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/ 组胺受体 / Epinastine HCl

Epinastine HCl {[allProObj[0].p_purity_real_show]}

货号：A303363 同义名： WAL801 hydrochloride;Epinastine (hydrochloride)

Epinastine HCl is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Epinastine HCl 化学结构 CAS号：108929-04-0
Epinastine HCl 化学结构
CAS号：108929-04-0
Epinastine HCl 3D分子结构
CAS号：108929-04-0
Epinastine HCl 化学结构 CAS号：108929-04-0
Epinastine HCl 3D分子结构 CAS号：108929-04-0
规格 价格 会员价 库存 数量
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Epinastine HCl 纯度/质量文件 产品仅供科研

货号：A303363 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 H1 receptor ↓ H2 receptor ↓ H3 receptor ↓ H4 receptor ↓ Histamine receptor ↓ 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine ✔ 97%
Loratadine +

B(0)AT2, IC50: 4 μM

 		98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

 		98%
Doxylamine succinate ✔ 99%
Ebastine ✔ 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

 		98%
Meclizine dihydrochloride ✔ 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

 		99%
Diphenhydramine HCl ✔ 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

 		++

H2 receptor, pKi: 7.2

 		99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

 		99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

 		98%
Pemirolast potassium ✔ 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

 		98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

 		98%
Brompheniramine maleate ✔ 98%
Carbinoxamine maleate salt ✔ 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

 		98%
Ketotifen fumarate salt ✔ 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

 		PAFR 98%
Famotidine ✔ 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

 		98%
Lafutidine ✔ 99%
Cimetidine ✔ 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

 		AChE 98%
Ranitidine ✔ 99%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

 		98%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

 		99%+
S 38093 ++

rat H3 receptor, Ki: 1.44 μM

human H3 receptor, Ki: 1.2 μM

 		98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

 		98%
Azelastine HCl ✔ 98%
Epinastine HCl ✔ 98%
Levodropropizine ✔ 97%
Cyproheptadine hydrochloride ✔ 98%
Hesperetin ✔ 97%
Olopatadine HCl ✔ 98%
Mianserin hydrochloride ✔ 99+%
Buclizine 2HCl ✔ 97%
Latrepirdine 2HCl ✔ GluR 98%
Cetirizine 2HCl ✔ 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Epinastine HCl 生物活性

靶点

  • Histamine receptor
描述 Epinastine hydrochloride is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis.

Epinastine HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01569191 Hypersensitivity Phase 4 Completed - United Kingdom ... 展开 >> National Pollen and Aerobiology Unit Worcester, United Kingdom, WR2 6AJ 收起 <<
NCT01569191 - Completed - -
NCT01363700 Allergic Conjunctivitis Phase 3 Completed - Japan ... 展开 >> Santen study sites Osaka, Japan 收起 <<

Epinastine HCl 参考文献

[1]Fujishima H, Ohashi Y, et al. Efficacy of epinastine hydrochloride ophthalmic solution in allergic conjunctivitis by conjunctival cedar pollen allergen challenge. Ann Allergy Asthma Immunol. 2014 Oct;113(4):476-81.

[2]Fugner A, Bechtel WD, et al. In vitro and in vivo studies of the non-sedating antihistamine epinastine. Arzneimittelforschung. 1988 Oct;38(10):1446-53.

Epinastine HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.50mL

0.70mL

0.35mL

17.50mL

3.50mL

1.75mL

34.99mL

7.00mL

3.50mL

Epinastine HCl 技术信息

CAS号108929-04-0
分子式C16H16ClN3
分子量 285.771
别名 WAL801 hydrochloride;Epinastine (hydrochloride);WAL 801CL;WAL-801CL HCl;Epinastine hydrochloride
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 50 mg/mL(174.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(349.93 mM)，配合低频超声助溶
动物实验配方

Tags: Epinastine | 108929-04-0 | WAL801 | WAL 801 | WAL-801 | Histamine H1 Receptor Antagonist | GPCR/G Protein | Neuronal Signaling | Immunology/Inflammation | Histamine Receptor | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Epinastine HCl 纯度/质量文件 | Epinastine HCl 亚型比较 | Epinastine HCl 生物活性 | Epinastine HCl 临床数据 | Epinastine HCl 参考文献 | Epinastine HCl 实验方案 | Epinastine HCl 技术信息

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