盐酸苯海拉明 /Diphenhydramine HCl
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货号：A884689
同义名：
Diphenhydramine (hydrochloride);DPH
Diphenhydramine HCl is a histamine H1 antagonist that is used as an antiemetic and antitussive.
Diphenhydramine HCl 化学结构
Diphenhydramine HCl 3D分子结构
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Diphenhydramine HCl 纯度/质量文件 产品仅供科研
货号：A884689
标准纯度：
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Diphenhydramine HCl 质控信息
Hydroxyzine 2HCl
99+%
Cyclizine
✔
97%
Loratadine
+
98%
Desloratadine
++
Histamine H1 receptor, IC50: 51 nM
98%
Doxylamine succinate
✔
99%
Ebastine
✔
98%
Tripelennamine HCl
+
98%
Meclizine dihydrochloride
✔
98%
Chlorpheniramine maleate
+++
Histamine H1 receptor, IC50: 12 nM
99%
Diphenhydramine HCl
✔
99%
Alcaftadine
++++
++
99%+
Fexofenadine HCl
++
Histamine H1 receptor, IC50: 246 nM
99%+
Bilastine
+++
H1 receptor, Ki: 44.15 nM
98%
Pemirolast potassium
✔
98%
Bepotastine besilate
+
Histamine H1 receptor, pIC50: 5.7
98%
Mizolastine
+++
Histamine H1 receptor, IC50: 47 nM
98%
Brompheniramine maleate
✔
98%
Carbinoxamine maleate salt
✔
99+%
Clemastine fumarate
++++
Histamine H1 receptor, IC50: 3 nM
98%
Ketotifen fumarate salt
✔
95%
Rupatadine Fumarate
++
Histamine H1 receptor, Ki: 102 nM
PAFR
98%
Famotidine
✔
97%
Roxatidine Acetate HCl
+
Histamine H2 receptor, IC50: 3.2 μM
98%
Lafutidine
✔
99%
Cimetidine
✔
98%
Nizatidine
++++
Histamine H2 receptor, IC50: 0.9 nM
AChE
98%
Ranitidine
✔
99%
Betahistine
+
Histamine H3 receptor, IC50: 1.9 μM
98%
Ciproxifan maleate
+++
Histamine H3 receptor, IC50: 9.2 nM
99%+
S 38093
++
rat H3 receptor, Ki: 1.44 μM
human H3 receptor, Ki: 1.2 μM
98%
JNJ-7777120
++++
Histamine H4 receptor, Ki: 4.5 nM
98%
Azelastine HCl
✔
98%
Epinastine HCl
✔
98%
Levodropropizine
✔
97%
Cyproheptadine hydrochloride
✔
98%
Hesperetin
✔
97%
Olopatadine HCl
✔
98%
Mianserin hydrochloride
✔
99+%
Buclizine 2HCl
✔
97%
Latrepirdine 2HCl
✔
GluR
98%
Cetirizine 2HCl
✔
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Diphenhydramine HCl 生物活性
靶点
描述
Diphenhydramine (DPH) Hydrochloride is most commonly used via oral, topical, intramuscular (IM) and intravenous (IV) routes for the palliation of pruritus, treatment of extrapyramidal symptoms, management of parkinsonism and for allergic reactions. Subcutaneous diphenhydramine injection is a safe alternative to oral and other parenteral routes, and may be particularly valuable in terminally ill patients, who are often unable to swallow and are without IV access[3] [4] [5]
Diphenhydramine HCl 参考文献
[1] Jangi SM, Asumendi A, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72.
[2] Kim YS, Shin YK, et al. Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine. Brain Res. 2000 Oct 27;881(2):190-8.
[3] Chen A, Loquias EJ, Roshan R, Levene R, Zelhof R, Hickey T, Cooney GA, Gonzalez F. Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit. Am J Hosp Palliat Care. 2017 Dec;34(10):954-957
[4] Sanchez A, Valverde A, Sinclair M, Mosley C, Singh A, Mutsaers AJ, Hanna B, Johnson R, Gu Y, Beaudoin-Kimble M. Antihistaminic and cardiorespiratory effects of diphenhydramine hydrochloride in anesthetized dogs undergoing excision of mast cell tumors. J Am Vet Med Assoc. 2017 Oct 1;251(7):804-813
[5] El Shahawy MS, El-Fayoumy M. The Influence of Adding Diphenhydramine Before Initiation of Moderate Sedation with Midazolam and Pethidine for Improving Quality of Colonoscopy. J Natl Med Assoc. 2019 Dec;111(6):648-655
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Diphenhydramine HCl 实验方案
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
3.43mL
0.69mL
0.34mL
17.13mL
3.43mL
1.71mL
34.27mL
6.85mL
3.43mL
Diphenhydramine HCl 技术信息
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