There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Carboxyamidotriazole Orotate, the orotate salt of Carboxyamidotriazole (CAI), is recognized for its ability to inhibit signal transduction. It acts as a cytostatic blocker of nonvoltage-operated calcium channels and pathways dependent on these channels, showcasing antitumor, anti-inflammatory, and antiangiogenic properties[1].[2].
体内研究
When administered intraperitoneally at doses of 342 and 513 mg/kg on a once-daily schedule for two cycles, Carboxyamidotriazole Orotate exhibits significant antitumor activity in CML xenograft models[1].
体外研究
Carboxyamidotriazole Orotate curbs the proliferation of LAMA84R and K562R cell lines within a concentration range of 0.1-10 µM over 24-96 hours[1].
Carboxyamidotriazole Orotate also impedes the phosphorylation of CrkL, a target of Bcr-Abl kinase, with a significant reduction observed upon treatment with 5 µM of Carboxyamidotriazole Orotate[1].
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