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/ Calcium Channel / Cinepazide Maleate

马来酸桂哌齐特 /Cinepazide Maleate {[allProObj[0].p_purity_real_show]}

货号：A469349 同义名： MD-67350

Cinepazide Maleate is a maleate salt form of cinepazide which is a vasodilator.

Cinepazide Maleate 化学结构 CAS号：26328-04-1
Cinepazide Maleate 化学结构
CAS号：26328-04-1
Cinepazide Maleate 3D分子结构
CAS号：26328-04-1
Cinepazide Maleate 化学结构 CAS号：26328-04-1
Cinepazide Maleate 3D分子结构 CAS号：26328-04-1
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Cinepazide Maleate 纯度/质量文件 产品仅供科研

货号：A469349 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 95%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.1, IC50: 50 nM

hCaV3.2, IC50: 110 nM

 		99%+
Dronedarone Hydrochloride ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ROS,ERK,p38 MAPK 99%+
Fasudil HCl ✔ Rho,PKA 98%
ML-9 ✔ Akt,MLCK 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 97%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 98%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		98%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 98%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 98%
NP118809 +

N-type Ca2+ channel, IC50: 0.11 μM

L-type calcium channel, IC50: 12.2 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 98%
Cinepazide Maleate ✔ 98%
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ Akt,p38 MAPK 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Cinepazide Maleate 生物活性

靶点

  • Calcium Channel
描述 Cinepazide Maleate (CM) is a vasodilator. Among various concentrations, 10 μM CM exhibited most significant protection on PC12 cells against OGD (oxygen-glucose deprivation) injury. CM was found to suppress OGD-induced oxidative stress, as supported by its capability of reducing intracellular reactive oxygen species and malondialdehyde production and enhancing superoxide dismutase activity. CM can protect neuronal cells against OGD injury by preserving mitochondrial functions[2]. T2D (type 2 diabetes) exacerbated CCH-induced (chronic cerebral hypoperfusion) brain damage and cognitive impairment, and CM (cinepazide maleate) ameliorated these effects[1]. Cinepazide (3 - 30 mg/kg, i.v.) produced a dose-related and transient increase in vertebral, carotid, renal and femoral arterial flow as well as cardiac output and a decrease in total peripheral resistance in anesthetized dogs. Cinepazide resembled cinnarizine and papaverine in that the drug antagonized rabbit aortic contraction induced by KCl, norepinephrine or CaCl2[3]. Cinepazide in concentrations ranging from 10(-6) to 10(-5) M augmented the relaxing responses to ATP, adenosine and cAMP. Cinepazide slightly reduced the 3H-efflux evoked by electrical stimulation. However, the relaxing response was mostly augmented by the treatment with cinepazide[4]. Cinepazide maleate combined with edaravone can effectively increase the survival rate of brain cells and promote the volatilization of neurological function in the treatment of hemorrhage in the subretinal space of the omentum[5].

Cinepazide Maleate 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01831011 Acute Ischemic Stroke Phase 2 Completed - China, Shanxi ... 展开 >> the Department of Neurology Xi an, Shanxi, China, 710032 收起 <<
NCT01851759 Ischemic Stroke Phase 2 Unknown August 2014 China, Shaanxi ... 展开 >> Xijing Hospital Not yet recruiting Xi'an, Shaanxi, China, 710032 Contact: Gang Zhao    02984775361    zhaogang@fmmu.edu.cn 收起 <<
NCT01946919 - Unknown June 2014 -

Cinepazide Maleate 参考文献

[1]Li Y, Zhang T, Zhang X, Zou W, Gong X, Fu J. Cinepazide Maleate Improves Cognitive Function and Protects Hippocampal Neurons in Diabetic Rats with Chronic Cerebral Hypoperfusion. Biol Pharm Bull. 2017;40(3):249‐255

[2]Zhao J, Bai Y, Zhang C, et al. Cinepazide maleate protects PC12 cells against oxygen-glucose deprivation-induced injury. Neurol Sci. 2014;35(6):875‐881

[3]Akashi A, Hirohashi M, Suzuki I, Shibamura S, Kasahara A. Nihon Yakurigaku Zasshi. 1979;75(5):507‐516

[4]Muramatsu I, Sakakibara Y, Hong SC, Fujiwara M. Effects of cinepazide on the purinergic responses in the dog cerebral artery. Pharmacology. 1984;28(1):27‐33

[5]Cai Z, Zhang H, Song H, Piao Y, Zhang X. Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage. Exp Ther Med. 2020;19(1):646‐650

Cinepazide Maleate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.87mL

0.37mL

0.19mL

9.37mL

1.87mL

0.94mL

18.74mL

3.75mL

1.87mL

Cinepazide Maleate 技术信息

CAS号26328-04-1
分子式C26H35N3O9
分子量 533.571
别名 MD-67350
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 105 mg/mL(196.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(93.71 mM)，配合低频超声助溶
动物实验配方

PO 0.5% CMC-Na 80 mg/mL clear

Tags: Cinepazide | 26328-04-1 | MD-67350 | MD67350 | MD 67350 | Membrane Transporter/Ion Channel | Neuronal Signaling | Calcium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Cinepazide Maleate 纯度/质量文件 | Cinepazide Maleate 亚型比较 | Cinepazide Maleate 生物活性 | Cinepazide Maleate 临床数据 | Cinepazide Maleate 参考文献 | Cinepazide Maleate 实验方案 | Cinepazide Maleate 技术信息

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