {[allProObj[0].p_purity_real_show]}
Ebastine ✔ {[allProObj[0].p_purity_real_show]}
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		{[allProObj[0].p_purity_real_show]}
Meclizine dihydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		{[allProObj[0].p_purity_real_show]}
Diphenhydramine HCl ✔ {[allProObj[0].p_purity_real_show]}
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		{[allProObj[0].p_purity_real_show]}
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		{[allProObj[0].p_purity_real_show]}
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		{[allProObj[0].p_purity_real_show]}
Pemirolast potassium ✔ {[allProObj[0].p_purity_real_show]}
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		{[allProObj[0].p_purity_real_show]}
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		{[allProObj[0].p_purity_real_show]}
Brompheniramine maleate ✔ {[allProObj[0].p_purity_real_show]}
Carbinoxamine maleate salt ✔ {[allProObj[0].p_purity_real_show]}
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		{[allProObj[0].p_purity_real_show]}
Ketotifen fumarate salt ✔ {[allProObj[0].p_purity_real_show]}
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR {[allProObj[0].p_purity_real_show]}
Famotidine ✔ {[allProObj[0].p_purity_real_show]}
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		{[allProObj[0].p_purity_real_show]}
Lafutidine ✔ {[allProObj[0].p_purity_real_show]}
Cimetidine ✔ {[allProObj[0].p_purity_real_show]}
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE {[allProObj[0].p_purity_real_show]}
Ranitidine ✔ {[allProObj[0].p_purity_real_show]}
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		{[allProObj[0].p_purity_real_show]}
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		{[allProObj[0].p_purity_real_show]}
S 38093 ++

human H3 receptor, Ki: 1.2 μM

rat H3 receptor, Ki: 1.44 μM

 		{[allProObj[0].p_purity_real_show]}
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		{[allProObj[0].p_purity_real_show]}
Azelastine HCl ✔ {[allProObj[0].p_purity_real_show]}
Epinastine HCl ✔ {[allProObj[0].p_purity_real_show]}
Levodropropizine ✔ {[allProObj[0].p_purity_real_show]}
Cyproheptadine hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Hesperetin ✔ {[allProObj[0].p_purity_real_show]}
Olopatadine HCl ✔ {[allProObj[0].p_purity_real_show]}
Mianserin hydrochloride ✔ {[allProObj[0].p_purity_real_show]}
Buclizine 2HCl ✔ {[allProObj[0].p_purity_real_show]}
Latrepirdine 2HCl ✔ GluR {[allProObj[0].p_purity_real_show]}
Cetirizine 2HCl ✔ {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

JNJ-7777120 生物活性

靶点

  • H4 receptor

    Histamine H4 receptor, Ki:4.5 nM
描述 The histamine H4 receptor (H4R) is a completely novel fourth member of the histamine receptor family. There is a fairly selective expression of H4R on bone marrow and hematopoietic cells known to be involved in inflammatory and immune responses [3]. JNJ-7777120 is an effective and selective non-imidazole histamine H4 receptor antagonist with Ki value of 4.5 nM [4]. JNJ-7777120 has an oral bioavailability of approximately 30% in rats and 100% in dogs, with a half-life of approximately 3 h in both species. In mouse bone marrow-derived mast cells, JNJ-7777120 blocks histamine-induced chemotaxis and calcium influx. Furthermore, it can block the histamine-induced migration of tracheal mast cells from the connective tissue toward the epithelium in mice. In a mouse zymosan-induced peritonitis model which is reported to be mast cell-dependent, JNJ-7777120 significantly blocks neutrophil infiltration suggesting that its effect may be mediated by mast cells[5].

JNJ-7777120 参考文献

[1]Rosa AC, Pini A, et al. Prevention of bleomycin-induced lung inflammation and fibrosis in mice by naproxen and JNJ7777120 treatment. J Pharmacol Exp Ther. 2014 Nov;351(2):308-16.

[2]Jablonowski JA, Grice CA, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003 Sep 11;46(19):3957-60.

[3]Thurmond RL. The histamine H4 receptor: from orphan to the clinic. Front Pharmacol. 2015;6:65.

[4]Jablonowski JA, Grice CA, Chai W, et al. The first potent and selective non-imidazole human histamine H4 receptor antagonists. J Med Chem. 2003;46(19):3957-3960.

[5]Thurmond RL, Desai PJ, Dunford PJ, et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J Pharmacol Exp Ther. 2004;309(1):404-413.

JNJ-7777120 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.60mL

0.72mL

0.36mL

18.00mL

3.60mL

1.80mL

36.00mL

7.20mL

3.60mL

JNJ-7777120 技术信息

CAS号459168-41-3
分子式C14H16ClN3O
分子量 277.749
别名
运输蓝冰
存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度

DMSO: 50 mg/mL(180.02 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

30% propylene glycol+5% Tween 80+65% water 20 mg/mL suspension

Tags: JNJ-7777120 | 459168-41-3 | JNJ7777120 | JNJ 7777120 | Histamine H4R antagonist | GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Histamine Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | JNJ-7777120 纯度/质量文件 | JNJ-7777120 亚型比较 | JNJ-7777120 生物活性 | JNJ-7777120 参考文献 | JNJ-7777120 实验方案 | JNJ-7777120 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z