There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Niflumic acid, a drug used for joint and muscular pain, affected Ca²⁺ signaling in different models. In MG63 cells, niflumic acid induced [Ca²⁺]i rises by evoking PLC-dependent (phospholipase C) Ca²⁺ release from the endoplasmic reticulum, and Ca²⁺ entry via PKC-sensitive (protein kinase C) store-operated Ca²⁺ entry. Niflumic acid also induced Ca²⁺-independent cell death[3]. Niflumic acid (10 and 30 mM) also inhibited the noradrenaline-induced increase in perfusion pressure and 30 mM niflumic acid reduced the pressor response to 1 nmol noradrenaline by 34 +/- 6%. The increases in perfusion elicited by 5-HT (0.3 and 3 nmol) were reduced by niflumic acid (10 and 30 mM) in a concentration-dependent manner and 30 mM niflumic acid inhibited responses to 0.3 and 3 nmol 5-HT by, respectively, 49 +/- 8% and 50 +/- 7%. Niflumic acid selectively reduces a component of noradrenaline- and 5-HT-induced pressor responses by inhibiting a mechanism which leads to the opening of voltage-gated calcium channels[4]. Niflumic acid restored core and associated symptoms of peripheral neuropathy by suppressing oxidative-nitrosative stress, inflammatory cytokines (TNF-α, IL-1β) and TRPV1 level in stavudine-induced neuropathic pain in rats. Pharmacological efficacy of niflumic acid (20 mg/kg) was equivalent to pregabalin (30 mg/kg) [5].
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