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首页 / 抑制剂/激动剂 / 神经信号通路 / AChR / Hexamethonium Bromide

六甲溴铵 /Hexamethonium Bromide {[allProObj[0].p_purity_real_show]}

货号：A139736 同义名： 溴化六甲铵 / Hexamethonium (bromide);Hexamethonium Dibromide

Hexamethonium bromide is a nicotinic cholinergic antagonist as the prototypical ganglionic blocker.

Hexamethonium Bromide 化学结构 CAS号：55-97-0
Hexamethonium Bromide 化学结构
CAS号：55-97-0
Hexamethonium Bromide 3D分子结构
CAS号：55-97-0
Hexamethonium Bromide 化学结构 CAS号：55-97-0
Hexamethonium Bromide 3D分子结构 CAS号：55-97-0
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Hexamethonium Bromide 纯度/质量文件 产品仅供科研

货号：A139736 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 AChE ↓ AChR ↓ mAChR ↓ nAChR ↓ 其他靶点 纯度
Donepezil +++

hAChE, IC50: 11.6 nM

bAChE, IC50: 8.12 nM

 		98%
Loganin ++

AChE, IC50: 3.95 μM

 		99%+
topride HCl ++

AChE, IC50: 2.04 μM

 		98%
Dehydroevodiamine HCl ✔ 99%+
Jatrorrhizine ++

AChE, IC50: 872 nM

 		99%+
Palmatine ++

AChE, IC50: 0.51 μM

 		98%
(-)-Huperzine A ++++

AChE (G4 form), Ki: 7 nM

 		98%
Galanthamine HBr ++

AChE, IC50: 0.35 μM

 		98%
Trospium chloride ✔ 99%
Tiotropium Bromide Monohydrate ✔ 98+%
Gallamine Triethiodide +

AChR, IC50: 68.0 μM

 		98%
Hexamethonium Bromide ✔ 99%
Pancuronium dibromide ✔ 98%
Neostigmine bromide ✔ 98%
Orphenadrine citrate ✔ 98%
Oxybutynin ✔ 98%
Irsogladine ✔ PDE 98%
Pyridostigmine bromide ✔ 99+%
Rivastigmine +

AChR, IC50: 5.5 μM

 		98%
Paroxetine hydrochloride ✔ 97%
Rocuronium Bromide ✔ 98%
Tropicamide +++

M4 mAChR, IC50: 8 nM

 		98%
Diphenmanil methylsulfate ✔ 98%
Umeclidinium bromide ✔ 95%
Otilonium bromide ✔ 98%
Flavoxate HCl +

mAChR, IC50: 12.2 μM

 		98%
Ipratropium bromide ✔ 98%
Diphenidol HCl ✔ 98%
Darifenacin hydrobromide ++++

M3 mAChR, pKi: 8.9

 		98%
Aclidinium Bromide ++++

M4 mAChR, Ki: 0.21 nM

M2 mAChR, Ki: 0.1 nM

 		98%
Oxybutynin chloride ✔ 99%
Pentoxyverine citrate ✔ 98%
Solifenacin ✔ 98%
Catharanthine ✔ 98%
Benzethonium chloride +++

α4β2 nAChRs, IC50: 49 nM

α7 nAChRs, IC50: 122 nM

 		99+%
Vinblastine sulfate +

nAChR, IC50: 8.9 μM

 		99%
PNU-120596 ++

α7 nAChR, EC50: 216 nM

 		99+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Hexamethonium Bromide 生物活性

靶点

  • AChR
描述 Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM[3]. At low frequencies of stimulation (0.5-2 Hz), hexamethonium (200 mM) and methyllycaconitine (2.0 mM) increased e.p.c. quantal content by 30-40%. The low frequency augmentation of e.p.c. quantal content by hexamethonium was absent when extracellular [Ca2+] was lowered from 2.0 to 0.5 mM[4].

Hexamethonium Bromide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03360136 Exhaustion; Syndrome ... 展开 >> Burnout, Professional Burnout Syndrome Adjustment Disorders 收起 << Not Applicable Recruiting July 1, 2020 Sweden ... 展开 >> PBM Sweden AB Globen Recruiting Stockholm, Södermanland, Sweden, 12177 Contact: Gunilla Brodda Jansen, Assoc. Proff.    070-716 39 13 ext +46    gunillabroddajansen@pbm.se    PBM Sweden City Recruiting Stockholm, Uppland, Sweden, 114 47 Contact: Gunilla Brodda Jansen, Assoc. Proff.    070-716 39 13 ext +46    gunillabroddajansen@pbm.se 收起 <<
NCT03468114 Enteric Infections ... 展开 >> Diarrhea 收起 << Not Applicable Recruiting December 2018 Kenya ... 展开 >> Great Lakes University Kisumu Recruiting Kisumu, Kenya Contact: Sheillah Simiyu, PhD    +254 722 215291    sheillahshie@gmail.com 收起 <<
NCT01626703 Depression Sc... 展开 >>reening Elderly 收起 << Not Applicable Completed - Korea, Republic of ... 展开 >> Chungju community health care center Chungju, Choongbuk, Korea, Republic of, 123456 收起 <<

Hexamethonium Bromide 参考文献

[1]Tian L, Prior C, et al. Hexamethonium- and methyllycaconitine-induced changes in acetylcholine release from rat motor nerve terminals. Br J Pharmacol. 1997 Nov;122(6):1025-34.

[2]Rang HP, Rylett RJ. The interaction between hexamethonium and tubocurarine on the rat neuromuscular junction. Br J Pharmacol. 1984 Mar;81(3):519-31.

[3]Rang HP, Rylett RJ. The interaction between hexamethonium and tubocurarine on the rat neuromuscular junction. Br J Pharmacol. 1984 Mar;81(3):519-31.

[4]Tian L, Prior C, Dempster J, Marshall IG. Hexamethonium- and methyllycaconitine-induced changes in acetylcholine release from rat motor nerve terminals. Br J Pharmacol. 1997 Nov;122(6):1025-34.

Hexamethonium Bromide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.76mL

0.55mL

0.28mL

13.80mL

2.76mL

1.38mL

27.61mL

5.52mL

2.76mL

Hexamethonium Bromide 技术信息

CAS号55-97-0
分子式C12H30Br2N2
分子量 362.188
别名 溴化六甲铵 ;Hexamethonium (bromide);Hexamethonium Dibromide
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 16 mg/mL(44.18 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(276.1 mM)
动物实验配方

PO 0.5% CMC-Na 100 mg/mL clear

Tags: Hexamethonium | 55-97-0 | nAChR Antagonist | Membrane Transporter/Ion Channel | Neuronal Signaling | Apoptosis | nAChR | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Hexamethonium Bromide 纯度/质量文件 | Hexamethonium Bromide 亚型比较 | Hexamethonium Bromide 生物活性 | Hexamethonium Bromide 临床数据 | Hexamethonium Bromide 参考文献 | Hexamethonium Bromide 实验方案 | Hexamethonium Bromide 技术信息

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