Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelialsodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase.
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Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
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USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Camostat mesylate (CM) is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase. It also inhibits transmembrane serine protease TMPRSS2, suggesting that it could block entry of SARS-Cov-2 (COVID-19) into lung cells in vitro[3]. In vivo, the oral administration of CM inhibited inflammation, cytokines expression and fibrosis in the pancreas. CM inhibited both MCP-1 (monocyte chemoattractant protein-1) and TNF-alpha production from monocytes, and proliferation and MCP-1 production from PSCs (panceatic stellate cells) [4]. Camostat mesilate (30 mg/kg; p.o.; twice a day for 9 days) blocks the spread and pathogenesis of SARS-CoV in a pathogenic mouse model[5]. CM alleviated the detrimental effect of LPS on cell viability and inhibited LPS-induced TNF-α and IL-6 secretions in DF-1 chicken embryo fibroblasts[6].
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