Pancuronium dibromide is a competitivenAchR antagonist, causing skeletal muscle relaxation and paralysis through competitively binding to the nicotinic receptor at the neuromuscular junction.
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Pancuronium Dibromide is a competitive AChR antagonist.Pancuronium (10 mg/kg ) reduced ACh-induced bronchoconstriction. At doses which produce 100% neuromuscular blockade, both pancuronium (0.04 mg/kg) and gallamine (4 mg/kg) potentiated vagally-induced bronchoconstriction[3].Competitive block of embryonic-type nicotinic acetylcholine receptor channels by pancuronium or atracurium after preincubation of outside-out patches with the respective blocker[4]. Moreover, Pancuronium may reduce the sodium current by interacting with the sodium channels in both the resting and open states[5].
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