Ambeed 大中华区 CN | ZH

中文 - ZH English - EN

Ambeed.cn

搜索

关键字搜索批量搜索

首页 收藏 购物车0
首页 /
抑制剂/激动剂
药物研究
/
药物分析
小分子阳性药 神经信号通路 其他抑制剂/激动剂
/
药物标准品
AChR 其他化合物 抗炎
/ Tropicamide

托吡卡胺 /Tropicamide {[allProObj[0].p_purity_real_show]}

货号：A130661 同义名： Ro 1-7683

Tropicamide is a mAchR M4 antagonist, used to dilate the pupil and help with examination of the eye.

Tropicamide 化学结构 CAS号：1508-75-4
Tropicamide 化学结构
CAS号：1508-75-4
Tropicamide 3D分子结构
CAS号：1508-75-4
Tropicamide 化学结构 CAS号：1508-75-4
Tropicamide 3D分子结构 CAS号：1508-75-4
规格 价格 会员价 库存 数量
{[ item.pr_size ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]}

{[ getRatePrice(item.pr_rmb, 1,1) ]}

{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} {[ suihuo_tips(item.pr_am, item.pr_size) ]} 		{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_am, item.pr_size) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} 现货 咨询 - +
购物车0 收藏 询单

Tropicamide 纯度/质量文件 产品仅供科研

货号：A130661 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Cell Host Microbe, 2024. Ambeed. [ A163338 ]
• Cancer Res., 2024. Ambeed. [ A295334 ]
• J. Pharm. Investig., 2024. Ambeed. [ A221527 , A691302 , A272538 , A187261 ]
• J. Fungi, 2024, 10(11): 751. Ambeed. [ A796919 ]
• JBC, 2024, 107935. Ambeed. [ A194396 ]
更多 >
产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

bAChE, IC50: 8.12 nM

hAChE, IC50: 11.6 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 98%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine hydrochloride ✔ 97%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 98%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		98%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Tropicamide 生物活性

靶点

  • mAChR

    M4 mAChR, IC50:8 nM
描述 Tropicamide is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist. Tropicamide causes a more rapid return of near vision and a lesser stinging sensation relative to cyclopentolate. And Tropicamide requires a shorter duration to obtain maximum cycloplegia, and rarely induces systemic side effects[3]. Moreover, the mixture containing 0.75% tropicamide and 2.5% phenylephrine was effective in pupil dilatation. It provided rapid and successful pupil dilatation for ophthalmoscopy, more than the alternate application of 1% tropicamide and 10% phenylephrine[4].

Tropicamide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02124486 Idiopathic Intracranial Hypert... 展开 >>ension 收起 << Not Applicable Active, not recruiting August 2, 2022 United Kingdom ... 展开 >> University Hospital Birmingham (Queen Elizabeth Hospital) Birmingham, West Midlands, United Kingdom, B15 2TH 收起 <<
NCT00817063 Eczema Phase 3 Completed - -
NCT00227253 - Recruiting December 2025 United States, Texas ... 展开 >> University of Texas Health Science Center at San Antonio Recruiting San Antonio, Texas, United States, 78229 Contact: Jannine D Cody, Ph.D.    210-567-9220    cody@uthscsa.edu    Contact: Daniel E Hale, M.D.    210-567-5284    hale@uthscsa.edu    Principal Investigator: Jannine D. Cody, Ph.D.          Sub-Investigator: Peter T. Fox, M.D.          Principal Investigator: Daniel E. Hale, M.D.          Sub-Investigator: Brian P Perry, M.D. 收起 <<

Tropicamide 参考文献

[1]Selk Ghaffari M, Javadzadeh R, Rajaei SM. Effects of two concentrations of topical tropicamide on the Schirmer tear test in clinically normal cats. J Feline Med Surg. 2016 Dec;18(12):965-969.

[2]Bersani FS, Imperatori C, et al. Injecting eye-drops: a mini-review on the non-clinical use of tropicamide. Hum Psychopharmacol. 2015 Jul;30(4):262-4.

[3]Yoo SG, Cho MJ, Kim US, Baek SH. Cycloplegic Refraction in Hyperopic Children: Effectiveness of a 0.5% Tropicamide and 0.5% Phenylephrine Addition to 1% Cyclopentolate Regimen. Korean J Ophthalmol. 2017 Jun;31(3):249-256. doi: 10.3341/kjo.2016.0007. Epub 2017 Apr 24. PMID: 28471102; PMCID: PMC5469928.

[4]Trinavarat A, Pituksung A. Effective pupil dilatation with a mixture of 0.75% tropicamide and 2.5% phenylephrine: A randomized controlled trial. Indian J Ophthalmol. 2009 Sep-Oct;57(5):351-4. doi: 10.4103/0301-4738.55070. PMID: 19700872; PMCID: PMC2804122.

Tropicamide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.58mL

3.52mL

1.76mL

35.17mL

7.03mL

3.52mL

Tropicamide 技术信息

CAS号1508-75-4
分子式C17H20N2O2
分子量 284.353
别名 Ro 1-7683
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,2-8°C
溶解度

DMSO: 25 mg/mL(87.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Tropicamide | 1508-75-4 | Ro 1-7683 | mAChR | mAChR M4 Antagonist | GPCR/G Protein | Neuronal Signaling | mAChR | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Tropicamide 纯度/质量文件 | Tropicamide 亚型比较 | Tropicamide 生物活性 | Tropicamide 临床数据 | Tropicamide 参考文献 | Tropicamide 实验方案 | Tropicamide 技术信息

Ambeed 相关网站 Ambeed.cn Ambeed.com
Ambeed
关于我们
联系我们
资讯中心
网站地图
产品手册
  • 批次文件查询
    • 客户支持
    技术支持
    专业术语
    缩略词释义
    质量手册
    产品咨询
    计算器
    活动政策
    订购方法
    积分商城
    活动声明
    联系我们
    400-920-2911 sales@ambeed.cn tech@ambeed.cn
    Ambeed 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质用途提供服务。

    尊敬的 Ambeed 客户您好，
    请您选择所在区域，我们将转接对应客服为您服务！

    热门区域

    A

    B

    C

    F

    G

    H

    J

    L

    N

    Q

    S

    T

    X

    Y

    Z

    热 A B C F G H J L N Q S T X Y Z