货号:A523680 同义名: Galantamine hydrobromide;Galanthamine hydrobromide
Galanthamine HBr是一种天然存在的 AchE 抑制剂,IC50 值为 410 nM,是神经元 nAchRs 的变构增强剂,用于轻度至中度阿尔茨海默病的认知衰退和其他记忆障碍的治疗。
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
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描述 | Galanthamine Hydrobromide is acetylcholinesterase inhibitor (AChEI) and a neuroactive drug capable of passing through the blood–brain barrier and can slow down the effects of AD[3]. Incubation of the cells for 48 h with 300 nM galantamine doubled the density of α7 nicotinic receptors and tripled the expression of the antiapoptotic protein Bcl-2[4]. Moreover, pretreatment with galantamine (8 mg/kg, i.m.) prevented the reduction of EPSC (excitatory postsynaptic currents) frequency observed at 6-9 days after the soman challenge[5]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.72mL 0.54mL 0.27mL |
13.58mL 2.72mL 1.36mL |
27.15mL 5.43mL 2.72mL |
CAS号 | 1953-04-4 |
分子式 | C17H22BrNO3 |
分子量 | 368.27 |
别名 | Galantamine hydrobromide;Galanthamine hydrobromide;NSC 100058;Galanthamine;Galantamine (hydrobromide) |
运输 | 蓝冰 |
存储条件 |
In solvent -20°C:3-6个月-80°C:12个月 Pure form Inert atmosphere,Store in freezer, under -20°C |
溶解方案 |
DMSO: 12 mg/mL(32.59 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO H2O: 15 mg/mL(40.73 mM),配合低频超声,并水浴加热至45℃助溶 以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
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动物实验配方 |