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/ Rufinamide

卢非酰胺 /Rufinamide {[allProObj[0].p_purity_real_show]}

货号：A193932 同义名： CGP 33101;E 2080

Rufinamide, an antiepileptic agent, is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).

Rufinamide 化学结构 CAS号：106308-44-5
Rufinamide 化学结构
CAS号：106308-44-5
Rufinamide 3D分子结构
CAS号：106308-44-5
Rufinamide 化学结构 CAS号：106308-44-5
Rufinamide 3D分子结构 CAS号：106308-44-5
规格 价格 会员价 库存 数量
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Rufinamide 纯度/质量文件 产品仅供科研

货号：A193932 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

全球学术期刊中引用的产品

• Nat. Biomed. Eng., 2024, 8, 1412-1424. Ambeed. [ A538667 , A631746 ]
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• BMC Cancer, 2024, 24(1): 1415. Ambeed. [ A809692 , A209020 ]
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产品名称 Sodium Channel ↓ 其他靶点 纯度
Tolperisone HCl ✔ 99%
Lamotrigine ✔ 98%
Vinpocetine ✔ 98%
Zonisamide ✔ 98%
Dronedarone Hydrochloride ✔ 95%
Procainamide hydrochloride ✔ 99%
Bupivacaine HCl ✔ 99+%
Benzocaine ✔ 98%
Carbamazepine ++

Sodium channel, IC50: 131 μM

 		98%
Quinidine sulfate dihydrate ✔ 98%
Ibutilide fumarate ✔ 99%+
Dibucaine HCl ✔ 99+%
Mexiletine HCl ✔ 99%
Phenytoin ✔ 99+%
Camostat Mesylate +++

epithelial sodium channel (ENaC), IC50: 50 nM

 		99%+
Levobupivacaine ✔ 97+%
Oxcarbazepine +

sodium channel, IC50: 160 μM

 		98%
Ambroxol 98+%
Primidone ✔ 99%
Propafenone ✔ 99%
A-803467 ++++

Na(V1.8) channel, IC50: 8 nM

 		99%+
Rufinamide ✔ 99%
Phenytoin sodium ✔ 98%
Proparacaine Hydrochloride +

Voltage-gated sodium channel, ED50: 3.4 mM

 		98+%
Riluzole ✔ 97%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Rufinamide 生物活性

靶点

  • Sodium Channel
描述 Rufinamide is an antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).

Rufinamide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02205931 Epilepsy Phase 4 Recruiting June 2019 United Kingdom ... 展开 >> Birmingham Children's Hospital Recruiting Birmingham, United Kingdom, B4 6NH Contact: Shakti Agrawal, MBBS    0044 1213338149    shakti.agrawal@bch.nhs.uk    Principal Investigator: Shakti Agrawal, MBBS          Bristol Royal Hospital for Children Recruiting Bristol, United Kingdom, BS2 8AE Contact: Andrew Mallick, FRCPCH          Principal Investigator: Andrew Mallick          Addenbrooke's Hospital Recruiting Cambridge, United Kingdom, CB2 0QQ Contact: Alasdair Parker, MA    0044 1223 245151    alasdair.parker@addenbrookes.nhs.uk    Principal Investigator: Alasdair Parker, MA          Lancashire Teaching Hospitals NHS Foundation Trust Recruiting Lancashire, United Kingdom Contact: Helen Basu       Helen.Basu@lthtr.nhs.uk    Principal Investigator: Helen Basu          Leeds Teaching Hospital Recruiting Leeds, United Kingdom, LS1 3EX Contact: Helen McCullagh, RCPCH    0044 113 243 2799    h.mccullagh@nhs.net    Principal Investigator: Helen McCullagh, RCPCH          Alder Hey Children's Hospital Recruiting Liverpool, United Kingdom, L12 2AP Contact: Rachel Kneen, BMBS    0044 151 2525163    rachel.kneen@liverpool.ac.uk    Principal Investigator: Rachel Kneen, BMBS          Great Ormond Street Hospital Recruiting London, United Kingdom, WC1N 3JH Contact: Christin Eltze, MD Res    0044 207 405 9200 ext 5438    christin.eltze@gosh.nhs.uk    Principal Investigator: Christin Eltze, MD Res          St George's University Hospitals NHS Foundation Trust Recruiting London, United Kingdom Contact: Penny Fallon       Penny.Fallon@stgeorges.nhs.uk    Principal Investigator: Penny Fallon          Royal Manchester Children's Hospital Recruiting Manchester, United Kingdom, M13 0JE Contact: Tim Martland, RCPCH    0044 161 276 1234    timothy.martland@cmft.nhs.uk    Principal Investigator: Tim Martland, RCPCH          The Newcastle Upon Tyne Hospitals NHS Foundation Trust Recruiting Newcastle upon Tyne, United Kingdom Contact: Anita Devlin       Anita.Devlin@nuth.nhs.uk    Principal Investigator: Anita Devlin          Sheffield Children's NHS Foundation Trust Recruiting Sheffield, United Kingdom Contact: Archana Desurkar       Archana.Desurkar@sch.nhs.uk    Principal Investigator: Archana Desurkar 收起 <<
NCT00552526 Epilepsy Ment... 展开 >>al Retardation 收起 << Phase 4 Unknown December 2013 Norway ... 展开 >> SSE, Nevrological dep. , Rikshospitalet University hospital Oslo, Norway 收起 <<
NCT01212458 - Completed - Switzerland ... 展开 >> University Hospital Zurich, Institut of Anaesthesiology Zurich, ZH, Switzerland, 8091 收起 <<

Rufinamide 参考文献

[1]Wright HM, Chen AV, et al. Pharmacokinetics of oral rufinamide in dogs. J Vet Pharmacol Ther. 2012 Dec;35(6):529-33.

[2]Williams ET, Carlson JE, et al. Investigation of the metabolism of rufinamide and its interaction with valproate. Drug Metab Lett. 2011 Dec;5(4):280-9.

Rufinamide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.20mL

0.84mL

0.42mL

20.99mL

4.20mL

2.10mL

41.98mL

8.40mL

4.20mL

Rufinamide 技术信息

CAS号106308-44-5
分子式C10H8F2N4O
分子量 238.194
别名 CGP 33101;E 2080;Inovelon.;Brand name: BANZEL;RUF 331
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Inert atmosphere,Room temperature
溶解度

DMSO: 50 mg/mL(209.91 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

IP 4% DMSO+2% Tween80+40% PEG300+water 1 mg/mL clear

PO 0.5% CMC-Na 62 mg/mL suspension

Tags: Rufinamide | 106308-44-5 | CGP 33101 | E 2080 | RUF 331 | CGP33101 | CGP-33101 | E2080 | E 2080 | E-2080 | RUF331 | RUF 331 | RUF-331 | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Rufinamide 纯度/质量文件 | Rufinamide 亚型比较 | Rufinamide 生物活性 | Rufinamide 临床数据 | Rufinamide 参考文献 | Rufinamide 实验方案 | Rufinamide 技术信息

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