sradipine is a calcium antagonist with marked vascular selectivity and, in practical terms, is devoid of cardiac effects. Both when used as single drug treatment and in combination with other agents, particularly beta-blockers, isradipine is well tolerated, does not cause metabolic disturbances and, apart from the typical dihydropyridine-type vascular adverse effects, e.g. flushing and ankle oedema, it does not cause any specific side effect[3]. The confirmation of its antihypertensive efficacy, along with its favourable haemodynamic profile and reversal of left ventricular hypertrophy, minimal effect on glucose and lipid metabolism, preservation of quality of life and good tolerability, makes isradipine a suitable drug for the treatment of most patients with mild to moderate hypertension[4]. Isradipine-induced acceleration of the Ca(v)1.2 current decay reflects enhanced fast voltage-dependent inactivation and not open channel block[2]. Isradipine in vitro attenuates beta amyloid oligomer toxicity by suppressing calcium influx into cytoplasm and by suppressing Ca(v)1.2 expression. Isradipine became bioavailable, lowered tau burden, and improved autophagy function in the brain[5]. Chronic isradipine treatment remodeled SNc DA neurons in a way that should not only diminish their vulnerability to mitochondrial challenges, but to autophagic stress as well[6].
Hypertension Secondary to Kidn... 展开 >>ey Transplant 收起 <<
Phase 2
Phase 3
Active, not recruiting
December 2018
United States, New York
... 展开 >>
Cohen Children's Medical Center of NY
New Hyde Park, New York, United States, 11040
United States, Pennsylvania
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19104 收起 <<
United States, California
... 展开 >>
Parkinson Institute
Sunnyvale, California, United States, 94805
United States, Connecticut
Institute for Neurodegenerative Disorders
New Haven, Connecticut, United States, 06510
United States, Florida
Mayo Clinic Jacksonville
Jacksonville, Florida, United States, 32224
University of Miami
Miami, Florida, United States, 33136
University of South Flordia
Tampa, Florida, United States, 33606
United States, Georgia
Emory University School of Medicine
Atlanta, Georgia, United States, 30329
United States, Hawaii
Pacific Health Institute
Honolulu, Hawaii, United States, 96817
United States, Illinois
Northwestern University
Chicago, Illinois, United States, 60611
Rush University Medical Center
Chicago, Illinois, United States, 60612
United States, Massachusetts
Boston University
Boston, Massachusetts, United States, 02118
United States, Michigan
Michigan State University
East Lansing, Michigan, United States, 48824
United States, Minnesota
Park Nicolet Clinic
Golden Valley, Minnesota, United States, 55427
University of Minnesota
Minneapolis, Minnesota, United States, 55455
United States, Missouri
Washington University
St. Louis, Missouri, United States, 63110
United States, New York
University of Rochester
Rochester, New York, United States, 14618
United States, Ohio
University of Cincinnati
Cincinnati, Ohio, United States, 45219
United States, Pennsylvania
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
United States, Tennessee
University of Tennessee
Memphis, Tennessee, United States, 38104
Canada, Ontario
Ottowa Hospital Civic Site
Ottawa, Ontario, Canada, K1Y 4E9
Toronto Western Hospital
Toronto, Ontario, Canada, M5T 2S8 收起 <<
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