Clevidipine is a short-acting dihydropyridinecalcium channel antagonist with IC50 of 7.1 nM, it's under development for treatment of perioperative hypertension.
Clevidipine is a short-acting dihydropyridine calcium channel antagonist. Clevidipine is an ultrashort-acting drug for rapid reduction of blood pressure by selectively acting on the L-type Ca2+ channels on arteriolar smooth muscle. The drug's ultrashort action in reducing the blood pressure is due to its rapid hydrolysis by blood and extravascular tissue esterases, which does not depend on hepato-renal metabolism and excretion[3]. When myocytes were voltage-clamped with holding potential (VH) at -80 mV, 10 nM clevidipine decreased ICa at 0 mV by approximately 30%, but >50% when VH was -40 mV[4]. Clevidipine is an endothelium-independent arterial vasodilator that offers a potential therapeutic option in the treatment of perioperative arterial graft vasospasm and/or hypertension[2]. Clevidipine provided rapid BP control in patients with acute neurological injuries (including intracerebral haemorrhage, subarachnoid haemorrhage and acute ischaemic stroke), and was not associated with 'overshoot' in the vast majority of patients. Intravenous clevidipine was generally well tolerated and was usually associated with no reflex tachycardia or only very modest increases in heart rate[5]. Clevidipine administration during initial medical management of aortic dissection showed similar efficacy compared to SNP (sodium nitroprusside) when used as adjunct therapy to esmolol[6].
United States, California
... 展开 >>
University of California San Francisco
Recruiting
San Francisco, California, United States, 94122
Contact: Pekka Talke, MD 415-476-8963 pekka.talke@ucsf.edu
Contact: Pekka Talke, MD 415-476-8963 talkep@anesthesia.ucsf.edu 收起 <<
United States, California
... 展开 >>
University of California San Francisco
Recruiting
San Francisco, California, United States, 94122
Contact: Pekka Talke, MD 415-476-8963 pekka.talke@ucsf.edu
Contact: Pekka Talke, MD 415-476-8963 talkep@anesthesia.ucsf.edu 收起 <<
United States, Alabama
... 展开 >>
Jackson Hospital
Montgomery, Alabama, United States, 36106
United States, California
Centinela Hospital
Inglewood, California, United States, 90301
United States, Louisiana
Louisiana State University Health Sciences Center
Baton Rouge, Louisiana, United States, 70805
Louisiana State University Health Sciences Center - Emergency Medicine
New Orleans, Louisiana, United States, 70112
United States, Missouri
Washington University School of Medicine
St. Louis, Missouri, United States, 63110
United States, New York
Stony Brook University and Medical Center
Stony Brook, New York, United States, 11794
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Ohio
University of Cincinnati
Cincinnati, Ohio, United States, 45267
The Cleveland Clinic
Cleveland, Ohio, United States, 44195
France
Hopial AP-HP Hotel-Dieu
Paris, France, 75004
Hopital AP-HP La Pitie Sapetriere
Paris, France, 75013
Hopital AP-HP Lariboisiere Urgencies-SMUR
Paris, France, 75475
Germany
Charité - Universitätsmedizin Berlin
Berlin, Germany, 13353 收起 <<
United States, Alabama
... 展开 >>
Discovery Alliance - Mobile Infirmary Medical Center
Mobile, Alabama, United States, 36602
United States, California
Keck School of Medicine, University of Southern California
Los Angeles, California, United States, 90033
Huntington Memorial Hospital
Pasadena, California, United States, 91109
Stanford University School of Medicine
Stanford, California, United States, 94305-5640
United States, Georgia
Emory Hospital
Atlanta, Georgia, United States, 30322
United States, Illinois
Heart Care Research Foundation
Blue Island, Illinois, United States, 60406
MacNeal Hospital
Glencoe, Illinois, United States, 60022
United States, Kansas
Wesley Medical Center
Wichita, Kansas, United States, 67214
United States, Missouri
St. Lukes Hospital
Kansas City, Missouri, United States, 64111
United States, Montana
International Heart Institute
Missoula, Montana, United States, 59802
United States, New York
Mt. Sinai Medical Center
New York, New York, United States, 10029-6574
Columbia University - College of Physicians and Surgeons
New York, New York, United States, 10032
United States, North Carolina
Carolinas Medical Center
Charlotte, North Carolina, United States, 28203
United States, Texas
Discovery Alliance - Methodist Hospital / Diagnostic West Pavillion
Houston, Texas, United States, 77030
United States, Wisconsin
Medical College of Wisconsin VAMC - Milwaukee
Milwaukee, Wisconsin, United States, 53295 收起 <<
United States, Alabama
... 展开 >>
Mobile Infirmary Medical Center
Mobile, Alabama, United States, 36607
United States, Kansas
Wesley Medical Center
Wichita, Kansas, United States, 67214
United States, Louisiana
Touro Infirmary
New Orleans, Louisiana, United States, 70115
Ochsner Clinic Foundation
New Orleans, Louisiana, United States, 70121
United States, New York
Jack D. Weller Hospital
Bronx, New York, United States, 10461
Montefiore Medical Center
Bronx, New York, United States, 10467
Columbia University - College of Physicians and Surgeons
New York, New York, United States, 10032
United States, Pennsylvania
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
United States, Virginia
VA Medical Center McGuire
Richmond, Virginia, United States, 23249 收起 <<
United States, Alabama
... 展开 >>
Cardio-Thoracic Surgeons, PC
Birmingham, Alabama, United States, 35213
United States, California
St Vincent Medical Center
Los Angeles, California, United States, 90057
United States, Florida
Discovery Alliance - Hudson
Hudson, Florida, United States, 34667
Discovery Alliance - Sacred Heart Hospital
Pensacola, Florida, United States, 32503
United States, Georgia
Atlanta VA Medical Center
Atlanta, Georgia, United States, 30322
United States, Illinois
MacNeal Hospital
Berwyn, Illinois, United States, 60402
United States, North Carolina
Wake Forest University School of Medicine
Winston-Salem, North Carolina, United States, 27157
United States, Ohio
The Christ Hospital, The Linder Clinical Trial Center
Cincinnati, Ohio, United States, 45219
United States, Texas
Memorial Herman Memorial City Hospital
Houston, Texas, United States, 77024
Texas Heart Institute
Houston, Texas, United States, 77030
Houston Northwest Medical Center
Houston, Texas, United States, 77090
United States, Washington
Swedish Hospital Medical Center
Seattle, Washington, United States, 98104-1318 收起 <<
United States, Alabama
... 展开 >>
Jackson Hospital
Montgomery, Alabama, United States, 36106
United States, California
VA Medical Center W. LA
Los Angeles, California, United States, 90073
United States, District of Columbia
The George Washington University Medical Center
Washington, District of Columbia, United States, 20037
United States, Louisiana
Louisiana State University Medical Center/Charity Hospital
New Orleans, Louisiana, United States, 70118
Critical Care Research Center at Louisiana State University Health Sciences Center
Shreveport, Louisiana, United States, 71103
United States, Maryland
Good Samaritan Hospital
Baltimore, Maryland, United States, 21239
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
United States, Ohio
Metrohealth Medical Center
Cleveland, Ohio, United States, 44109
The Cleveland Clinic
Cleveland, Ohio, United States, 44195
The Toledo Hospital
Toledo, Ohio, United States, 43606
United States, Oregon
Providence Heart & Vascular Institute, d/b/a Providence St. Vincent Medical Center
Portland, Oregon, United States, 97225
United States, Pennsylvania
Hamot Shock Trauma
Erie, Pennsylvania, United States, 16550
Pennsylvania Hospital
Philadelphia, Pennsylvania, United States, 19107
United States, Texas
The University of Texas Health Science Center
Houston, Texas, United States, 77030 收起 <<
United States, Massachusetts
... 展开 >>
Massachusetts General Hospital, Harvard Medical School
Boston, Massachusetts, United States, 02114
United States, Pennsylvania
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104 收起 <<
United States, California
... 展开 >>
Stanford Medical Center
Stanford, California, United States, 94305
United States, Ohio
Nationwide Children's Hospital
Columbus, Ohio, United States, 43205 收起 <<
United States, District of Col... 展开 >>umbia
Washington Hospital Center
Washington, District of Columbia, United States, 20010-2975
United States, Hawaii
The Queens Medical Center
Honolulu, Hawaii, United States, 96813
United States, Maryland
The John Hopkins Hospital
Baltimore, Maryland, United States, 21287
United States, Massachusetts
Maine Medical Center
Portland, Massachusetts, United States, 04102
United States, Michigan
Henry Ford Hospital
Detroit, Michigan, United States, 48202
United States, New York
Columbia University Medical Center
New York, New York, United States, 10032
United States, North Carolina
Duke University Medical Center
Durham, North Carolina, United States, 27710
Guilford Neurologic - Moses H Cone Health System
Greensboro, North Carolina, United States, 27405
United States, Ohio
Cleveland Clinic Hospitals
Cleveland, Ohio, United States, 44195
The Ohio State University
Columbus, Ohio, United States, 43210
United States, Pennsylvania
Thomas Jefferson University Stroke Research
Philadelphia, Pennsylvania, United States, 19107
United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
United States, Texas
The University Health Science Center at S.A.
San Antonio, Texas, United States, 78229-3900
United States, Utah
Intermountain Medical Center
Murray, Utah, United States, 84157
Germany
Universitätsklinikum Leipzig
Liebigstraße 22a, Leipzig, Germany, D-04103
Universitatsklinikum Erlangen
Erlangen, Germany, D91054
Universitatsklinikum Heidelberg
Heidelberg, Germany, D69120 收起 <<
United States, Michigan
... 展开 >>
Henry Ford hospital
Not yet recruiting
Detroit, Michigan, United States, 48202
Principal Investigator: Panayiotis Varelas, MD, PhD 收起 <<
搜索
