Phenytoin sodium | 5,5-Diphenylhydantoin sodium salt | Virus Protease Inhibitor

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苯妥英钠 /Phenytoin sodium {[allProObj[0].p_purity_real_show]}

货号：A228712 同义名： 5,5-Diphenylhydantoin sodium salt

Phenytoin sodium is a stabilizer of inactive voltage-gated sodium channel.

Phenytoin sodium 化学结构
CAS号：630-93-3

Phenytoin sodium 3D分子结构
CAS号：630-93-3

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Phenytoin sodium 纯度/质量文件产品仅供科研

货号：A228712 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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钠通道亚型比较

产品名称	Sodium Channel ↓ ↑	纯度
Tolperisone HCl	✔	99%
Lamotrigine	✔	98%
Vinpocetine	✔	98%
Zonisamide	✔	98%
Dronedarone Hydrochloride	✔	95%
Procainamide hydrochloride	✔	99%
Bupivacaine HCl	✔	99+%
Benzocaine	✔	98%
Carbamazepine	++ Sodium channel, IC50: 131 μM	98%
Ibutilide fumarate	✔	99%+
Dibucaine HCl	✔	99+%
Mexiletine HCl	✔	99%
Phenytoin	✔	99+%
Camostat Mesylate	+++ epithelial sodium channel (ENaC), IC50: 50 nM	99%+
Levobupivacaine	✔	97+%
Oxcarbazepine	+ sodium channel, IC50: 160 μM	98%
Ambroxol		98+%
Primidone	✔	99%
Propafenone	✔	99%
A-803467	++++ Na(V1.8) channel, IC50: 8 nM	99%+
Rufinamide	✔	99%
Phenytoin sodium	✔	98%
Proparacaine Hydrochloride	+ Voltage-gated sodium channel, ED50: 3.4 mM	98+%
Riluzole	✔	97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Phenytoin sodium 生物活性

靶点	Sodium Channel
描述	Phenytoin sodium (5,5-Diphenylhydantoin sodium salt) is a potent blocker of Voltage-gated Na+ channels (VGSCs), possessing similar antiepileptic and anti-tumor properties in mice^[1].^[2].
体内研究	Furthermore, Phenytoin sodium is used in experimental models to develop a mouse model of gingival hyperplasia. In one study, Phenytoin sodium (60 mg/kg; daily; for 28 days) significantly reduced tumor growth in six-week-old female Rag2-/- Il2rg-/- mice with MDA-MB-231 cells, demonstrating its potential in cancer research^[1].
体外研究	Phenytoin sodium is effective against partial seizures and generalized tonic-clonic seizures but not against primary generalized seizures such as absence or myoclonic seizures. Its antiepileptic effect is attributed to its voltage-dependent blocking of sodium channels^[2]. Phenytoin has low affinity for resting sodium channels at hyperpolarized membrane potentials^[3].

Phenytoin sodium 参考文献

[1]Michaela Nelson, et al. The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis. Mol Cancer. 2015 Jan 27;14(1):13.

[2]Rogawski, M.A. and W. Loscher, The neurobiology of antiepileptic drugs. Nat Rev Neurosci, 2004. 5(7): p. 553-64.

[3]Porter, R.J., et al., Mechanisms of action of antiseizure drugs. Handb Clin Neurol, 2012. 108: p. 663-81.

Phenytoin sodium 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

3.65mL

0.73mL

0.36mL

18.23mL

3.65mL

1.82mL

36.46mL

7.29mL

3.65mL

Phenytoin sodium 技术信息

CAS号	630-93-3
分子式	C₁₅H₁₁N₂NaO₂
分子量	274.25

别名	5,5-Diphenylhydantoin sodium salt
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 50 mg/mL(182.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

PO 0.5% CMC-Na 65 mg/mL suspension

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全球学术期刊中引用的产品

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Phenytoin sodium 实验方案

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