Chlorpheniramine Maleate is potent, less sedative antihistaminic drug, which acts by inhibiting histamine release from mast cells. Chlorpheniramine causes bronchodilation during resting period by acting on the circulating or tissue histamine in asthmatics which contributes to an increase in resting bronchomotor tone[3]. Chlorpheniramine has a serum half-life of approximately 20 hours in adults, and elimination from the body is primarily by metabolism to monodesmethyl and didesmethyl compounds. Age, dialysis, urinary pH and flow influence the elimination kinetics of chlorpheniramine[4]. A nasal gel formulation for an antihistaminic drug, Chlorpheniramine maleate (CPM), which suffers from poor oral[5]. The antihistamine chlorpheniramine maleate (CPM) is also used for symptomatic relief of hypersensitive reactions and in pruritic skin disorders[6].
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