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/ (+)-Kavain

(+)-Kavain {[allProObj[0].p_purity_real_show]}

货号：A428642 同义名： NSC 112162;(+)-Kawain

(+)-Kavain is a positive allosteric modulator of α4β2δ subunit-containing GABAA receptors with EC50 values of 25 and 59 µM in the presence and absence of 300 µM kavain, respectively.

(+)-Kavain 化学结构 CAS号：500-64-1
(+)-Kavain 化学结构
CAS号：500-64-1
(+)-Kavain 3D分子结构
CAS号：500-64-1
(+)-Kavain 化学结构 CAS号：500-64-1
(+)-Kavain 3D分子结构 CAS号：500-64-1
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(+)-Kavain 纯度/质量文件 产品仅供科研

货号：A428642 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 GABA receptor ↓ GABAA receptor ↓ 其他靶点 纯度
Niflumic Acid ✔ 98%
Ginkgolide A ++

GABA receptor, Ki: 14.5 μM

 		98%
Valproic acid sodium ✔ Autophagy,HDAC 97%
Flumazenil ✔ 95%
Bemegride ✔ 98%
Bicuculline +++

GABAA receptor, IC50: 2 μM

 		98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 95%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.1, IC50: 50 nM

hCaV3.2, IC50: 110 nM

 		99%+
Dronedarone Hydrochloride ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ERK,p38 MAPK,ROS 99%+
Fasudil HCl ✔ PKA,Rho 98%
ML-9 ✔ MLCK,Akt 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 97%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 98%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		98%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 98%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 98%
NP118809 +

L-type calcium channel, IC50: 12.2 μM

N-type Ca2+ channel, IC50: 0.11 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 98%
Cinepazide Maleate ✔ 98%
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ p38 MAPK,Akt 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
产品名称 Sodium Channel ↓ 其他靶点 纯度
Tolperisone HCl ✔ 99%
Lamotrigine ✔ 98%
Vinpocetine ✔ 98%
Zonisamide ✔ 98%
Dronedarone Hydrochloride ✔ 95%
Procainamide hydrochloride ✔ 99%
Bupivacaine HCl ✔ 99+%
Benzocaine ✔ 98%
Carbamazepine ++

Sodium channel, IC50: 131 μM

 		98%
Ibutilide fumarate ✔ 99%+
Dibucaine HCl ✔ 99+%
Mexiletine HCl ✔ 99%
Phenytoin ✔ 99+%
Camostat Mesylate +++

epithelial sodium channel (ENaC), IC50: 50 nM

 		99%+
Levobupivacaine ✔ 97+%
Oxcarbazepine +

sodium channel, IC50: 160 μM

 		98%
Ambroxol 98+%
Primidone ✔ 99%
Propafenone ✔ 99%
A-803467 ++++

Na(V1.8) channel, IC50: 8 nM

 		99%+
Rufinamide ✔ 99%
Phenytoin sodium ✔ 98%
Proparacaine Hydrochloride +

Voltage-gated sodium channel, ED50: 3.4 mM

 		98+%
Riluzole ✔ 97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

(+)-Kavain 生物活性

描述 (+)-Kavain, a primary kavalactone derived from Piper methysticum, exhibits anticonvulsive effects by attenuating vascular smooth muscle contraction via its interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is also known to bind to the α4β2δ GABAA receptor and enhance GABA efficacy[2]. As a therapeutic agent, (+)-Kavain is utilized in treating inflammatory diseases due to its well-studied anti-inflammatory properties[4].
体外研究

At concentrations ranging from 10 to 300 μM, (+)-Kavain increases GABA-elicited responses in a concentration-dependent manner, with a moderate enhancement peaking at 170±23% at 300 μM[2].

Additionally, (+)-Kavain effectively inhibits TNF-α secretion in cells by suppressing LITAF[4].

(+)-Kavain 参考文献

[1]Bradić I, et al. [Hirschsprung's disease -- therapy and results]. Acta Chir Iugosl. 1975;22(2):183-95.

[2]Chua HC, et al. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLoS One. 2016 Jun 22;11(6):e0157700.

[3]Tang X, et al. Kavain Inhibition of LPS-Induced TNF-α via ERK/LITAF. Toxicol Res (Camb). 2016 Jan 1;5(1):188-196.

(+)-Kavain 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.34mL

0.87mL

0.43mL

21.71mL

4.34mL

2.17mL

43.43mL

8.69mL

4.34mL

(+)-Kavain 技术信息

CAS号500-64-1
分子式C14H14O3
分子量 230.259
别名 NSC 112162;(+)-Kawain;Kavain, Kawain, NSC 112162;Kavain
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,2-8°C
溶解度

DMSO: 50 mg/mL(217.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: (+)-Kavain | 500-64-1 | Membrane Transporter/Ion Channel | Neuronal Signaling | GABA Receptor | Sodium Channel | Calcium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | (+)-Kavain 纯度/质量文件 | (+)-Kavain 亚型比较 | (+)-Kavain 生物活性 | (+)-Kavain 参考文献 | (+)-Kavain 实验方案 | (+)-Kavain 技术信息

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