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/ Lacidipine

拉西地平 /Lacidipine {[allProObj[0].p_purity_real_show]}

货号：A761993 同义名： GX 1048;GR-43659X

Lacidipine是一种 L 型钙通道拮抗剂，用于治疗高血压。

Lacidipine 化学结构 CAS号：103890-78-4
Lacidipine 化学结构
CAS号：103890-78-4
Lacidipine 3D分子结构
CAS号：103890-78-4
Lacidipine 化学结构 CAS号：103890-78-4
Lacidipine 3D分子结构 CAS号：103890-78-4
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Lacidipine 纯度/质量文件 产品仅供科研

货号：A761993 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 99%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.2, IC50: 110 nM

hCaV3.1, IC50: 50 nM

 		99%+
Dronedarone Hydrochloride ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ROS,ERK,p38 MAPK 99%+
Fasudil HCl ✔ Rho,PKA 98%
ML-9 ✔ MLCK,Akt 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 98%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 99%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		99%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 99%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 99%
NP118809 +

N-type Ca2+ channel, IC50: 0.11 μM

L-type calcium channel, IC50: 12.2 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 99%
Cinepazide Maleate ✔ 99% (HPLC)
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ Akt,p38 MAPK 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Lacidipine 生物活性

靶点

  • Calcium Channel
描述 Lacidipine, a novel third-generation dihydropyridine calcium channel blocker used for hypertension. Lacidipine protects HKCs (human kidney cell) against apoptosis induced by ATP (adenosine triphosphate) depletion and recovery by regulating the caspase-3 pathway[3]. In addition to calcium channel-modulated vasodilation, lacidipine displays antioxidant activity greater than that of other dihydropyridine calcium antagonists. Lacidipine was effective in elderly patients (including those with isolated systolic hypertension), African Nigerian patients and patients with concurrent type 2 diabetes mellitus. Lower atherosclerotic progression and plaque formation with lacidipine compared with atenolol in patients completing the full 4 years of the study[4]. Lacidipine showed a significant reduction in elevated systolic blood pressure together with a great protection of ALT (alanine amine transferase) and SOD enzymes from the destructive effects of irradiation and hypertension in irradiated, hypertensive and lacidipine-treated rats[5]. Lacidipine-modified EPCs (Endothelial progenitor cells) via a partially CXCR4 (CXC chemokine receptor four) signaling contribute to enhanced endothelial repair capacity in hypertension[2]. In addition, lacidipine attenuates depression-like symptoms in reserpine-treated mice[6].

Lacidipine 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01587742 - Completed - -
NCT00460915 Hypertension Phase 4 Completed - Korea, Republic of ... 展开 >> Korea University Guro Hospital Seoul, Korea, Republic of, 152-703 收起 <<
NCT02218684 Healthy Phase 1 Completed - -

Lacidipine 参考文献

[1]Bernard E, Mialou V, et al. [Lacidipine efficacy and safety for high blood pressure treatment in pediatric oncohematology] . Arch Pediatr. 2014 Oct;21(10):1101-5.

[2]Liu X, Zhang GX, Zhang XY, et al. Lacidipine improves endothelial repair capacity of endothelial progenitor cells from patients with essential hypertension. Int J Cardiol. 2013;168(4):3317‐3326

[3]Zhang A, Fu S, Chen L, et al. Lacidipine attenuates apoptosis via a caspase-3 dependent pathway in human kidney cells. Cell Physiol Biochem. 2013;32(4):1040‐1049

[4]McCormack PL, Wagstaff AJ. Lacidipine: a review of its use in the management of hypertension. Drugs. 2003;63(21):2327‐2356

[5]Kamal SM. Possible hepatoprotective effects of lacidipine in irradiated DOCA-salt hypertensive albino rats. Pak J Biol Sci. 2013;16(21):1353‐1357

[6]Khurana K, Bansal N. Lacidipine attenuates reserpine-induced depression-like behavior and oxido-nitrosative stress in mice. Naunyn Schmiedebergs Arch Pharmacol. 2019;392(10):1265‐1275

Lacidipine 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

10.98mL

2.20mL

1.10mL

21.95mL

4.39mL

2.20mL

Lacidipine 技术信息

CAS号103890-78-4
分子式C26H33NO6
分子量 455.543
别名 GX 1048;GR-43659X;Motens;Lacimen;Lacipil;SN-305
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Keep in dark place,Inert atmosphere,2-8°C
溶解方案

DMSO: 50 mg/mL(109.76 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用； 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
方案一
方案二
动物实验配方

Tags: Lacidipine | 103890-78-4 | Membrane Transporter/Ion Channel | Neuronal Signaling | Metabolic Enzyme/Protease | Immunology/Inflammation | NF-κB | Apoptosis | Calcium Channel | Reactive Oxygen Species | Caspase | Apoptosis | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Lacidipine 纯度/质量文件 | Lacidipine 亚型比较 | Lacidipine 生物活性 | Lacidipine 临床数据 | Lacidipine 参考文献 | Lacidipine 实验方案 | Lacidipine 技术信息

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