Econazole is an imidazole-derived and broad-spectrum antimycotic agent with fungistatic properties, working by inhibiting biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability.
Econazole is an antifungal agent and a new PI3K (phosphatidylinositol-3-kinase) inhibitor and a potential drug that can be used in lung cancer treatment alone or in combination with cisplatin. Econazole significantly suppressed A549 tumor growth in nude mice[3]. Guinea-pigs infected with T. mentagrophytes, M. canis or C. albicans and treated topically or orally with econazole, were cured. In each of these tests the activity of econazole was compared with that of different reference drugs. Vaginal candidiasis in rats was cured after oral administration of econazole. Toxicity and teratogenicity studies in different laboratory animals indicate that econazole is well tolerated[4]. The econazole-bound TRPV5 (transient receptor potential vanilloid 5) structure adopts a closed conformation with a distinct lower gate that occludes Ca2+ permeation through the channel[5]. Moreover, econazole nitrate loaded transethosomes are effective to deliver econazole nitrate transdermally in a controlled fashion for effective elimination of cutaneous candidiasis[6].
United States, Arizona
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Tucson, Arizona, United States, 85741
United States, New York
New York, New York, United States, 10032
United States, Oregon
Portland, Oregon, United States, 97210 收起 <<
United States, Arizona
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Tucson, Arizona, United States, 85741
United States, New York
New York, New York, United States, 10032
United States, Oregon
Portland, Oregon, United States, 97210 收起 <<
United States, Florida
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Francisco Flores, MD
Miramar, Florida, United States, 33027
United States, Michigan
Daniel M. Stewart, DO
Clinton Township, Michigan, United States, 48038
United States, Nevada
Cyaandi Dove, DPM
Las Vegas, Nevada, United States, 89119
United States, Ohio
Robert S. Haber, MD
South Euclid, Ohio, United States, 44118
United States, South Carolina
Cynthia Strout, MD
Mt. Pleasant, South Carolina, United States, 29464
United States, Tennessee
Michael H. Gold, MD
Nashville, Tennessee, United States, 37215
United States, Texas
Jeffrey Adelglass, MD
Plano, Texas, United States, 75234 收起 <<
United States, California
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Sunil S. Dhawan, MD
Fremont, California, United States, 94538
United States, Delaware
Guy F. Webster, MD, PhD
Hockessin, Delaware, United States, 19707
United States, Florida
Marta I. Rendon, MD
Boca Raton, Florida, United States, 33486
Jonathan Kantor, MD
Jacksonville, Florida, United States, 32204
United States, Minnesota
Steven E. Kempers, MD
Fridley, Minnesota, United States, 55432
United States, Nebraska
Joel Schlessinger, MD
Omaha, Nebraska, United States, 68144
United States, Oregon
Phoebe Rich, MD
Portland, Oregon, United States, 97210
United States, Tennessee
Edward J. Primka III, MD
Knoxville, Tennessee, United States, 37917
United States, Texas
Michael T. Jarratt, MD
Austin, Texas, United States, 78759
William Abramovits, MD
Dallas, Texas, United States, 75230
United States, Virginia
David M. Pariser, MD, FAAD, FACP
Norfolk, Virginia, United States, 23507
United States, Wisconsin
Harry H. Sharata, MD, PhD
Madison, Wisconsin, United States, 53719 收起 <<
United States, California
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Stacy Smith, MD
San Diego, California, United States, 92123
United States, Michigan
Daniel Stewart, DO
Clinton Township, Michigan, United States, 48038
United States, Minnesota
Steven Kempers, MD
Fridley, Minnesota, United States, 55432
United States, Tennessee
Michael Gold, MD
Nashville, Tennessee, United States, 37215
United States, Texas
Michael Jarratt, MD
Austin, Texas, United States, 78759
United States, Utah
Leonard Swinyer, MD
Salt Lake City, Utah, United States, 84124 收起 <<
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