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(+)-Kavain

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Chemical Structure| 500-64-1 同义名 : NSC 112162;(+)-Kawain;Kavain, Kawain, NSC 112162;Kavain
CAS号 : 500-64-1
货号 : A428642
分子式 : C14H14O3
纯度 : 99%
分子量 : 230.259
MDL号 : MFCD00467093
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(217.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 (+)-Kavain, a primary kavalactone derived from Piper methysticum, exhibits anticonvulsive effects by attenuating vascular smooth muscle contraction via its interactions with voltage-dependent Na+ and Ca2+ channels[1]. (+)-Kavain is also known to bind to the α4β2δ GABAA receptor and enhance GABA efficacy[2]. As a therapeutic agent, (+)-Kavain is utilized in treating inflammatory diseases due to its well-studied anti-inflammatory properties[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.34mL

0.87mL

0.43mL

21.71mL

4.34mL

2.17mL

43.43mL

8.69mL

4.34mL
参考文献

[1]Bradić I, et al. [Hirschsprung's disease -- therapy and results]. Acta Chir Iugosl. 1975;22(2):183-95.

[2]Chua HC, et al. Kavain, the Major Constituent of the Anxiolytic Kava Extract, Potentiates GABAA Receptors: Functional Characteristics and Molecular Mechanism. PLoS One. 2016 Jun 22;11(6):e0157700.

[3]Tang X, et al. Kavain Inhibition of LPS-Induced TNF-α via ERK/LITAF. Toxicol Res (Camb). 2016 Jan 1;5(1):188-196.