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银杏内酯A /Ginkgolide A {[allProObj[0].p_purity_real_show]}

货号：A581449 同义名： BN-52020

Ginkgolide A is an antagonist of g-aminobutyric acid (GABA) with Ki of 14.5 μM and also can activate PAF. It is purified from the leaves of ginkgo biloba tree.

Ginkgolide A 化学结构
CAS号：15291-75-5

Ginkgolide A 3D分子结构
CAS号：15291-75-5

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Ginkgolide A 纯度/质量文件产品仅供科研

货号：A581449 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

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GABA受体亚型比较

产品名称	GABA receptor ↓ ↑	GABAA receptor ↓ ↑	其他靶点	纯度
Niflumic Acid	✔			98%
Ginkgolide A	++ GABA receptor, Ki: 14.5 μM			98%
Valproic acid sodium	✔		HDAC,Autophagy	97%
Flumazenil		✔		95%
Bemegride		✔		98%
Bicuculline		+++ GABAA receptor, IC50: 2 μM		98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ginkgolide A 生物活性

靶点

GABA receptor

GABA receptor, Ki:14.5 μM

描述

Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. Ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders^[3]. Ginkgolide-A (GA), a natural PXR ligand, attenuated BT in cirrhotic mice by abrogating inflammation along the gut-liver-axis, and by protecting small intestinal tight junctions (TJ)^[4]. GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro^[5]. GA is non-toxic at high concentrations in hepatocytes. Moreover, GA was found to inhibit cellular lipogenesis and lipid accumulation by causing mitochondrial oxidative stress. GA showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation^[6].

Ginkgolide A 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03772847	Intravenous Alteplase Thrombol... 展开 >>ysis Neurological Improving 收起 <<	Phase 4	Recruiting	December 1, 2019	China, Zhejiang ... 展开 >> Min Lou Recruiting Hangzhou, Zhejiang, China, 310000 Contact: Zexin Chen 13757118366 HREC2013@126.com 收起 <<
NCT02425436	Intrauterine Growth Restrictio... 展开 >>n (IUGR) 收起 <<	Phase 2	Completed	-	-

Ginkgolide A 参考文献

[1]Zhou H, Gao J, et al. Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models. Am J Physiol Renal Physiol. 2012 May 15;302(10):F1234-42.

[2]Wada K, Sasaki K, et al. Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull. 1993 Feb;16(2):210-2.

[3]Sarkar C, Quispe C, Jamaddar S, Hossain R, Ray P, Mondal M, Abdulwanis Mohamed Z, Sani Jaafaru M, Salehi B, Islam MT, Faizal Abdull Razis A, Martorell M, Pastene-Navarrete E, Sharifi-Rad J. Therapeutic promises of ginkgolide A: A literature-based review. Biomed Pharmacother. 2020 Dec;132:110908.

[4]Mohandas S, Vairappan B. Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis. Life Sci. 2020 Sep 15;257:118111.

[5]Li Y, Wu Y, Yao X, Hao F, Yu C, Bao Y, Wu Y, Song Z, Sun Y, Zheng L, Wang G, Huang Y, Sun L, Li Y. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4):794.

[6]Jeong HS, Kim KH, Lee IS, Park JY, Kim Y, Kim KS, Jang HJ. Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice. Biomed Pharmacother. 2017 Apr;88:625-634.

Ginkgolide A 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.24mL

2.45mL

1.22mL

24.49mL

4.90mL

2.45mL

Ginkgolide A 技术信息

CAS号	15291-75-5
分子式	C₂₀H₂₄O₉
分子量	408.399

别名	BN-52020
运输	蓝冰

存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C

溶解度

DMSO: 105 mg/mL(257.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

银杏内酯A /Ginkgolide A {[allProObj[0].p_purity_real_show]}

Ginkgolide A 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Ginkgolide A 质控信息

Ginkgolide A 生物活性

Ginkgolide A 临床研究

Ginkgolide A 参考文献

Ginkgolide A 实验方案

Ginkgolide A 技术信息

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银杏内酯A /Ginkgolide A {[allProObj[0].p_purity_real_show]}

Ginkgolide A 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Ginkgolide A 质控信息

Ginkgolide A 生物活性

Ginkgolide A 临床研究

Ginkgolide A 参考文献

Ginkgolide A 实验方案

Ginkgolide A 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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热门区域

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B

C

F

G

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Ginkgolide A 纯度/质量文件产品仅供科研