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盐酸苯海拉明 /Diphenhydramine HCl {[allProObj[0].p_purity_real_show]}

货号：A884689 同义名： Diphenhydramine (hydrochloride);DPH

Diphenhydramine HCl is a histamine H1 antagonist that is used as an antiemetic and antitussive.

Diphenhydramine HCl 化学结构 CAS号：147-24-0
Diphenhydramine HCl 化学结构
CAS号：147-24-0
Diphenhydramine HCl 3D分子结构
CAS号：147-24-0
Diphenhydramine HCl 化学结构 CAS号：147-24-0
Diphenhydramine HCl 3D分子结构 CAS号：147-24-0
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Diphenhydramine HCl 纯度/质量文件 产品仅供科研

货号：A884689 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

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更多 >
产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine ✔ 97%
Loratadine +

B(0)AT2, IC50: 4 μM

 		98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		98%
Doxylamine succinate ✔ 99%
Ebastine ✔ 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		98%
Meclizine dihydrochloride ✔ 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		99%
Diphenhydramine HCl ✔ 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		98%
Pemirolast potassium ✔ 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		98%
Brompheniramine maleate ✔ 98%
Carbinoxamine maleate salt ✔ 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		98%
Ketotifen fumarate salt ✔ 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR 98%
Famotidine ✔ 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		98%
Lafutidine ✔ 99%
Cimetidine ✔ 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE 98%
Ranitidine ✔ 98%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		98%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		99%+
S 38093 ++

rat H3 receptor, Ki: 1.44 μM

human H3 receptor, Ki: 1.2 μM

 		98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		98%
Azelastine HCl ✔ 98%
Epinastine HCl ✔ 98%
Levodropropizine ✔ 97%
Cyproheptadine hydrochloride ✔ 98%
Hesperetin ✔ 97%
Olopatadine HCl ✔ 98%
Mianserin hydrochloride ✔ 99+%
Buclizine 2HCl ✔ 97%
Latrepirdine 2HCl ✔ GluR 98%
Cetirizine 2HCl ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Diphenhydramine HCl 生物活性

靶点

  • H1 receptor
描述 Diphenhydramine (DPH) Hydrochloride is most commonly used via oral, topical, intramuscular (IM) and intravenous (IV) routes for the palliation of pruritus, treatment of extrapyramidal symptoms, management of parkinsonism and for allergic reactions. Subcutaneous diphenhydramine injection is a safe alternative to oral and other parenteral routes, and may be particularly valuable in terminally ill patients, who are often unable to swallow and are without IV access[3]. IV administration of diphenhydramine prior to MCT (mast cell tumor) excision had no clear clinical cardiorespiratory benefits over placebo in isoflurane-anesthetized dogs[4]. Intravenous diphenhydramine hydrochloride given before initiation of midazolam and pethidine offers a significant Improvement of quality of moderate sedation during colonoscopy without increasing the number of sedation related complications[5].

Diphenhydramine HCl 参考文献

[1]Jangi SM, Asumendi A, et al. Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol Res. 2004;14(7-8):363-72.

[2]Kim YS, Shin YK, et al. Block of sodium currents in rat dorsal root ganglion neurons by diphenhydramine. Brain Res. 2000 Oct 27;881(2):190-8.

[3]Chen A, Loquias EJ, Roshan R, Levene R, Zelhof R, Hickey T, Cooney GA, Gonzalez F. Safe Use of Subcutaneous Diphenhydramine in the Inpatient Hospice Unit. Am J Hosp Palliat Care. 2017 Dec;34(10):954-957

[4]Sanchez A, Valverde A, Sinclair M, Mosley C, Singh A, Mutsaers AJ, Hanna B, Johnson R, Gu Y, Beaudoin-Kimble M. Antihistaminic and cardiorespiratory effects of diphenhydramine hydrochloride in anesthetized dogs undergoing excision of mast cell tumors. J Am Vet Med Assoc. 2017 Oct 1;251(7):804-813

[5]El Shahawy MS, El-Fayoumy M. The Influence of Adding Diphenhydramine Before Initiation of Moderate Sedation with Midazolam and Pethidine for Improving Quality of Colonoscopy. J Natl Med Assoc. 2019 Dec;111(6):648-655

Diphenhydramine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.43mL

0.69mL

0.34mL

17.13mL

3.43mL

1.71mL

34.27mL

6.85mL

3.43mL

Diphenhydramine HCl 技术信息

CAS号147-24-0
分子式C17H22ClNO
分子量 291.81
别名 Diphenhydramine (hydrochloride);DPH;Difenhydramine;Diphenhydramine hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 105 mg/mL(359.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(342.68 mM)，配合低频超声助溶
动物实验配方

Tags: Diphenhydramine | 147-24-0 | Histamine Receptor Antagonist | GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Metabolic Enzyme/Protease | Anti-infection | Histamine Receptor | Endogenous Metabolite | Bacterial | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Diphenhydramine HCl 纯度/质量文件 | Diphenhydramine HCl 亚型比较 | Diphenhydramine HCl 生物活性 | Diphenhydramine HCl 参考文献 | Diphenhydramine HCl 实验方案 | Diphenhydramine HCl 技术信息

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