L-type calcium (Ca2+) channel mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Calcium channel also plays an important role in excitation-contraction coupling in the heart and is required for normal heart development and normal regulation of heart rhythm.
Nifedipine is a L-type calcium channel antagonist. In a [3H]-thymidine incorporation assay for rat vascular smooth muscle cells growth evaluation, treatment of nifedipine dose-dependently decreased the values of [3H]-thymidine incorporation to 63.82 ± 4.31%, 22.68 ± 1.22% and 5.45 ± 3.26% of those of the control, respectively, at the concentrations of 1 μM, 10 μM and 100 μM[3]. In an electrophysiology assay reported, the sustained inward current activated by 10 mM caffeine at -80 mV was completely inhibited by 1 μM nifedipine. In the absence of caffeine, nifedipine had no effect on the resting current[4].
In a balloon catheterization experiment in rats, nifedipine was administrated at a low dose of 0.3 mg/kg daily or at a high dose of 3 mg/kg daily. Treatment with nifedipine resulted in a distinct change in the size of intimal thickening in a dose-dependent fashion compared to that of the control[3]. According to another report, nifedipine also has anti-ulcer effects. In a HCI plus ethanol induced gastric mucosal injury model in rats, a single oral dose of nifedipine at the doses of 20 mg/kg or 40 mg/kg prevented the gastric mucosal injury[5]. In an acetic acid induced gastric ulcer model, nifedipine was given twice daily orally at the doses of 10 mg/kg, 20 mg/kg or 40 mg/kg for 14 consecutive days. The treatments of nifedipine dose dependently promoted the ulcer healing[5].
China, Chongqing
... 展开 >>
The First Affiliated Hospital, ChongQing medical University
Recruiting
ChongQing, Chongqing, China, 400016
Contact: Yunfeng He, Doctor 86-23-89011121
Contact: Xiaohou Wu, Doctor 86-23-89011122 收起 <<
China, Chongqing
... 展开 >>
The First Affiliated Hospital, ChongQing medical University
Recruiting
ChongQing, Chongqing, China, 400016
Contact: Yunfeng He, Doctor 86-23-89011121
Contact: Xiaohou Wu, Doctor 86-23-89011122 收起 <<
Egypt
... 展开 >> Menoufia University
Recruiting
Shebin Elkom, Egypt
Principal Investigator: tarek sayed
Saudi Arabia
Alhayah national hospital
Recruiting
Abha, Saudi Arabia
Principal Investigator: mohamed maher 收起 <<
United States, California
... 展开 >>
Memorial Care Center for Women/Long Beach Memorial Medical Center
Long Beach, California, United States, 92806 收起 <<
China, Hunan
... 展开 >> The Third Xiangya Hospital of Central South University , , China,
Recruiting
Changsha, Hunan, China, 410013
Contact: Yang Guoping , professor, doctor 0086 0731 88618326 ygp9880@126.com 收起 <<
Denmark
... 展开 >> Centre for Phsical Activity Research
Not yet recruiting
Copenhagen, Denmark, 2100
Contact: Stefan P Mortensen, DMSc smortensen@health.sdu.dk
Cardiovascular and Renal Research
Recruiting
Odense, Denmark, 5000
Contact: Stefan P Mortensen, DMSc smortensen@health.sdu.dk 收起 <<
Switzerland
... 展开 >> Department of Obstetrics, University of Zuerich
Not yet recruiting
Zuerich, Switzerland, 8091
Principal Investigator: Roland Zimmermann, Prof. Dr. med.
Principal Investigator: Ursula von Mandach, Prof. Dr. pharm. 收起 <<
Hypertension in Pregnancy
... 展开 >> Preeclampsia 收起 <<
Phase 4
Recruiting
January 2019
United States, New York
... 展开 >>
Maimonides Hospital
Recruiting
Brooklyn, New York, United States, 11219
Contact: Poroshat Shekarloo, MD pshekarloo@maimonidesmed.org
Mount Sinai West
Recruiting
New York, New York, United States, 10019
Contact: Dyese Taylor, MD 212-523-7579 dyese.taylor@mountsinai.org
Principal Investigator: Dyese Taylor, MD 收起 <<
United States, Illinois
... 展开 >>
Northwestern University Asher Center for the Study and Treatment of Depressive Disorders
Recruiting
Chicago, Illinois, United States, 60611
Contact: Minaz K Cattan, M.D. 312-695-7190 minaz.kolia@northwestern.edu
Contact: Gabrielle A Mesches, M.S. 312-695-6684 gabrielle.mesches@northwestern.edu
Principal Investigator: Katherine L Wisner, M.D., M.S. 收起 <<
United Arab Emirates
... 展开 >>
Department of obstetrics and Gynecology, Tawam Hospital
Al Ain, Abudhabi, United Arab Emirates, 15258
Tawam Hospital
Al Ain, Abudhabi, United Arab Emirates, 15258 收起 <<
Bahrain
... 展开 >>
Many Locations, Bahrain
Egypt
Many Locations, Egypt
Jordan
Many Locations, Jordan
Lebanon
Many Locations, Lebanon
Morocco
Many Locations, Morocco
Oman
Many Locations, Oman
Pakistan
Many Locations, Pakistan
Qatar
Many Locations, Qatar
Russian Federation
Many Locations, Russian Federation
Saudi Arabia
Many Locations, Saudi Arabia
United Arab Emirates
Many Locations, United Arab Emirates 收起 <<
Malaysia
... 展开 >> Obstetric and Gynaecology Department, National University of Malaysia Medical Centre
Recruiting
Cheras, Kuala Lumpur, Malaysia, 56000
Contact: national university of malaysia medical centre 60391455950
Sub-Investigator: nor zila hassan malek
Principal Investigator: nor azlin mohamed ismail 收起 <<
China, Liaoning
... 展开 >>
Chinese Medical University First Hospital
Recruiting
Shenyang, Liaoning, China
Contact: Yunpeng Liu 86024-83282802 cmu_trial@163.com 收起 <<
Israel
... 展开 >> Colposcopy Clinic, Obstetrics and Gynecology Department, Western galilee Hospital
Nahariya, Israel
Department of Obstetrics and Gynecology
Nahariya, Israel 收起 <<
China
... 展开 >> Centre for Epidemiological Studies and Clinical Trials, Ruijin Hospital Shanghai Institute of Hypertension, Shanghai Jiaotong University School of Medicine
Recruiting
Shanghai, China
Contact: Jiguang Wang, MD jiguangwang@aim.com
Greece
Hypertension Center, Third University Department of Medicine, Sotiria Hospital
Not yet recruiting
Athens, Greece
Contact: George S Stergiou, MD gstergi@med.uoa.gr
Italy
Istituto Auxologico Italiano
Recruiting
Milan, Italy
Contact: Gianfranco Parati, MD 390261911 ext 2890 gianfranco.parati@unimib.it 收起 <<
Raynaud Phenomenon Due to Trau... 展开 >>ma
Raynaud Disease
System; Sclerosis
Lupus Erythematosus, Systemic
Dermatomyositis
Ultrasound Therapy; Complications 收起 <<
Early Phase 1
Completed
-
Chile
... 展开 >> Department of Dermatology, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Santiago, RM, Chile, 7820436 收起 <<
China
... 展开 >> Division of Cardiology, Peking University First Hospital
Recruiting
Beijing, China, 100034
Contact: Yang Yu 8610-83575262 jiyou_2000@163.com
Principal Investigator: Yong Huo, MD 收起 <<
Bulgaria
... 展开 >> UMHAT "Sveti Georgi", Internal Consulting Department
Plovdiv, Bulgaria
"Multiprofile Hospital for Active Treatment - Doverie" AD, Clinic of Gastroenterology
Sofia, Bulgaria, 1632
II MHAT, Internal Clinic, Department of Gastroenterology
Sofia, Bulgaria
MC Health BG EOOD
Sofia, Bulgaria
Multiprofile Hospital for Active Treatment Lulin
Sofia, Bulgaria
MC "New rehabilitation centre'' EOOD
Stara Zagora, Bulgaria
"Multiprofile Regional Hospital for Active Treatment - Dr. St. Cherkezov" AD Department of Gastroenterology
Veliko Tarnovo, Bulgaria, 5002
Moldova, Republic of
IMSP Spitalul Clinic Municipal Nr 1
Chisinau, Moldova, Republic of
IMSP Spitalul Clinic Municipal Nr 3 "Sfanta Treime"
Chisinau, Moldova, Republic of
IMSP Spitalul Clinic Republican
Chisinau, Moldova, Republic of
Poland
Med-Gastr Centrum Medyczne
Lodz, Poland, 91-034
Ambulatorium Medyczne Medical Hair & Esthetic
Lublin, Poland, 20-844
Centrum Innowacyjnych Terapii Sp. z o.o. Oddział w Piasecznie
Piaseczno, Poland, 05-500
NZOZ Specjalistyczne Centrum Medyczne Flebo
Wolomin, Poland, 05-200
Romania
Pelican Impex SRL
Oradea, Jud. Bihor, Romania, 410469
IRGH
Cluj Napoca, Jud. Cluj, Romania, 400162
Tvm Med Serv Srl
Cluj Napoca, Jud. Cluj, Romania
Institutul Regional de Gastroenterologie si Hepatologie "Prof. Dr. Octavian Fodor"
Cluj-Napoca, Jud. Cluj, Romania, 400162
SC Schnelbach Medical Care SRL
Ploiesti, Jud. Prahova, Romania
Spit. Clinic Judetean de Urgenta "Sf. Apostol Andrei" Constanta
Constanta, Judet Constanta, Romania
Dacmed SRL
Ploiesti, Judetul Prahova, Romania
Centrul Medical de Diagnostic si Tratament Ambulator Neomed SRL
Brasov, Romania, 500283
Institutul Clinic Fundeni
Bucharest, Romania, 022328
Centrul Medical Sfanta Vineri SRL
Bucharest, Romania 收起 <<
United States, Texas
... 展开 >>
Memorial Hermann Hospital Texas Medical Center
Recruiting
Houston, Texas, United States, 77030
Contact: Jerrie S Refuerzo, M.D. 713-500-6416 Jerrie.S.Refuerzo@uth.tmc.edu
Contact: Maria Hutchinson, M.S 713-500-5850 Maria.S.Keefer@uth.tmc.edu
Principal Investigator: Jerrie S Refuerzo, M.D. 收起 <<
Israel
... 展开 >> Macabi outpatient clinic
Beer Sheba, Negev, Israel
Macabi outpatient clinic
Rehovot, Israel
Macabi HMO outpatient clinic
Tel Aviv, Israel
Asaf Harofe Hospital
Zrifin, Israel 收起 <<
United States, California
... 展开 >>
University of California, Los Angeles
Los Angeles, California, United States, 90095
University of California, Irvine
Orange, California, United States, 92868
University of California, Davis
Sacramento, California, United States, 95817
University of California, San Diego
San Diego, California, United States, 92103
University of California, San Francisco
San Francisco, California, United States, 94143 收起 <<
United States, Texas
... 展开 >>
Parkland Memorial Hospital
Recruiting
Dallas, Texas, United States, 75390
Principal Investigator: Josiah S Hawkins, MD
Sub-Investigator: Brian M Casey, MD
Sub-Investigator: Kenneth J Leveno, MD 收起 <<
Hypertension in Pregnancy
... 展开 >> Hypertension in Postpartum 收起 <<
Phase 4
Recruiting
February 11, 2019
United States, New York
... 展开 >>
Icahn School of Medicine at Mount Sinai
Recruiting
New York, New York, United States, 10029
Principal Investigator: Melissa Chu Lam, MD 收起 <<
United States, Indiana
... 展开 >>
Eskenazi Health
Indianapolis, Indiana, United States, 46202
IU Health Methodist
Indianapolis, Indiana, United States, 46202 收起 <<
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