Ranolazine is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP)[3]. Ranolazine antagonizes the ventricular repolarization changes caused by clofilium and suppresses clofilium-induced TdP (Torsade de Pointes) in rabbits[4]. Ranolazine potentiates the effects of ACEIs (angiotensin-converting enzyme inhibitor) and ARBs (angiotensin receptor blocker). Clinicians should monitor for this potentiation when initiating treatment with ranolazine and an ACEI or ARB[5]. Ranolazine is also a partial fatty acid oxidation (FAO) inhibitor. Ranolazine reduces cellular acetyl-CoA content via inhibition of fatty acid beta-oxidation and activates pyruvate dehydrogenase. Ranolazine significantly reduces infarct size and cardiac troponin T release in rats subjected to left anterior descending coronary artery occlusion-reperfusion[6]. Ranolazine therapy may decrease A1C (andhemoglobin A1C) among patients with T2DM without an increase in hypoglycemia. For patients with T2DM (type 2 diabetes mellitus) and chronic stable angina, ranolazine may be of use given its utility in cardiovascular disease and benefit in A1C lowering[7].
United States, Florida
... 展开 >>
Novartis Investigative Site
Jacksonville, Florida, United States, 32216
United States, New York
Novartis Investigative Site
New York, New York, United States, 10021 收起 <<
United States, California
... 展开 >>
Profil Institute for Clinical Research, Inc.
Chula Vista, California, United States, 91911
United States, Florida
SeaView Research, Inc
Miami, Florida, United States, 33126
Translational Research Institute-Florida Hospital
Orlando, Florida, United States, 32804 收起 <<
United States, Colorado
... 展开 >>
University of Colorado at Denver
Aurora, Colorado, United States, 80045
Denver Health and Hospital Authority (DHHA)
Denver, Colorado, United States, 80204
Department of Veteran Affairs Medical Center
Denver, Colorado, United States, 80220 收起 <<
Israel
... 展开 >> Hadassah - Hebrew University Medical Center
Not yet recruiting
Jerusalem, Israel, 91120
Contact: Giora Landesberg, Assoc. Prof. 97226777269 gio@cc.huji.ac.il
Principal Investigator: Giora Landesberg, Assoc. Prof. 收起 <<
United States, New York
... 展开 >>
University of Rochester
Recruiting
Rochester, New York, United States, 14642
Contact: Kristina J Cutter, MS 585-275-8819 Kris.Cutter@heart.rochester.edu
Contact: J
Sub-Investigator: Spencer Z Rosero, MD 收起 <<
Heart; Dysfunction Postoperati... 展开 >>ve, Cardiac Surgery 收起 <<
Phase 3
Terminated(lack of enrollment)
-
United States, Michigan
... 展开 >>
William Beaumont Hospital
Royal Oak, Michigan, United States, 48073
William Beaumont Hospital
Troy, Michigan, United States, 48085-1198 收起 <<
United States, California
... 展开 >>
UCSD Medical Center
Recruiting
San Diego, California, United States, 92103
Contact: Wendy Austin, MD 619-543-8213 waustin@ucsd.edu
Sub-Investigator: Wendy Austin, MD
Sub-Investigator: Ori Ben-Yehuda, MD
Sub-Investigator: Dan Blanchard, MD
Principal Investigator: Anthony DeMaria, MD 收起 <<
United States, New Mexico
... 展开 >>
University of New Mexico Health Science Center
Recruiting
Albuquerque, New Mexico, United States, 87131
Contact: Bina Ahmed, MD 505-272-2273 BAhmed@Salud.unm.edu
Contact: Lyra Salandre, BA 505-272-9898 LSalandre@Salud.unm.edu
Principal Investigator: Bina Ahmed, MD 收起 <<
United States, Maryland
... 展开 >>
University of Maryland
Baltimore, Maryland, United States, 21201
United States, Massachusetts
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
United States, Missouri
Washington University
Saint Louis, Missouri, United States, 63130
United States, Pennsylvania
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104 收起 <<
United States, California
... 展开 >>
127 S. San Vicente Blvd, Suite A9303
Los Angeles, California, United States, 90048
United States, Florida
University of Florida
Gainesville, Florida, United States, 32610 收起 <<
Adenocarcinoma of the Prostate... 展开 >>
Bone Metastases
Soft Tissue Metastases
Stage IIA Prostate Cancer
Stage IIB Prostate Cancer
Stage III Prostate Cancer
Stage IV Prostate Cancer 收起 <<
Not Applicable
Completed
-
United States, Colorado
... 展开 >>
University of Colorado Cancer Center
Aurora, Colorado, United States, 80045 收起 <<
United States, California
... 展开 >>
AMCR Institute
Escondido, California, United States, 92026
National Research Institute (NRI)
Los Angeles, California, United States, 90057
United States, Florida
SeaView Research Inc.
Miami, Florida, United States, 33126
Orlando Clinical Research Center (OCRC)
Orlando, Florida, United States, 32809
United States, Indiana
Midwest Institute For Clinical Research Inc. (MICR)
Indianapolis, Indiana, United States, 46260
United States, Kansas
Vince and Associates Clinical Research
Overland Park, Kansas, United States, 66212
United States, Kentucky
L-MARC Research Center
Louisville, Kentucky, United States, 40213
United States, New York
Rochester Clinical Research (RCR)
Rochester, New York, United States, 14609
United States, Texas
Cetero Research
San Antonio, Texas, United States, 78229 收起 <<
Israel
... 展开 >> Tel Aviv Medical Center
Recruiting
Tel Aviv, Israel
Contact: Sami Viskin, MD 972-3-6973311 samiviskin@gmail.com
Principal Investigator: Sami Viskin, MD
Sub-Investigator: Jesaia Benhorin, MD
Sub-Investigator: Arnon Adler, MD 收起 <<
United States, California
... 展开 >>
Westside Medical Associates of Los Angeles
Recruiting
Beverly Hills, California, United States, 90211
Contact: David Gallegos, RN 310-289-9955 david@westsidecardio.com
Principal Investigator: Gabriel Vorobiof, MD
Sub-Investigator: Norman Lepor, MD
Sub-Investigator: Hooman Madyoon, MD
Sub-Investigator: Gerald Pohost, MD
Sub-Investigator: Hee-won Kim, PhD 收起 <<
United States, Nevada
... 展开 >>
Cardiovascular Consultants of Nevada
Recruiting
Henderson, Nevada, United States, 89052
Cardiovascular Consultants of Nevada
Recruiting
Las Vegas, Nevada, United States, 89144
Cardiovascular Consultants of Nevada
Recruiting
Las Vegas, Nevada, United States, 89196 收起 <<
United States, Oklahoma
... 展开 >>
Oklahoma City VA Medical Center
Oklahoma City, Oklahoma, United States, 73104
OU Medical Center
Oklahoma City, Oklahoma, United States, 73104 收起 <<
United States, Maryland
... 展开 >>
Walter Reed National Military Medical Center
Recruiting
Bethesda, Maryland, United States, 20889
Contact: Michael S Cahill, MD 301-295-0394 michael.s.cahill.mil@health.mil
Principal Investigator: Michael S Cahill, MD 收起 <<
United States, Rhode Island
... 展开 >>
Kent Hospital
Recruiting
Warwick, Rhode Island, United States, 02886
Contact: Jennifer Gillis, NP JGillis@KentRI.org
Principal Investigator: Chester M Hedgepeth, MD, PhD 收起 <<
Terminated(Not enough patients... 展开 >> met study criteria for enrollment.) 收起 <<
-
United States, Alabama
... 展开 >>
Cardiology Associates
Fairhope, Alabama, United States, 36532
United States, Louisiana
Cardiovascular Institute of the South
Houma, Louisiana, United States, 70361
Cardiovascular Institute of the South
Lafayette, Louisiana, United States, 70503 收起 <<
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