Phenytoin is an inactive voltage-gatedsodium channel stabilizer.
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Phenytoin (5,5-Diphenylhydantoin) is a potent blocker of Voltage-gated Na+ channels (VGSCs). It is noted for its antiepileptic properties and its ability to reduce breast tumor growth and metastasis in mice[1].[2].
体内研究
In a specific study, Phenytoin (60 mg/kg; daily; for 28 days) was shown to decrease tumor growth in six-week-old female Rag2-/- Il2rg-/- mice implanted with MDA-MB-231 cells[1].
体外研究
As an antiepileptic medication, Phenytoin is effective in managing partial seizures and generalized tonic-clonic seizures, although it is not suitable for primary generalized seizures such as absence seizures or myoclonic seizures. Its mechanism involves a voltage-dependent blockade of voltage-gated sodium channels, which helps to prevent seizure activity[2].
Phenytoin exhibits low affinity for sodium channels that are in a resting state at hyperpolarized membrane potentials[3].
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