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氢溴酸加兰他敏 /Galanthamine HBr {[allProObj[0].p_purity_real_show]}

货号:A523680 同义名: Galantamine hydrobromide;Galanthamine hydrobromide

Galanthamine HBr是一种天然存在的 AchE 抑制剂,IC50 值为 410 nM,是神经元 nAchRs 的变构增强剂,用于轻度至中度阿尔茨海默病的认知衰退和其他记忆障碍的治疗。

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Galanthamine HBr 化学结构 CAS号:1953-04-4
Galanthamine HBr 化学结构
CAS号:1953-04-4
Galanthamine HBr 3D分子结构
CAS号:1953-04-4
Galanthamine HBr 化学结构 CAS号:1953-04-4
Galanthamine HBr 3D分子结构 CAS号:1953-04-4
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Galanthamine HBr 纯度/质量文件 产品仅供科研

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Galanthamine HBr 生物活性

靶点
  • AChE

    AChE, IC50:0.35 μM

描述 Galanthamine Hydrobromide is acetylcholinesterase inhibitor (AChEI) and a neuroactive drug capable of passing through the blood–brain barrier and can slow down the effects of AD[3]. Incubation of the cells for 48 h with 300 nM galantamine doubled the density of α7 nicotinic receptors and tripled the expression of the antiapoptotic protein Bcl-2[4]. Moreover, pretreatment with galantamine (8 mg/kg, i.m.) prevented the reduction of EPSC (excitatory postsynaptic currents) frequency observed at 6-9 days after the soman challenge[5].

Galanthamine HBr 参考文献

[1]Pereira EF, Alkondon M, et al. Physostigmine and galanthamine: probes for a novel binding site on the alpha 4 beta 2 subtype of neuronal nicotinic acetylcholine receptors stably expressed in fibroblast cells. J Pharmacol Exp Ther. 1994 Aug;270(2):768-78.

[2]Thomsen T, Kaden B, et al. Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. Eur J Clin Chem Clin Biochem. 1991 Aug;29(8):487-92.

[3]Woo FY, Basri M, Masoumi HR, Ahmad MB, Ismail M. Formulation optimization of galantamine hydrobromide loaded gel drug reservoirs in transdermal patch for Alzheimer's disease. Int J Nanomedicine. 2015 Jun 5;10:3879-86.

[4]Arias E, Alés E, Gabilan NH, Cano-Abad MF, Villarroya M, García AG, López MG. Galantamine prevents apoptosis induced by beta-amyloid and thapsigargin: involvement of nicotinic acetylcholine receptors. Neuropharmacology. 2004 Jan;46(1):103-14.

[5]Alexandrova EA, Alkondon M, Aracava Y, Pereira EF, Albuquerque EX. Galantamine prevents long-lasting suppression of excitatory synaptic transmission in CA1 pyramidal neurons of soman-challenged guinea pigs. Neurotoxicology. 2014 Sep;44:270-8.

Galanthamine HBr 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.72mL

0.54mL

0.27mL

13.58mL

2.72mL

1.36mL

27.15mL

5.43mL

2.72mL

Galanthamine HBr 技术信息

CAS号1953-04-4
分子式C17H22BrNO3
分子量 368.27
别名 Galantamine hydrobromide;Galanthamine hydrobromide;NSC 100058;Galanthamine;Galantamine (hydrobromide)
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C

溶解方案

DMSO: 12 mg/mL(32.59 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 15 mg/mL(40.73 mM),配合低频超声,并水浴加热至45℃助溶

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
配制的工作液建议现用现配,短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
动物实验配方
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