奥替溴铵 /Otilonium bromide
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货号：A237499
同义名：
Octylonium bromide;SP63
Otilonium bromide is an mAchR antagonist used world-wide for the treatment of irritable bowel syndrome.
Otilonium bromide 化学结构
Otilonium bromide 3D分子结构
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Otilonium bromide 纯度/质量文件 产品仅供科研
货号：A237499
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Otilonium bromide 质控信息
Otilonium bromide 生物活性
靶点
描述
Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndrome. Otilonium bromide inhibited the generation of ACh-induced calcium signals in a dose dependent manner (IC50=880 nM)[3] + currents (INa) and Ca2+ currents (ICa), 1 mM otilonium blocked 87% IDMPP, 7% INa and 13% ICa. Otilonium inhibited the K+ -evoked catecholamine secretory response of superfused bovine chromaffin cells with an IC50 of 10 mM and inhibited the secretory responses induced by 10 s pulses of 50 mM DMPP with an IC50 of 7.4 nM[4]
Otilonium bromide 参考文献
[1] Martinez-Cutillas M, Gil V, et al. Mechanisms of action of otilonium bromide (OB) in human cultured smooth muscle cells and rat colonic strips. Neurogastroenterol Motil. 2013 Dec;25(12):e803-12.
[2] Forte E, Pizzoferrato M, et al. The use of anti-spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide. Eur Rev Med Pharmacol Sci. 2012 Jan;16(1):25-37.
[3] Lindqvist S, Hernon J, Sharp P, Johns N, Addison S, Watson M, Tighe R, Greer S, Mackay J, Rhodes M, Lewis M, Stebbings W, Speakman C, Evangelista S, Johnson I, Williams M. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol. 2002 Dec;137(7):1134-42.
[4] Gandía L, Villarroya M, Lara B, Olmos V, Gilabert JA, López MG, Martínez-Sierra R, Borges R, García AG. Otilonium: a potent blocker of neuronal nicotinic ACh receptors in bovine chromaffin cells. Br J Pharmacol. 1996 Feb;117(3):463-470.
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Otilonium bromide 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.77mL
0.35mL
0.18mL
8.87mL
1.77mL
0.89mL
17.74mL
3.55mL
1.77mL
Otilonium bromide 技术信息
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