Levodropropizine, a common antitussive drug, suppresses seizure activity in rats with PTZ-induced (pentylenetetrazol) status epilepticus[3]. Levodropropizine is commonly used as an antitussive drug for acute and chronic cough. It is a non-opioid agent with peripheral antitussive action via the modulation of sensory neuropeptide levels in the airways[4]. Moreover, the antitussive drug has a peripheral site of action by injecting the drug intracerebroventricularly (i.c.v.). In these experiments levodropropizine (40 micrograms/50 microliters i.c.v.) did not prevent electrically-induced cough. And levodropropizine failed to prevent the vagally elicited cough in neuropeptide-depleted animals[5]. Levodropropizine (10, 50 and 200 mg/kg) reduced in a dose-dependent manner the extravasation of Evans blue dye evoked by capsaicin. Levodropropizine inhibited also substance P-evoked extravasation, whereas it did not affect the extravasation evoked by platelet activating factor. Levodropropizine (10 and 100 microM) did not affect the contraction produced by [Sar9,Met(O2)11]substance P, a selective agonist for tachykinin NK1 receptors, in the rat urinary bladder in vitro[6].
Evaluate the Efficacy and Safe... 展开 >>ty of Levotuss CR Tab. in Comparison With Levotuss Syrup in Patients With Cough Due to Acute or Chronic Bronchitis 收起 <<
Phase 3
Completed
-
Korea, Republic of
... 展开 >>
Included Seoul national hospital,10sites
Seoul, Korea, Republic of 收起 <<
Evaluate the Efficacy and Safe... 展开 >>ty of Levotuss CR Tab. in Comparison With Levotuss Syrup in Patients With Cough Due to Acute or Chronic Bronchitis 收起 <<
Phase 3
Completed
-
Korea, Republic of
... 展开 >>
Included Seoul national hospital,10sites
Seoul, Korea, Republic of 收起 <<
搜索
