贝尼地平盐酸盐 /Benidipine HCl
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货号：A214046
同义名：
盐酸贝尼地平
/ KW-3049;Benidipine (hydrochloride)
Benidipine HCl is a dihydropyridine calcium channel blocker for the treatment of hypertension.
Benidipine HCl 化学结构
Benidipine HCl 3D分子结构
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会员价
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Benidipine HCl 纯度/质量文件 产品仅供科研
货号：A214046
标准纯度：
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产品说明书
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Benidipine HCl 质控信息
CDC25B-IN-2
✔
Akt
99%+
Clevidipine
✔
97%
Verapamil HCl
✔
99%
Amlodipine
✔
99%
Amlodipine maleate
✔
98%
(+)-cis-Diltiazem HCl
✔
95%
Zegocractin
++
Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM
99%+
Tanshinone IIA sulfonate sodium
✔
98%
Ulixacaltamide
++
hCaV3.1, IC50: 50 nM
hCaV3.2, IC50: 110 nM
99%+
Dronedarone Hydrochloride
✔
95%
Nitrendipine
+
Calcium channel, IC50: 95 nM
98%
Efonidipine HCl monoethanolate
✔
98%
Cinnarizine
✔
98%
SEA0400
++
ROS,p38 MAPK,ERK
99%+
Fasudil HCl
✔
Rho,PKA
98%
ML-9
✔
MLCK,Akt
99%+
Flunarizine 2HCl
+
Calcium channel, Ki: 68 nM
95%
Lomerizine 2HCl
✔
98%
Efonidipine
✔
98%
Levamlodipine
✔
97%
Nisoldipine
++
L-type Cav1.2, IC50: 10 nM
97%
Isradipine
✔
98%
Lacidipine
✔
98%
Lercanidipine
✔
98%
Loureirin B
✔
Potassium Channel
99%+
Tetracaine HCl
✔
98%
Manidipine
+++
Calcium channel, IC50: 2.6 nM
98%
Manidipine Dihydrochlorid
+++
Calcium channel, IC50: 2.6 nM
98%
Nicardipine
✔
98%
Wilforgine
✔
98+%
Econazole
✔
99%+
Ginsenoside Rd
✔
NF-κB
98%
Fendiline HCl
✔
98+%
Mesaconitine
✔
98%
Tetrandrine
✔
95%
Nifedipine
✔
95%
Nilvadipine
++++
Calcium channel, IC50: 0.03 nM
98%
Barnidipine
++++
[3 H]nitrendipine, Ki: 0.21 nM
95+%
Azelnidipine
✔
97%
Levetiracetam
✔
98%
Nimodipine
✔
95%
Benidipine HCl
✔
98%
Pinaverium bromide
✔
98%
Pranidipine
✔
98%
NP118809
+
N-type Ca2+ channel, IC50: 0.11 μM
L-type calcium channel, IC50: 12.2 μM
98%
Amlodipine Besylate
+++
Calcium channel, IC50: 1.9 nM
97%
Cilnidipine
✔
98%
Cinepazide Maleate
✔
98%
Terfenadine
✔
98%
YM-58483
✔
99%+
Ranolazine
✔
98%
Praeruptorin A
✔
p38 MAPK,Akt
98%
Ranolazine 2HCl
✔
98%
Felodipine
++++
L-type calcium channel, IC50: 0.15 nM
98%
PD173212
+++
N-type Ca2+ channel, IC50: 36 nM
98%
Levamlodipine besylate
✔
97%
Carboxyamidotriazole Orotate
✔
98%
IGS-1.76
✔
98+%
WH-4-023
++++
++++
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Benidipine HCl 生物活性
靶点
描述
Benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV (Severe fever with thrombocytopenia syndrome virus) replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication[3] [4] [5] [6] [7]
Benidipine HCl 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT00135551
Cardiovascular Disease
Phase 4
Completed
-
Japan
... 展开 >> Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine
Ube, Yamaguchi, Japan, 755-8505 收起 <<
NCT02646397
Chronic Kidney Disease
Phase 4
Unknown
December 2017
China, Shanghai
... 展开 >>
Department of Nephrology, Shanghai Changzheng Hospital
Shanghai, Shanghai, China, 200003 收起 <<
Benidipine HCl 参考文献
[1] Choi NY, Choi H, et al. Neuroprotective effects of amlodipine besylate and benidipine hydrochloride on oxidative stress-injured neural stem cells. Brain Res. 2014 Mar 10;1551:1-12.
[2] Higo K, Karasawa A, et al. Protective effects of benidipine hydrochloride(KW-3049), a calcium antagonist, against experimental arterial calcinosis and endothelial dysfunction in rats. J Pharmacobiodyn. 1992 Mar;15(3):113-20.
[3] Li H, Zhang LK, Li SF, et al. Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality. Cell Res. 2019;29(9):739‐753
[4] Çakir T, Yücetaş ŞC, Yazici GN, Sunar M, Arslan YK, Süleyman H. Effects of Benidipine Hydrochloride on Ischemia/Reperfusion-Induced Inflammatory and Oxidative Brain İnjury in Rats [published online ahead of print, 2019 Sep 23]. Turk Neurosurg. 2019;10.5137/1019-5149.JTN.27372-19.3
[5] Suzuki O, Yoshida T, Tani S, et al. Antioxidative effects of benidipine hydrochloride in patients with hypertension independent of antihypertensive effects. Relationship between blood pressure and oxidative stress. Arzneimittelforschung. 2004;54(9):505‐512
[6] Seino H, Miyaguchi S, Yamazaki T, Ota S, Yabe R, Suzuki S. Effect of benidipine hydrochloride, a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus. Analysis after switching from cilnidipine to benidipine. Arzneimittelforschung. 2007;57(8):526‐531
[7] Sasaki H, Kanai S, Oyama T, Miyashita Y, Yamamura S, Shirai K. Effect of combination therapy of benidipine hydrochloride and candesartan cilexetil on serum lipid metabolism and blood pressure in elderly hypertensive patients with type 2 diabetes mellitus. J Atheroscler Thromb. 2006;13(3):149‐157
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Benidipine HCl 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.84mL
0.37mL
0.18mL
9.22mL
1.84mL
0.92mL
18.45mL
3.69mL
1.84mL
Benidipine HCl 技术信息
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