Rivastigmine is a acetylcholinesterase inhibitor with IC50 value of 5.5 μM for cholinesterase, used for the treatment of mild to moderate Alzheimer's disease and Parkinson's disease.
Rivastigmine is a pseudo-irreversible, carbamate-type, brain-selective, dual AChE−BuChE inhibitor. In vitro, in male Wistar rats showed greater inhibitory potency (half maximal inhibitory concentration [IC50]) of rivastigmine toward brain BuChE and AChE compared with donepezil under optimal assay conditions (BuChE: 31 vs 7,400 nM; AChE: 4.3 vs 6.7 nM) [3]. Rivastigmine (1 mg/kg) also reduced myeloperoxidase activity and IL-6 by >60%, and the infiltration of CD11b expressing cells by 80%[4]. Rivastigmine can modify the levels of several shedding proteins and directs APP processing toward the non-amyloidogenic pathway[5].
Terminated(Stage 1 interim ana... 展开 >>lysis of efficacy met the criteria for early trial termination (futility). The trial was terminated at Stage 1; did not proceed to Stage 2.) 收起 <<
France
... 展开 >> Hôpital Privé Les Magnolias
Ballainvilliers, France, 91160
Cabinet Médical
Bergerac, France, 24100
Fleyriat Hospital
Bourg en Bresse, France, 01012
Cabinet Médical
Dijon, France, 21000
Charles Foix Hospital
Ivry sur Seine, France, 94026
Cabinet Médical
La Seyne sur Mer, France, 83500
Roger Salengro Hospital
Lille, France, 59037
Dupuytren Hospital
Limoges, France, 87042
Clinique Léopold Bellan
Magnanville, France, 78200
Cabinet Médical
Montpellier, France, 34070
Cabinet Médical 2
Montpellier, France, 34080
CHU Nantes Hôpital Laennec
Nantes, France, 44093
Cabinet Médical 2
Nice, France, 06000
Cabinet Médical
Nice, France, 06000
CHU Cochin Broca
Paris, France, 75013
Cabinet Médical
Rambouillet, France, 78120
CHU Rennes
Rennes, France, 35033
Cabinet Médical
Rodez, France, 12000
Cabinet Médical
Rueil Malmaison, France, 92500
Cabinet Médical
Saint Brieuc, France, 22000
Cabinet Médical
Toulon, France, 83000
Purpan-Casselardit Hospital - University of Toulouse
Toulouse, France, 31059 收起 <<
Terminated(Stage 1 interim ana... 展开 >>lysis of efficacy met the criteria for early trial termination (futility). The trial was terminated at Stage 1; did not proceed to Stage 2.) 收起 <<
United States, Arizona
... 展开 >>
Pivotal Research Center
Mesa, Arizona, United States, 85210
Pivotal Research Center
Peoria, Arizona, United States, 85381
United States, California
ATP Clinical Trials
Fountain Valley, California, United States, 92708
UCI Irvine Medical Center
Orange, California, United States, 92868
California Neuroscience Research Medical Group, Inc.
Sherman Oaks, California, United States, 91403
AVI Clinical Research
Torrance, California, United States, 90505
United States, Florida
Baumel-Eisner Neuromed Inst
Boca Raton, Florida, United States, 33486
Baumel-Eisner Neuromed Inst
Ft. Lauderdale, Florida, United States, 33321
Clinical Physiology Associates
Ft. Myers, Florida, United States, 33916
Baumel-Eisner Neuromed Inst
Miami Beach, Florida, United States, 33154
Stedman Clinical Trials
Tampa, Florida, United States, 33613
Johnnie B. Byrd, Sr. Alzheimer's Center & Research Inst
Tampa, Florida, United States, 33647
United States, New Jersey
Memory Enhancement Center
Long Branch, New Jersey, United States, 07740
United States, New York
Eastside Medical Research
New York, New York, United States, 10021
United States, Ohio
Neuro Center of Ohio
Toledo, Ohio, United States, 43623
United States, Oklahoma
Pahl Pharmaceutical Research, LLC
Oklahoma City, Oklahoma, United States, 73118
Clinical Pharmaceutical Trials, Inc.
Tulsa, Oklahoma, United States, 74104
United States, Pennsylvania
Clinical Trials Research Services
Pittsburgh, Pennsylvania, United States, 15206
United States, Texas
Grayline Clinical Drug Trials
Wichita Falls, Texas, United States, 76309
United States, Virginia
International Clinical Research Associates
Richmond, Virginia, United States, 23229
International Clinical Research Associates
Virginia Beach, Virginia, United States, 23452 收起 <<
United States, California
... 展开 >>
Beverly Hills, California, United States
Fresno, California, United States
United States, Florida
Boca Raton, Florida, United States
Fort Lauderdale, Florida, United States
Miami Beach, Florida, United States
United States, Massachusetts
Boston, Massachusetts, United States
United States, Oklahoma
Oklahoma City, Oklahoma, United States
Tulsa, Oklahoma, United States
United States, Texas
Wichita Falls, Texas, United States 收起 <<
Terminated(This study has been... 展开 >> terminated for administrative reasons only.) 收起 <<
-
Germany
... 展开 >>
Achim, Germany
Berlin, Germany
Leipzig, Germany
München, Germany
United Kingdom
Birmingham, United Kingdom
Bradford, United Kingdom
Crowborough, United Kingdom
Duston, United Kingdom
Oxford, United Kingdom
Sheffield, United Kingdom
St Leonards on Sea, United Kingdom
Staffordshire, United Kingdom 收起 <<
Alzheimer's Disease
... 展开 >> Central Nervous System Diseases 收起 <<
Phase 1
Completed
-
United States, California
... 展开 >>
Pacific Research Network, Inc.
San Diego, California, United States, 92103
United States, Florida
MD Clinical
Hallandale Beach, Florida, United States, 33009
United States, New Jersey
Comprehensive Clinical Research
Berlin, New Jersey, United States, 08009
Global Medical Institutes, LLC
Princeton, New Jersey, United States, 08540 收起 <<
France
... 展开 >> CHU d'Amiens Centre Mémoire Ressources Recherche
Not yet recruiting
Amiens, France, 80054
Contact: Agnès DEVENDEVILLE 03.22.66.82.40 devendeville.agnes@chu-amiens.fr
CHU d'Angers Centre Mémoire Ressources Recherche
Angers, France, 49933
CHU de Bastia Centre Mémoire Ressources Recherche
Not yet recruiting
Bastia, France, 20604
Contact: Georges RETTALI 04.95.59.18.32 georges.retali@ch-bastia.fr
CHU de Besançon Centre Mémoire Ressources Recherche
Besançon, France, 25030
CHU de Bordeaux - Service de Neurologie - Centre Mémoire Ressources Recherche -
Not yet recruiting
Bordeaux, France, 33076
Contact: Jean-François DARTIGUES 0557820116 jean-françois.dartigues@u-bordeaux.fr
CHRU Cavale Blanche Service de Gériatrie
Brest, France, 29200
Service de Neuropsychologie Hôpital Neurologique Pierre Wertheimer
Not yet recruiting
Bron, France, 69677
Contact: Hélène MOLLION 04.72.35.71.79 helene.mollion@chu-lyon.fr
CHU Côte de Nacre Service de neurologie et CMRR
Caen, France, 14033
CHU de Clermont Ferrand Centre Mémoire Ressources Recherche
Clermont-Ferrand, France, 63000
Hôpital Pasteur Service de Neurologie
Colmar, France, 68000
CHU de Dijon- CMRR
Not yet recruiting
Dijon, France, 21679
Contact: Yannick BEJOT 03.80.29.58.03 yannick.bejot@chu-dijon.fr
Chu de Grenoble CMRR, Neurologie
Not yet recruiting
Grenoble, France, 38043
Contact: Olivier MOREAUD 04 76 76 57 90 omoreaud@chu-grenoble.fr
Hôpital Roger Salengro CMRR
Lille, France, 59037
CHU Limoges Service de neurologie et CMRR
Not yet recruiting
Limoges, France, 87000
Contact: Leslie CARTZ-PIVER 05.55.43.12.15 Lcp.coglim@gmail.com
AP-HM
Marseille, France
CHU Montpellier Hôpital Gui de Chauliac CMRR
Not yet recruiting
Montpellier, France, 34295
Contact: Audrey GABOREAU DE LOUSTAL 04.67.33.60.29 a-gabelle@chu-montpellier.fr
CHU de Nantes Clinique Neurologique Hôpital GR Laennec
Not yet recruiting
Nantes, France, 44093
Contact: Claire BOUTOLEAU 02.40.16.54.22 claire.boutoleaubretonniere@chu-nantes.fr
Institut Claude Pompidou Centre Mémoire de Ressources et de Recherche
Not yet recruiting
Nice, France, 06100
Contact: Renaud David 04.92.03.47.70 claire.paquet@inserm.fr
APHP Hôpital Broca
Not yet recruiting
Paris, France, 75013
Contact: Olivier HANON 01.44.08.35.03 olivier.hanon@brc.aphp.fr
Hôpital Universitaire de la Pitié Salpêtrière Pavillon François Lhermitte
Not yet recruiting
Paris, France, 75013
Contact: Stéphane EPELBAUM 01.42.16.75.22 stephane.epelbaum@psl.aphp.fr
APHP Groupe Hospitalier Saint Louis Lariboisière Fernand Widal CMRR
Not yet recruiting
Paris, France, 75475
Contact: Claire PAQUET 01.40.05.49.54 claire.paquet@inserm.fr
CHU La Milétrie Pôle de Gériatrie
Not yet recruiting
Poitiers, France, 86021
Contact: Marc PACCALIN 05.49.44.44.27 m.paccalin@chu-poitiers.fr
CHU Reims Hôpital Maison Blanche Court Séjour Gériatrique
Not yet recruiting
Reims, France, 51092
Contact: Jean-Luc NOVELLA 03.26.78.44.10 jl.novella@chu-reims.fr
CHU de Rennes - Hôpital Pontchaillou / Service de Neurologie
Not yet recruiting
Rennes, France, 35033
Contact: Serge BELLIARD 02.99.87.30.26 serge.belliard@chu-rennes.fr
CHU de Rouen Hôpital Charles Nicolle Service Neurologie
Not yet recruiting
Rouen, France, 76031
Contact: David Wallon 06.08.97.29.59 david.wallon@chu-rouen.fr
Chu de Saint-Etienne, CMRR
Not yet recruiting
Saint-Étienne, France, 42055
Contact: Isabelle ROUCH 04.77.12.73.98 isabelle.rouch@chu-st-etienne.fr
Chu de Strasbourg Hôpital Ka Robertsau Pôle de Gériatrie - CMRR
Not yet recruiting
Strasbourg, France, 67200
Contact: Frédéric BLANC 03.88.12.86.38 frederic.blanc@chru-strasbourg.fr
Centre de Recherche Clinique du Gérontopôle Cité de la Santé
Toulouse, France
CHRU de Bretonneau Unité de gérontopsychiatrie
Not yet recruiting
Tours, France, 37000
Contact: Thomas DESMIDT 06.68.07.97.06 t.desmidt@chu-tours.fr
CHU Nancy Service de Gériatrie-CMRR
Not yet recruiting
Vandoeuvre les nancy, France, 54511
Contact: Thérèse RIVASSEAU JONVAUX 03.83.15.35.71 t.jonveaux@chu-nancy.fr
Hospice Civil de Lyon Hôpital des Charpennes
Not yet recruiting
Villeurbanne, France, 69100
Contact: Pierre KROLAK SALMON 04.72.43.20.50 pierre.krolak-salmon@chu-lyon.fr 收起 <<
Terminated(Low study accrual c... 展开 >>aused the study to be ended early.) 收起 <<
-
United States, Indiana
... 展开 >>
Touchpoint
Fishers, Indiana, United States, 46037
Methodist Center for Geriatric Medicine
Indianapolis, Indiana, United States, 46202
University Clinical Neurology
Indianapolis, Indiana, United States, 46202
Wishard Health Services
Indianapolis, Indiana, United States, 46202
St. Vincent Center for Healthy Aging
Indianapolis, Indiana, United States, 46260 收起 <<
United States, Arizona
... 展开 >>
Medici Research Centers
Peoria, Arizona, United States, 85381
United States, California
University of California, Irvine
Orange, California, United States, 92868
United States, Colorado
University of Colorado Health Sciences Center
Denver, Colorado, United States, 80220
United States, Florida
Neuromedical Research Institute (Offices in Ft. Lauderdale, Miami Beach and Boca Raton)
Ft. Lauderdale, Florida, United States, 33321
Miami Research Associates
Miami, Florida, United States, 33176
Center for Clinical Trials and Research
Venice, Florida, United States, 34285
United States, Indiana
Indiana University Alzheimer's Center
Indianapolis, Indiana, United States, 46202
United States, Missouri
St. Louis University
St. Louis, Missouri, United States, 63104
United States, New Jersey
Alzheimer's Research Corporation
Lakewood, New Jersey, United States, 08701
United States, New York
NYU Medical Center
New York, New York, United States, 10016
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Oklahoma
Pahl Brain Associates, P.C.
Oklahoma City, Oklahoma, United States, 73118
United States, Pennsylvania
Clinical Studies, Ltd., Philadelphia
Philadelphia, Pennsylvania, United States, 19106
United States, Texas
St. Paul Medical Center
Dallas, Texas, United States, 75235
United States, Washington
University of Washington, Seattle
Seattle, Washington, United States, 98108 收起 <<
Canada, Ontario
... 展开 >>
North York General Hospital
Toronto, Ontario, Canada, M2K1E1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N 3M5 收起 <<
Terminated(enrollment to slow,... 展开 >> insufficient funds) 收起 <<
-
Netherlands
... 展开 >> Academic Medical Center
Amsterdam, Netherlands, 1100 DD
University Medical Center Groningen
Groningen, Netherlands, 9700 RB
Atrium Medical Center
Heerlen, Netherlands, 6401 CX
University Medical Center St Radboud
Nijmegen, Netherlands, 6500 HB 收起 <<
Israel
... 展开 >> Novartis Investigative Site
Ashkelon, Israel
Novartis Investigational Site
Haifa, Israel
Novartis Investigative Site
Holon, Israel
Novartis Investigative Site
Ramat Gan, Israel
Novartis Investigative Site
Tel Aviv, Israel 收起 <<
Terminated(The study is premat... 展开 >>urely terminated due to a safety issue) 收起 <<
-
Netherlands
... 展开 >> Medical Center Leeuwarden
Leeuwarden, Friesland, Netherlands, 8901 BR
Gelre Hospitals; lukas site
Apeldoorn, Gelderland, Netherlands, 7300 DS
Medical Center Alkmaar
Alkmaar, Noord-Holland, Netherlands, 1800 AM
Erasmus Medical Center
Rotterdam, Zuid-Holland, Netherlands, 3000 CA
University Medical Center Utrecht
Utrecht, Netherlands, 3508 GA
Diakonessenhuis
Utrecht, Netherlands, 3582 KE 收起 <<
France
... 展开 >> Service de Neurologie et Pathologie du Mouvement Hôpital de La Timone
Recruiting
Marseille Cedex 5, France, 13385
Contact: Alexandre EUSEBIO, Dr 04.91.38.43.33 ext +33 alexandre.eusebio@ap-hm.fr 收起 <<
Korea, Republic of
... 展开 >>
Soonchunhyang University Hospital
Bucheon, Korea, Republic of, 420-767
The Catholic University of Korea Hospital
Bucheon, Korea, Republic of
Donga University Hospital
Busan, Korea, Republic of, 602-715
Changwon Fatima Hospital
Changwon, Korea, Republic of, 641-560
Keimyung University Dongsan Medical Center
Daegu, Korea, Republic of, 700-712
Daejun Eulji University Hopistal
Daejun, Korea, Republic of, 302-799
Dongguk University Medical Center
Goyang, Korea, Republic of, 41-773
Myongji Hospital
Goyang, Korea, Republic of, 412-270
Chonnam National University Hospital
Gwangju, Korea, Republic of, 501-757
Wonkwang University Hospital
Iksan, Korea, Republic of, 570-180
Inha Univeristy Hospital
Incheon, Korea, Republic of, 400-711
Gachon University Gil Medical Center
Incheon, Korea, Republic of, 405-760
Pusan National University Hospital
Pusan, Korea, Republic of, 602-739
Maryknoll Hospital
Pusan, Korea, Republic of
Bobath Memorial Hospital
Seongnam, Korea, Republic of
Kyughee University Medical Center
Seoul, Korea, Republic of, 130-702
Kangdong Sacred Heart Hospital
Seoul, Korea, Republic of, 134-701
Sungkyunkwan University, Samsung Seoul Hospital
Seoul, Korea, Republic of, 135-710
Konkuk University Hospital
Seoul, Korea, Republic of, 143-729
Hallym University Hospital
Seoul, Korea, Republic of, 150-719
Ewha Womans University Hospital
Seoul, Korea, Republic of, 158-710
Asan Medical Center
Seoul, Korea, Republic of, 431-060
Seoul Eulji Hospital
Seoul, Korea, Republic of
Seoul Medical Center
Seoul, Korea, Republic of
Seoul National University Boramae Hospital
Seoul, Korea, Republic of
Ajou University Hospital
Suwon, Korea, Republic of 收起 <<
United States, California
... 展开 >>
VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States, 92161
United States, Florida
Miami VA Healthcare System, Miami, FL
Miami, Florida, United States, 33125
James A. Haley Veterans' Hospital, Tampa, FL
Tampa, Florida, United States, 33612
United States, Illinois
Edward Hines Jr. VA Hospital, Hines, IL
Hines, Illinois, United States, 60141-5000
United States, Nebraska
Lincoln Community-Based Outpatient Clinic, Lincoln, NE
Lincoln, Nebraska, United States, 68510
United States, South Carolina
Ralph H. Johnson VA Medical Center, Charleston, SC
Charleston, South Carolina, United States, 29401-5799
United States, Texas
Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States, 77030
United States, Utah
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States, 84148 收起 <<
Korea, Republic of
... 展开 >>
Holy Family Hospital, The Catholic Univerisy of Korea, School of Medicine
Bucheon, Korea, Republic of
Busan National University Hospital
Busan, Korea, Republic of
Busan Paik Hospital, Inje University College of Medicine
Busan, Korea, Republic of
Changwon Fatima Hospital
Changwon, Korea, Republic of
Daegu Fatima Hospital
Daegu, Korea, Republic of
Keimyung University School of Medicine
Daegu, Korea, Republic of
Kyungpook National University School of Medicine
Daegu, Korea, Republic of
Myongji Hospital, Kwandong University College of Medicine
Goyang, Korea, Republic of
Dongguk University International Hospital
Ilsan, Korea, Republic of
National Health Insurance Corporation Ilsan Hospital
Ilsan, Korea, Republic of
Inha University College of Medicine
Incheon, Korea, Republic of
Gyeongsang National University College of Medicine
Jinju, Korea, Republic of
Chonnam National University, Medical School
Kwangju, Korea, Republic of
Seoul National Unviersity College of Medicine, Clinical neuroscience center, Seoul National Unviersity Bundang Hospital
Seongnam, Korea, Republic of
The Catholic Univerisy of Korea, School of Medicine
Seoul, Korea, Republic of
Pusan National University Yangsan Hospital
Yangsan, Korea, Republic of 收起 <<
United States, Maryland
... 展开 >>
Kennedy Krieger Institute
Baltimore, Maryland, United States, 21205
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710 收起 <<
Korea, Republic of
... 展开 >>
Korea University Ansan Hospital
Ansan, Gyeonggi-do, Korea, Republic of, 425-707
Myongji Hospital
Goyang-si, Gyeonggi-do, Korea, Republic of, 412-270
Wonkwang University Sanbon Medical Center
Gunpo-si, Gyeonggi-do, Korea, Republic of, 435-040
Hanyang University Guri Hospital
Guri-si, Gyeonggi-do, Korea, Republic of, 471-701
Bobath Memorial Hospital
Seongnam-si, Gyeonggi-do, Korea, Republic of, 463-480
Yong-in Hyoja Geriatric Hospital
Yongin-si, Gyeonggi-do, Korea, Republic of
Dong-A University Hospital
Busan, Korea, Republic of
Pusan National University Hospital
Busan, Korea, Republic of
Hallym University Chunchon Hospital
Chunchon, Korea, Republic of
Konyang University Hospital
Daejeon, Korea, Republic of
Inha University Hospital
Incheon, Korea, Republic of, 400-711
Jeju National University Hospital
Jeju, Korea, Republic of, 690-756
Seoul St. Mary's Hospital
Seoul, Korea, Republic of, 137-701
SungAe General Hospital
Seoul, Korea, Republic of, 150-051
Chungang University Hospital
Seoul, Korea, Republic of, 156-755
Ewha Womans University Hospital
Seoul, Korea, Republic of
Hanyang University Seoul Hospital
Seoul, Korea, Republic of
Kyung Hee University Medical Center
Seoul, Korea, Republic of
Sanggye Paik Hospital
Seoul, Korea, Republic of 收起 <<
Brazil
... 展开 >> Ferderal University of Bahia - DINEP
Salvador, Bahia, Brazil, 40.110-170
Federal University of Bahia
Salvador, Bahia, Brazil, 40110170 收起 <<
United States, New York
... 展开 >>
NYU Langone Medical Center, Department of Anesthesiology 550 First Avenue, RR-603
New York, New York, United States, 10016 收起 <<
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