盐酸黄酮哌酯 /Flavoxate HCl
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货号：A666517
同义名：
Rec-7-0040;DW61
Flavoxate HCl is a competitive AChR antagonist with IC50 of 12.2 μM, used as a muscle relaxant.
Flavoxate HCl 化学结构
Flavoxate HCl 3D分子结构
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Flavoxate HCl 纯度/质量文件 产品仅供科研
货号：A666517
标准纯度：
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Flavoxate HCl 质控信息
Flavoxate HCl 生物活性
靶点
mAChR
mAChR, IC50:12.2 μM
描述
Flavoxate Hydrochloride is a muscarinic AChR antagonist. It has been reported that flavoxate causes a concentration-dependent relaxation of the tension elicited by muscarinic stimulation (IC50=35 μM) or 5 mM extracellular Ca2+ (IC50=83 μM) in rat detrusor. And flavoxate caused a concentration-dependent relaxation of human urinary bladder precontracted by K+ with much higher potency (IC50=2 μM)[3] -8 -10-5 M) inhibited cAMP formation in a concentration-dependent manner. Flavoxate (3 mg/kg, i.v.) completely abolished rhythmic bladder contractions in vehicle-pretreated rats, but not in PTX-pretreated (pertussis toxin ) rats[4]
Flavoxate HCl 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT00440739
Pain
Phase 4
Completed
-
Thailand
... 展开 >> Faculty of Medicine Siriraj Hospital, Mahidol University
Bangkok, Thailand, 10700 收起 <<
NCT00992238
Healthy
Phase 1
Completed
-
United States, North Dakota
... 展开 >>
PRACS Institute, Ltd
Fargo, North Dakota, United States, 58104 收起 <<
Flavoxate HCl 参考文献
[1] Dansette PM, Jaoen M, et al. HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp Toxicol Pathol. 2000 May;52(2):145-8.
[2] Kimura Y, Sasaki Y, et al. Mechanisms of the suppression of the bladder activity by flavoxate. Int J Urol. 1996 May;3(3):218-27.
[3] Tomoda T, Aishima M, Takano N, Nakano T, Seki N, Yonemitsu Y, Sueishi K, Naito S, Ito Y, Teramoto N. The effects of flavoxate hydrochloride on voltage-dependent L-type Ca2+ currents in human urinary bladder. Br J Pharmacol. 2005 Sep;146(1):25-32.
[4] Oka M, Kimura Y, Itoh Y, Sasaki Y, Taniguchi N, Ukai Y, Yoshikuni Y, Kimura K. Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res. 1996 Jul 15;727(1-2):91-8.
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Flavoxate HCl 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.34mL
0.47mL
0.23mL
11.68mL
2.34mL
1.17mL
23.37mL
4.67mL
2.34mL
Flavoxate HCl 技术信息
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