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1-二苯甲基-4-甲基哌嗪 /Cyclizine

货号:A348582

Cyclizine是一种哌嗪类衍生物,作为组胺H1受体拮抗剂,具有抗恶心、抗呕吐作用,广泛应用于晕动病引起的恶心和呕吐的治疗中。

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Cyclizine 化学结构 CAS号:82-92-8
Cyclizine 化学结构
CAS号:82-92-8
Cyclizine 3D分子结构
CAS号:82-92-8
Cyclizine 化学结构 CAS号:82-92-8
Cyclizine 3D分子结构 CAS号:82-92-8
规格 价格 库存 数量
1mg ¥512 咨询
5mg ¥1326 咨询
10mg ¥2457 咨询
25mg ¥3969 咨询
50mg ¥4763 咨询
100mg ¥5716 咨询
购物车 收藏 询单

Cyclizine 纯度/质量文件 产品仅供科研

货号:A348582 标准纯度:
批次查询: 批次纯度:

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产品名称 H1 receptor H2 receptor H3 receptor H4 receptor Histamine receptor 其他靶点 纯度
Hydroxyzine 2HCl 99+%
Cyclizine 97%
Loratadine +

B(0)AT2, IC50: 4 μM

98%
Desloratadine ++

Histamine H1 receptor, IC50: 51 nM

98%
Doxylamine succinate 99%
Ebastine 98%
Tripelennamine HCl +

H1 receptor, IC50: 30 μM

98%
Meclizine dihydrochloride 98%
Chlorpheniramine maleate +++

Histamine H1 receptor, IC50: 12 nM

99%
Diphenhydramine HCl 99%
Alcaftadine ++++

H1 receptor, pKi: 8.5

++

H2 receptor, pKi: 7.2

99%+
Fexofenadine HCl ++

Histamine H1 receptor, IC50: 246 nM

99%+
Bilastine +++

H1 receptor, Ki: 44.15 nM

98%
Pemirolast potassium 98%
Bepotastine besilate +

Histamine H1 receptor, pIC50: 5.7

98%
Mizolastine +++

Histamine H1 receptor, IC50: 47 nM

98%
Brompheniramine maleate 98%
Carbinoxamine maleate salt 99+%
Clemastine fumarate ++++

Histamine H1 receptor, IC50: 3 nM

98%
Ketotifen fumarate salt 95%
Rupatadine Fumarate ++

Histamine H1 receptor, Ki: 102 nM

PAFR 98%
Famotidine 97%
Roxatidine Acetate HCl +

Histamine H2 receptor, IC50: 3.2 μM

98%
Lafutidine 99%
Cimetidine 98%
Nizatidine ++++

Histamine H2 receptor, IC50: 0.9 nM

AChE 98%
Ranitidine 98%
Betahistine +

Histamine H3 receptor, IC50: 1.9 μM

99%
Ciproxifan maleate +++

Histamine H3 receptor, IC50: 9.2 nM

99%+
S 38093 ++

human H3 receptor, Ki: 1.2 μM

rat H3 receptor, Ki: 1.44 μM

98%
JNJ-7777120 ++++

Histamine H4 receptor, Ki: 4.5 nM

99%
Azelastine HCl 98%
Epinastine HCl 99%
Levodropropizine 97%
Cyproheptadine hydrochloride 98%
Hesperetin 97%
Olopatadine HCl 98%
Mianserin hydrochloride 99+%
Buclizine 2HCl 97%
Latrepirdine 2HCl GluR 99%
Cetirizine 2HCl 98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

Cyclizine 生物活性

靶点
  • H1 receptor

描述 Cyclizine, a piperazine derivative, is an antihistaminic antiemetic that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness.

Cyclizine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01303809 Morbid Obesity Not Applicable Completed - New Zealand ... 展开 >> Manukau Surgery Centre Auckland, New Zealand, 2025 收起 <<
NCT02009306 Terminal Cancer Phase 4 Completed - United Kingdom ... 展开 >> Sue Ryder Leckhampton Court Hospice Cheltenham, Gloucestershire, United Kingdom, GL53 0QJ 收起 <<
NCT02288923 Arthritis Knee Not Applicable Recruiting April 30, 2018 United Kingdom ... 展开 >> Royal Devon and Exeter NHS Foundation Trust Recruiting Exeter, Devon, United Kingdom, EX2 5DW Contact: Fiona Martin, MBCHB    +441392411611 ext 2474    fiona.martin8@nhs.net    Sub-Investigator: James Cockcroft, MBCHB          Sub-Investigator: James Simpson, MBCHB 收起 <<

Cyclizine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.75mL

0.75mL

0.38mL

18.77mL

3.75mL

1.88mL

37.54mL

7.51mL

3.75mL

Cyclizine 技术信息

CAS号82-92-8
分子式C18H22N2
分子量 266.381
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,Room Temperature

溶解方案

DMSO: 105 mg/mL(394.17 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议现用现配,当天使用; 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比;如在配制过程中出现沉淀、析出现象,可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方
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