Olopatadine HCl can block the release of histamine (IC50 = 559 µM) and stabilize mast cell.
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HazMat fee for 500 gram (Estimated)
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Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
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USD 150+
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Olopatadine hydrochloride is an antihistamine and mast cell stabilizer available as oral, intranasal and ocular preparations. It can function both as a viable alternative or addition to first line therapies such as intranasal steroids and oral antihistamines[3]. Compared to ketotifen, olopatadine provided quicker relief of symptoms, and improved symptoms of AC (Allergic conjunctivitis) and QOL (quality of life), with fewer side effects[4]. The rise in skin temperature was inhibited by pretreatment with olopatadine in a dose-dependent manner. Olopatadine also significantly inhibited increases in vascular permeability and nerve growth factor production in the skin induced by topical tacrolimus treatment. The combination application with olopatadine and tacrolimus ointment is useful for improving medication adherence with tacrolimus ointment treatment in patients with atopic dermatitis[5]. Oral administration of olopatadine inhibited passive cutaneous anaphylaxis in rats, experimental allergic rhinitis and bronchial asthmatic responses in actively sensitized guinea pigs. Olopatadine exerted no significant effects on action potential duration in isolated guinea pig myocardium and ventricular myocytes[6].
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