GDC-0276是一种选择性且具有口服活性的 NaV1.7 抑制剂，IC₅₀ 值为 0.4 nM。它耐受性良好，并展示了优异的药代动力学特征。GDC-0276 主要用于研究疼痛和成瘾性相关的神经性疾病。

NS383是一种有效且独特的 ASICs 抑制剂，能够抑制与酸敏感离子通道相关的疼痛信号传导，适用于病理性疼痛的治疗研究。

Evenamide是一种口服有效的电压门控钠通道阻滞剂，具有显著的抗精神分裂症和抗精神病活性，尤其在精神病的动物模型中表现出显著功效。

Flecainide Acetate is a class 1C antiarrhythmic drug especially used for the management of supraventricular arrhythmia and works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.

Dyclonine HCl is the HCl form of dyclonine which can reversibly bind to activated sodium channels on the neuronal membrane. It is an anaesthetic found in sucrets.

PF-01247324 is a selective Nav1.8 channel blocker with an IC50 of 196 nM.

Indoxacarb是一种广谱恶二嗪类杀虫剂，具有高杀虫活性和低哺乳动物毒性，能够阻断昆虫钠通道。

NHE3-IN-1 is a sodium/proton exchanger type 3 (NHE-3) inhibitor extracted from patent WO 2011019784 A1.

DS-1971a是一种选择性、口服有效的 NaV1.7 抑制剂，对 hNaV1.7 和 mNaV1.7 的 IC50 分别为 22.8 和 59.4 nM，用于疼痛研究。

PF-04885614是一种有效的 NaV1.8 钠离子通道抑制剂，具有潜力用于神经系统和神经发育疾病的研究，适用于疼痛管理以及神经功能障碍的研究。

BIX NHE1 Inhibitor is a potent and selective NHE1 inhibitor with IC50 of 31 nM.

Ropivacaine HCl, a local anaesthetic, can reversibly inhibit sodium ion influx and block impulse propagation along nerve fibres.

Ralfinamide mesylate is an blocker of Na+ channel with function of suppressing pain.

Nicainoprol is a sodium channels blocker which is used as an antiarrhythmic agent.

Licarbazepine, also known as BIA-2-005; GP-47779; LIC-477; LIC-477D; TRI-477, is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.

PF-04856264是一种选择性 Nav1.7 钠通道抑制剂，对人、小鼠、食蟹猴和狗的 Nav1.7 的 IC₅₀ 值分别为 28、131、19 和 42 nM。该化合物主要用于疼痛的缓解，尤其在慢性疼痛疾病中具有潜在的治疗应用。

Sodium Channel inhibitor 4是一种选择性钠离子通道抑制剂，主要作用于电压依赖性钠通道，通过抑制钠通道的活性，干扰动作电位的形成，从而调节神经元和肌肉细胞的兴奋性。钠通道抑制剂在治疗一系列神经性疾病中具有潜在的应用，如癫痫、心律失常和疼痛综合征。

Nav1.8-IN-4是 一种 Nav1.8 通道抑制剂，IC50 为 0.014 μM，可用于疼痛相关疾病的研究。

SLC13A5-IN-1是一种选择性 SLC13A5 抑制剂，具有潜在的应用于代谢和心血管疾病的研究。