氢溴酸达非那新 /Darifenacin hydrobromide
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货号：A211196
同义名：
UK-88525 hydrobromide;Darifenacin (hydrobromide)
Darifenacin hydrobromide is a M3-selective antagonist with pKi of 8.9, an anticholinergic and antispasmotic agent used to treat urinary incontinence and overactive bladder syndrome.
Darifenacin hydrobromide 化学结构
Darifenacin hydrobromide 3D分子结构
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Darifenacin hydrobromide 纯度/质量文件 产品仅供科研
货号：A211196
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Darifenacin hydrobromide 质控信息
Darifenacin hydrobromide 生物活性
靶点
描述
Darifenacin hydrobromide is a selective M3 muscarinic receptor antagonist with pKi of 8.5[3] [4] [5]
Darifenacin hydrobromide 参考文献
[1] Miller DW, Hinton M, Chen F. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn. 2011 Nov;30(8):1633-8.
[2] Hegde SS, Choppin A, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol. 1997 Apr;120(8):1409-18.
[3] Hegde SS, Choppin A, Bonhaus D, Briaud S, Loeb M, Moy TM, Loury D, Eglen RM. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol. 1997 Apr;120(8):1409-18.
[4] Miller DW, Hinton M, Chen F. Evaluation of drug efflux transporter liabilities of darifenacin in cell culture models of the blood-brain and blood-ocular barriers. Neurourol Urodyn. 2011 Nov;30(8):1633-8.
[5] Iijima K, De Wachter S, Wyndaele JJ. Effects of the M3 receptor selective muscarinic antagonist darifenacin on bladder afferent activity of the rat pelvic nerve. Eur Urol. 2007 Sep;52(3):842-7.
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Darifenacin hydrobromide 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.97mL
0.39mL
0.20mL
9.85mL
1.97mL
0.99mL
19.71mL
3.94mL
1.97mL
Darifenacin hydrobromide 技术信息
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