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/ Ginkgolide A

银杏内酯A /Ginkgolide A {[allProObj[0].p_purity_real_show]}

货号：A581449 同义名： BN-52020

Ginkgolide A is an antagonist of g-aminobutyric acid (GABA) with Ki of 14.5 μM and also can activate PAF. It is purified from the leaves of ginkgo biloba tree.

Ginkgolide A 化学结构 CAS号：15291-75-5
Ginkgolide A 化学结构
CAS号：15291-75-5
Ginkgolide A 3D分子结构
CAS号：15291-75-5
Ginkgolide A 化学结构 CAS号：15291-75-5
Ginkgolide A 3D分子结构 CAS号：15291-75-5
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Ginkgolide A 纯度/质量文件 产品仅供科研

货号：A581449 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 GABA receptor ↓ GABAA receptor ↓ 其他靶点 纯度
Niflumic Acid ✔ 98%
Ginkgolide A ++

GABA receptor, Ki: 14.5 μM

 		98%
Valproic acid sodium ✔ Autophagy,HDAC 97%
Flumazenil ✔ 95%
Bemegride ✔ 98%
Bicuculline +++

GABAA receptor, IC50: 2 μM

 		98+%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ginkgolide A 生物活性

靶点

  • GABA receptor

    GABA receptor, Ki:14.5 μM
描述 Ginkgolide A is a highly active platelet activating factor antagonist cage molecule which was isolated from the leaves of the Ginkgo biloba L. Ginkgolide A may be one of the potential therapeutic lead compounds, especially for the treatment of cardiovascular, hepatological, and neurological diseases and disorders[3]. Ginkgolide-A (GA), a natural PXR ligand, attenuated BT in cirrhotic mice by abrogating inflammation along the gut-liver-axis, and by protecting small intestinal tight junctions (TJ)[4]. GA could suppress the expression of pro-inflammatory mediators (cyclooxygenase-2 (COX-2) and nitric oxide (NO) and pro-inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β) in LPS-treated mouse peritoneal macrophages, mouse macrophage RAW264.7 cells, and differentiated human monocytes (dTHP-1) in vitro[5]. GA is non-toxic at high concentrations in hepatocytes. Moreover, GA was found to inhibit cellular lipogenesis and lipid accumulation by causing mitochondrial oxidative stress. GA showed hepatoprotective efficacy by inducing cellular lipoapoptosis and by inhibiting cellular inflammation[6].

Ginkgolide A 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03772847 Intravenous Alteplase Thrombol... 展开 >>ysis Neurological Improving 收起 << Phase 4 Recruiting December 1, 2019 China, Zhejiang ... 展开 >> Min Lou Recruiting Hangzhou, Zhejiang, China, 310000 Contact: Zexin Chen    13757118366    HREC2013@126.com 收起 <<
NCT02425436 Intrauterine Growth Restrictio... 展开 >>n (IUGR) 收起 << Phase 2 Completed - -

Ginkgolide A 参考文献

[1]Zhou H, Gao J, et al. Ginkgolide B inhibits renal cyst development in in vitro and in vivo cyst models. Am J Physiol Renal Physiol. 2012 May 15;302(10):F1234-42.

[2]Wada K, Sasaki K, et al. Isolation of bilobalide and ginkgolide A from Ginkgo biloba L. shorten the sleeping time induced in mice by anesthetics. Biol Pharm Bull. 1993 Feb;16(2):210-2.

[3]Sarkar C, Quispe C, Jamaddar S, Hossain R, Ray P, Mondal M, Abdulwanis Mohamed Z, Sani Jaafaru M, Salehi B, Islam MT, Faizal Abdull Razis A, Martorell M, Pastene-Navarrete E, Sharifi-Rad J. Therapeutic promises of ginkgolide A: A literature-based review. Biomed Pharmacother. 2020 Dec;132:110908.

[4]Mohandas S, Vairappan B. Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis. Life Sci. 2020 Sep 15;257:118111.

[5]Li Y, Wu Y, Yao X, Hao F, Yu C, Bao Y, Wu Y, Song Z, Sun Y, Zheng L, Wang G, Huang Y, Sun L, Li Y. Ginkgolide A Ameliorates LPS-Induced Inflammatory Responses In Vitro and In Vivo. Int J Mol Sci. 2017 Apr 10;18(4):794.

[6]Jeong HS, Kim KH, Lee IS, Park JY, Kim Y, Kim KS, Jang HJ. Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice. Biomed Pharmacother. 2017 Apr;88:625-634.

Ginkgolide A 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.45mL

0.49mL

0.24mL

12.24mL

2.45mL

1.22mL

24.49mL

4.90mL

2.45mL

Ginkgolide A 技术信息

CAS号15291-75-5
分子式C20H24O9
分子量 408.399
别名 BN-52020
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Store in freezer, under -20°C
溶解度

DMSO: 105 mg/mL(257.1 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Ginkgolide A | BN-52020 | Plant Standard | GABA Receptor | AmBeed-信号通路专用抑制剂 | Ginkgolide A 纯度/质量文件 | Ginkgolide A 亚型比较 | Ginkgolide A 生物活性 | Ginkgolide A 临床数据 | Ginkgolide A 参考文献 | Ginkgolide A 实验方案 | Ginkgolide A 技术信息

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