盐酸氟桂利嗪 /Flunarizine 2HCl
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货号：A165907
同义名：
Flunarizine (hydrochloride);KW-3149
Flunarizine 2HCl is a dual Na+/Ca2+ channel (T-type) blocker with neuroprotective property.
Flunarizine 2HCl 化学结构
Flunarizine 2HCl 3D分子结构
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Flunarizine 2HCl 纯度/质量文件 产品仅供科研
货号：A165907
标准纯度：
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Flunarizine 2HCl 质控信息
CDC25B-IN-2
✔
Akt
99%+
Clevidipine
✔
97%
Verapamil HCl
✔
99%
Amlodipine
✔
99%
Amlodipine maleate
✔
98%
(+)-cis-Diltiazem HCl
✔
95%
Zegocractin
++
Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM
99%+
Tanshinone IIA sulfonate sodium
✔
98%
Ulixacaltamide
++
hCaV3.1, IC50: 50 nM
hCaV3.2, IC50: 110 nM
99%+
Dronedarone Hydrochloride
✔
95%
Nitrendipine
+
Calcium channel, IC50: 95 nM
98%
Efonidipine HCl monoethanolate
✔
98%
Cinnarizine
✔
98%
SEA0400
++
ERK,p38 MAPK,ROS
99%+
Fasudil HCl
✔
Rho,PKA
98%
ML-9
✔
MLCK,Akt
99%+
Flunarizine 2HCl
+
Calcium channel, Ki: 68 nM
95%
Lomerizine 2HCl
✔
98%
Efonidipine
✔
98%
Levamlodipine
✔
97%
Nisoldipine
++
L-type Cav1.2, IC50: 10 nM
97%
Isradipine
✔
98%
Lacidipine
✔
98%
Lercanidipine
✔
98%
Loureirin B
✔
Potassium Channel
99%+
Tetracaine HCl
✔
98%
Manidipine
+++
Calcium channel, IC50: 2.6 nM
98%
Manidipine Dihydrochlorid
+++
Calcium channel, IC50: 2.6 nM
98%
Nicardipine
✔
98%
Wilforgine
✔
98+%
Econazole
✔
99%+
Ginsenoside Rd
✔
NF-κB
98%
Fendiline HCl
✔
98+%
Mesaconitine
✔
98%
Tetrandrine
✔
95%
Nifedipine
✔
95%
Nilvadipine
++++
Calcium channel, IC50: 0.03 nM
98%
Barnidipine
++++
[3 H]nitrendipine, Ki: 0.21 nM
95+%
Azelnidipine
✔
97%
Levetiracetam
✔
98%
Nimodipine
✔
95%
Benidipine HCl
✔
98%
Pinaverium bromide
✔
98%
Pranidipine
✔
98%
NP118809
+
L-type calcium channel, IC50: 12.2 μM
N-type Ca2+ channel, IC50: 0.11 μM
98%
Amlodipine Besylate
+++
Calcium channel, IC50: 1.9 nM
97%
Cilnidipine
✔
98%
Cinepazide Maleate
✔
98%
Terfenadine
✔
98%
YM-58483
✔
99%+
Ranolazine
✔
98%
Praeruptorin A
✔
p38 MAPK,Akt
98%
Ranolazine 2HCl
✔
98%
Felodipine
++++
L-type calcium channel, IC50: 0.15 nM
98%
PD173212
+++
N-type Ca2+ channel, IC50: 36 nM
98%
Levamlodipine besylate
✔
97%
Carboxyamidotriazole Orotate
✔
98%
IGS-1.76
✔
98+%
WH-4-023
++++
++++
99%+
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Flunarizine 2HCl 生物活性
靶点
描述
Flunarizine dihydrochloride (FHC), a calcium antagonist, is used for the prophylaxis to migraine. The solubility of the poorly soluble FHC was successfully improved by preparing it as a nano emulsion[3] [4] [5] [6] [7]
Flunarizine 2HCl 临床研究
NCT号
适应症或疾病
临床期
招募状态
预计完成时间
地点
NCT03461874
Migraine Without Aura
Not Applicable
Recruiting
July 15, 2021
Italy
... 展开 >> Fondazione IRCCS Istituto Neurologico C. Besta, Neuroalgology Unit
Recruiting
Milano, Italy, 20133
Contact: Licia Grazzi, MD licia.grazzi@istituto-besta.it
Principal Investigator: Licia Grazzi, MD 收起 <<
NCT02580968
Migraine
Not Applicable
Completed
-
China
... 展开 >> Longhua Hospital,Shanghai University of Traditional Chinese Medicine
Shanghai, China, 200032 收起 <<
NCT02747940
Chronic Pain
... 展开 >> Chronic Migraine
Fibromyalgia 收起 <<
Phase 4
Recruiting
-
Taiwan
... 展开 >> Headache Center, Teipei Veterans General Hospital
Recruiting
Taipei, Taiwan, 112
Contact: Shuu-Jiun Wang, MD +886-2-28712121 ext 2425 sjwang@vghtpe.gov.tw
Contact: Jong-Ling Fuh, MD +886-2-28712121 ext 3256 jlfuh@vghtpe.gov.tw
Principal Investigator: Shuu-Jiun Wang, MD 收起 <<
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Flunarizine 2HCl 参考文献
[1] Kotake H, Kinugawa T, et al.Actions of flunarizine dihydrochloride on the electrical activity of isolated guinea-pig papillary muscle and rabbit sino-atrial node. Res Commun Chem Pathol Pharmacol. 1988 Nov;62(2):147-60.
[2] Fagbemi O, Kane KA, et al. The effects of verapamil, prenylamine, flunarizine and cinnarizine on coronary artery occlusion-induced arrhythmias in anaesthetized rats. Br J Pharmacol. 1984 Sep;83(1):299-304.
[3] Newton MJ, Harjot K. Fabrication, Characterization, In vitro Evaluation of Solid Lipid Nanoemulsion of Flunarizine dihydrochloride for Nasal Delivery. Antiinflamm Antiallergy Agents Med Chem. 2017; 15(3):204‐220
[4] Karsan N, Palethorpe D, Rattanawong W, Marin JC, Bhola R, Goadsby PJ. Flunarizine in migraine-related headache prevention: results from 200 patients treated in the UK. Eur J Neurol. 2018; 25(6):811‐817
[5] Gallop F, Fosi T, Prabhakar P, Aylett SE. Flunarizine for Headache Prophylaxis in Children With Sturge-Weber Syndrome. Pediatr Neurol. 2019; 93:27‐33
[6] Lai KL, Niddam DM, Fuh JL, et al. Flunarizine versus topiramate for chronic migraine prophylaxis: a randomized trial. Acta Neurol Scand. 2017;135(4):476‐483
[7] Jiang L, Yuan DL, Li M, et al. Combination of flunarizine and transcutaneous supraorbital neurostimulation improves migraine prophylaxis. Acta Neurol Scand. 2019;139(3):276‐283
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Flunarizine 2HCl 实验方案
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摩尔计算器
总药量计算器
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存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.09mL
0.42mL
0.21mL
10.47mL
2.09mL
1.05mL
20.95mL
4.19mL
2.09mL
Flunarizine 2HCl 技术信息
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