Cyproheptadine HCl | 盐酸赛庚啶半水合物 | Cyproheptadine (hydrochloride hydrate) | Histamine Receptor Antagonist

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盐酸赛庚啶半水合物 /Cyproheptadine HCl 99+%

货号：A149586 同义名： 盐酸赛庚啶半水合物 / Cyproheptadine (hydrochloride hydrate);Cyproheptadine hydrochloride sesquihydrate

Cyproheptadine Hydrochloride Sesquihydrate is a serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.

Cyproheptadine HCl 化学结构
CAS号：41354-29-4

Cyproheptadine HCl 3D分子结构
CAS号：41354-29-4

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Cyproheptadine HCl 纯度/质量文件产品仅供科研

货号：A149586 标准纯度： 99+% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024. Ambeed. [ A288696 ]; • JMC, 2024. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

5-羟色胺受体亚型比较
组胺受体亚型比较

产品名称	5-HT ↓ ↑	5-HT1 ↓ ↑	5-HT2 ↓ ↑	5-HT3 ↓ ↑	5-HT5 ↓ ↑	5-HT6 ↓ ↑	5-HT7 ↓ ↑	其他靶点	纯度
Desvenlafaxine	++ 5-HT, Ki: 40.2 nM								98%
Lamotrigine	+ 5-HT (rat brain synaptosomes), IC50: 474 μM 5-HT (human platelets), IC50: 240 μM								99%+
Venlafaxine	✔								99%+
Fluvoxamine maleate	✔								99%
Iloperidone	✔								99%+
Ziprasidone HCl	✔								98+%
Atomoxetine HCI	+ 5-HT, Ki: 77 nM								98%
Dapoxetine HCl	✔								99%+
Trazodone	✔								98+%
Clomipramine HCl	✔								99%+
Mirtazapine	✔								99+%
Escitalopram oxalate	+++ 5-HT, Ki: 0.89 nM								99%+
Duloxetine	✔								98+%
Sertraline HCl	++ 5-HT, Ki: 13 nM								99%+
Citalopram HBr	+++ serotonin reuptake, IC50: 1.8 nM								99%+
Latrepirdine 2HCl	✔							GluR	99%+
Fluoxetine hydrochloride	✔								98%
Paroxetine hydrochloride	✔							AChR	99%+
BMY 7378		++ 5-HT1D, pIC50: 5.9 5-HT1A, pIC50: 6.4	+ 5-HT2, pIC50: 5.5						97%
Flibanserin		+++ 5-HT1A, Ki: 1 nM	+ 5-HT2A, Ki: 49 nM						98%
LY310762		+ 5-HT1D, Ki: 249 nM							99%+
Cyclobenzaprine HCI			✔						99%
Blonanserin			+++ 5-HT2, Ki: 3.98 nM						99%+
Cyproheptadine HCl			++++ 5-HT2, IC50: 0.6 nM						99+%
Olanzapine			✔						99+%
Pimavanserin hemitartrate			+++ 5-HT2A, pIC50: 8.7						99%
Ketanserin			+++ 5-HT2C (Human), Ki: 2.5 nM 5-HT2C (Rat), Ki: 50 nM						99%+
Loxapine succinate			++ 5-HT2 (bovine), Ki: 6.6 nM 5-HT2 (human), Ki: 6.8 nM						99%
Agomelatine			✔						99%+
Clozapine			✔						99%+
Amitriptyline			+ 5-HT2, Ki: 235 nM					SERT	98%
PRX-08066 maleate			+++ 5-HT2B, IC50: 3.4 nM						98+%
RS-127445			++++ 5-HT2B, pKi: 9.5 5-HT2B, pIC50: 10.4						99%+
Sarpogrelate HCl			++++ 5-HT2A, Kd: 2.1 nM 5-HT2C, Kd: 1.1 nM						98%
Tropisetron				✔					99%
Palonosetron				✔					98+%
Ramosetron HCl				++++ 5-HT3 receptor, Ki: 0.091 nM					99%+
Ondansetron				✔					99%
Granisetron				✔					98%
Alosetron HCl				✔					98%
Ondansetron hydrochloride dihydrate				✔					99%+
VUF10166				++++ 5-HT3AB, Ki: 22 nM 5-HT3A, Ki: 0.04 nM					99%+
Azasetron hydrochloride				++++ 5-HT3, IC50: 0.33 nM					98%
Asenapine maleate		+++ 5-HT1B, pKi: 8.4 5-HT1A, pKi: 8.6	++++ 5-HT2A, pKi: 9.75 5-HT2C, pKi: 10.46		+++ 5-HT5A, pKi: 8.84	++++ 5-HT6, pKi: 9.6	++++ 5-HT7, pKi: 9.94		99%+
Risperidone		++ 5-HT1B, Ki: 14.9 nM 5-HT1D, Ki: 84.6 nM	++++ 5-HT2A, Ki: 61.9 nM 5-HT2C, Ki: 12 nM		+ 5-HT5A, Ki: 206 nM		++ 5-HT7, Ki: 6.6 nM		99%+
SB 271046 HCl						+++ 5-HT6, pKi: 8.92			99%+
Intepirdine						++++ 5-HT6, pKi: 9.63			99%+
SB-269970 HCl							++ 5-HT7, pKi: 8.3		98+%
BRL 15572		++ 5-HT1B, pKi: 6.1 5-HT1D, pKi: 6	++ 5-HT2A, pKi: 6.6 5-HT2B, pKi: 6.2			+ 5-HT6, pKi: 5.9	+ 5-HT7, pKi: 6.3		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	H1 receptor ↓ ↑	H2 receptor ↓ ↑	H3 receptor ↓ ↑	H4 receptor ↓ ↑	Histamine receptor ↓ ↑	其他靶点	纯度
Hydroxyzine 2HCl							99+%
Cyclizine	✔						97%
Loratadine	+ B(0)AT2, IC50: 4 μM						98%
Desloratadine	++ Histamine H1 receptor, IC50: 51 nM						99%+
Doxylamine succinate	✔						99%
Ebastine	✔						99%+
Tripelennamine HCl	+ H1 receptor, IC50: 30 μM						99%+
Meclizine dihydrochloride	✔						98%
Chlorpheniramine maleate	+++ Histamine H1 receptor, IC50: 12 nM						99%
Diphenhydramine HCl	✔						99%
Alcaftadine	++++ H1 receptor, pKi: 8.5	++ H2 receptor, pKi: 7.2					99%+
Fexofenadine HCl	++ Histamine H1 receptor, IC50: 246 nM						99%+
Bilastine	+++ H1 receptor, Ki: 44.15 nM						99%+
Pemirolast potassium	✔						99%+
Bepotastine besilate	+ Histamine H1 receptor, pIC50: 5.7						98%
Mizolastine	+++ Histamine H1 receptor, IC50: 47 nM						98%
Brompheniramine maleate	✔						99%+
Carbinoxamine maleate salt	✔						99+%
Clemastine fumarate	++++ Histamine H1 receptor, IC50: 3 nM						99%+
Ketotifen fumarate salt	✔						99%+
Rupatadine Fumarate	++ Histamine H1 receptor, Ki: 102 nM					PAFR	99%+
Famotidine		✔					99%+
Roxatidine Acetate HCl		+ Histamine H2 receptor, IC50: 3.2 μM					99%+
Lafutidine		✔					99%
Cimetidine		✔					99%+
Nizatidine		++++ Histamine H2 receptor, IC50: 0.9 nM				AChE	99%+
Ranitidine		✔					99%
Betahistine			+ Histamine H3 receptor, IC50: 1.9 μM				98%
Ciproxifan maleate			+++ Histamine H3 receptor, IC50: 9.2 nM				99%+
S 38093			++ rat H3 receptor, Ki: 1.44 μM human H3 receptor, Ki: 1.2 μM				99%+
JNJ-7777120				++++ Histamine H4 receptor, Ki: 4.5 nM			99%+
Azelastine HCl					✔		99%+
Epinastine HCl					✔		98%
Levodropropizine					✔		99%+
Cyproheptadine hydrochloride					✔		99%+
Hesperetin					✔		98%+
Olopatadine HCl					✔		99%+
Mianserin hydrochloride					✔		99+%
Buclizine 2HCl					✔		97%
Latrepirdine 2HCl					✔	GluR	99%+
Cetirizine 2HCl					✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Cyproheptadine HCl 生物活性

靶点	5-HT2 5-HT2, IC50:0.6 nM
描述	Cyproheptadine hydrochloride is an antihistamine and is an antagonist of serotonin and histamine2.

Cyproheptadine HCl 参考文献

[1]Saeed SA, Rasheed H, Gilani AU. Synergism interaction between arachidonic acid by 5-hydroxytryptamine in human platelet aggregation is mediated through multiple signalling pathways. Acta Pharmacol Sin. 2003 Oct;24(10):958-64.

[2]Honda M, Nishida T, Ono H. Tricyclic analogs cyclobenzaprine, amitriptyline and cyproheptadine inhibit the spinal reflex transmission through 5-HT(2) receptors. Eur J Pharmacol. 2003 Jan 1;458(1-2):91-9.

Cyproheptadine HCl 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.42mL

0.28mL

0.14mL

7.12mL

1.42mL

0.71mL

14.25mL

2.85mL

1.42mL

Cyproheptadine HCl 技术信息

CAS号	41354-29-4
分子式	C₄₂H₅₀Cl₂N₂O₃
分子量	701.764

别名	盐酸赛庚啶半水合物 ;Cyproheptadine (hydrochloride hydrate);Cyproheptadine hydrochloride sesquihydrate;Peritol;Periactin hydrochloride
运输	蓝冰

存储条件

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 35 mg/mL(49.87 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

盐酸赛庚啶半水合物 /Cyproheptadine HCl 99+%

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盐酸赛庚啶半水合物 /Cyproheptadine HCl 99+%

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