Loratadine, a selective inverse agonist of peripheral histamine H1-receptors, is a second-generation antihistaminic drugs suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly variable oral absorption[6]. Loratadine exerted its acute and chronic toxicity especially on Ceriodaphnia dubia (LC50: 600 µg/L, EC50: 28.14 µg/L)[3]. Loratadine at 0.5 and 5 mg/kg did not significantly affect the skeletal system of young rats. At 50 mg/kg, loratadine decreased the femoral length, increased content of calcium and phosphorus in the bone mineral of the vertebra, and tended to improve mechanical properties of the tibial metaphysis[4]. Loratadine is well tolerated. At dosages of 10 mg daily, commonly reported adverse events were somnolence, fatigue and headache. Sedation occurred less frequently with loratadine than with azatadine, cetirizine, chlorpheniramine, clemastine and mequitazine[5].
United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov 收起 <<
United States, Alabama
... 展开 >>
University of Alabama
Recruiting
Birmingham, Alabama, United States, 35294
Contact: Elizabeth Harmon 205-996-9632 eharmon@uabmc.edu
Principal Investigator: Roslyn B. Mannon, MD
United States, California
University of California, Los Angeles
Recruiting
Los Angeles, California, United States, 90024
Contact: Suphamai Bunnapradist 310-794-8516 bunnapradist@mednet.ucla.edu
Principal Investigator: Janette Gadzhyan, MD, MS
University of California, San Francisco
Recruiting
San Francisco, California, United States, 94143
Contact: Emilio Fernandez 415-353-8380 Emilio.Fernandez@ucsf.edu
Principal Investigator: Flavio Vincenti, MD
United States, Connecticut
Yale University
Recruiting
New Haven, Connecticut, United States, 06511
Contact: Ricarda Tomlin 203-785-2073 ricarda.tomlin@yale.edu
Principal Investigator: Richard Formica Jr., MD
United States, Georgia
Emory University
Recruiting
Atlanta, Georgia, United States, 30322
Contact: Elizabeth Ferry 404-712-1816 elizabeth.ferry@emoryhealthcare.org
Principal Investigator: Kenneth Newell, MD, PhD
United States, Maryland
University of Maryland
Recruiting
Baltimore, Maryland, United States, 21201
Contact: Roberto Ramirez 410-328-0303 rramirez@som.umaryland.edu
Contact: Amanda Bartosic (410) 328-0303 abartosic@som.umaryland.edu
Principal Investigator: Jonathan S. Bromberg, MD, PhD
Johns Hopkins University
Not yet recruiting
Baltimore, Maryland, United States, 21287
Contact: Mullaney Marlene 410-614-6702 mmulla13@jhmi.edu
Contact: Darin Ostrander (410) 614-6702 dostran1@jhmi.edu
Principal Investigator: Daniel C. Brennan, MD
United States, Michigan
University of Michigan
Recruiting
Ann Arbor, Michigan, United States, 48109
Contact: Jennifer Mawby 734-936-4811 jlmawby@med.umich.edu
Principal Investigator: Randall Sung, MD
United States, Missouri
Washington University
Recruiting
Saint Louis, Missouri, United States, 63110
Contact: Cusanelli Rebecca 314-362-4109 rcusanel@dom.wustl.edu
Principal Investigator: Tarek Alhamad, MD
United States, New York
Icahn School of Medicine at Mount Sinai
Recruiting
New York, New York, United States, 10029
Contact: Douglas Wilson 212-659-8049 Douglas.Wilson@mountsinai.org
Principal Investigator: Madhav Menon, MD
Principal Investigator: Peter Heeger, MD
United States, Ohio
Cleveland Clinic
Recruiting
Cleveland, Ohio, United States, 44106
Contact: Dianna Sendrey 216-444-0486 sendred2@ccf.org
Principal Investigator: Emilio Poggio, MD
University Hospitals of Cleveland
Recruiting
Cleveland, Ohio, United States, 44106
Contact: Tracey Lee 216-844-5396 tracey.lee@uhhospitals.org
Principal Investigator: Donald Hricik, MD
United States, Wisconsin
University of Wisconsin
Recruiting
Madison, Wisconsin, United States, 53792
Contact: Alyssa Stucke 608-265-1257 stucke@surgery.wisc.edu
Principal Investigator: David Foley, MD
Canada, Manitoba
University of Manitoba
Recruiting
Winnipeg, Manitoba, Canada, R3A 1R9
Contact: Caroline Slivinski (204) 787-8662 cslivinski@exchange.hsc.mb.ca
Principal Investigator: Peter Nickerson, MD
Principal Investigator: David Rush, MD
Canada, Ontario
Toronto General Hospital
Recruiting
Toronto, Ontario, Canada, M5G 2C4
Contact: Franz Marie Gumabay (416) 340-4800 ext 6806 franzmarie.gumabay@uhn.ca
Principal Investigator: Kathryn Tinckam, MD 收起 <<
United States, California
... 展开 >>
Investigational Site Number 840003
Cypress, California, United States, 90630
United States, Georgia
Investigational Site Number 840006
Stockbridge, Georgia, United States, 30281
United States, Massachusetts
Investigational Site Number 840007
North Dartmouth, Massachusetts, United States, 02747
United States, Minnesota
Investigational Site Number 840010
Plymouth, Minnesota, United States, 55441
United States, Nebraska
Investigational Site Number 840001
Omaha, Nebraska, United States, 68144
United States, North Carolina
Investigational Site Number 840008
Raleigh, North Carolina, United States, 27607
United States, South Carolina
Investigational Site Number 840002
Spartanburg, South Carolina, United States, 29307
United States, Texas
Investigational Site Number 840005
San Antonio, Texas, United States, 78229 收起 <<
China, Beijing
... 展开 >> Guang'anmen Hospital, China Academy of Chinese Medical Sciences
Beijing, Beijing, China, 100053
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences
Beijing, Beijing, China, 100700
Mentougou Hospital of TCM
Beijing, Beijing, China, 102300 收起 <<
China, Beijing
... 展开 >> Peking Union Medical College Hospital traditional Chinese medicine department
Not yet recruiting
Beijing, Beijing, China, 100730
Contact: Xiaoyang Zhang, Doctor (+86)13910769068 zhangxymz@163.com 收起 <<
United States, North Carolina
... 展开 >>
Comprehensive Cancer Center of Wake Forest University
Winston-Salem, North Carolina, United States, 27157 收起 <<
Pegfilgrastim-induced Back and... 展开 >> Leg Pain 收起 <<
Phase 2
Unknown
June 2013
United States, Maine
... 展开 >>
Cancer Care of Maine
Recruiting
Brewer, Maine, United States, 04412
Contact: Thomas H Openshaw, MD 207-973-7478 topenshaw@emh.org
Principal Investigator: Thomas H Openshaw, MD
Sub-Investigator: Andrew Hertler, MD
Maine Center for Cancer Medicine
Recruiting
Scarborough, Maine, United States, 04074
Contact: Matthew Dugan, DO 207-885-7600 duganm@mccm.org
Principal Investigator: Matthew Dugan, DO
Sub-Investigator: Tracey Weisberg, MD
Sub-Investigator: Christian Thomas, MD
York Hospital
Recruiting
York, Maine, United States, 03909
Contact: Jonathan Eneman, MD 207-351-3777 jeneman@yorkhospital.com
Principal Investigator: Jonathan Eneman, MD
United States, New York
CR Wood Cancer Center
Recruiting
Glens Falls, New York, United States, 12801
Contact: Aqeel Gillani, MD 518-926-6700 aqeelgillani@hotmail.com
Principal Investigator: Aqeel Gillani, MD
United States, Vermont
Mountainview Medical Center
Recruiting
Berlin, Vermont, United States, 05602
Contact: John Valentine, MD 802-225-5400 john.valentine@cvmc.org
Principal Investigator: John Valentine, MD
Sub-Investigator: David Ospina, MD
Vermont Cancer Center
Recruiting
Burlington, Vermont, United States, 05405
Contact: Steven M Grunberg, MD 802-656-5457 steven.grunberg@uvm.edu
Contact: Karen M Wilson, MEd 802-656-4101 karen.m.wilson@uvm.edu
Principal Investigator: Steven M Grunberg, MD
Sub-Investigator: Joanna Schwartz, PharmD
Vermont Center for Cancer Medicine
Recruiting
Colchester, Vermont, United States, 05446
Contact: Dennis Sanders, MD 802-655-3400 Dennis.Sanders@vtmednet.org
Sub-Investigator: Paul Unger, MD
Sub-Investigator: Dennis Sanders, MD
Sub-Investigator: Johannes Nunnink, MD 收起 <<
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