Nimodipine | BAY-e 9736 | Drug Standard | Neurotransmitter | Calcium Channel | Autophagy

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尼莫地平 /Nimodipine 95%

货号：A742694 同义名： BAY-e 9736

Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.

Nimodipine 化学结构
CAS号：66085-59-4

Nimodipine 3D分子结构
CAS号：66085-59-4

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Nimodipine 纯度/质量文件产品仅供科研

货号：A742694 标准纯度： 95% 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • Cell,2024. Ambeed. [ A125712 ]; • Cancer Discov., 2024. Ambeed. [ A285925 ]; • JMC, 2024, 67(17): 14974-14985. Ambeed. [ A288696 ]; • JMC, 2024, 67(17): 15061-15079. Ambeed. [ A524399 , A633512 , A144280 , A174613 ]; • EJNMMI Radiopharm. Chem., 2024, 9, 61. Ambeed. [ A1257961 , A622068 ]; 更多 >

自噬亚型比较
Calcium Channel 亚型比较

产品名称	Autophagy ↓ ↑	其他靶点	纯度
SBI-0206965	+++ ULK2, IC50: 711 nM ULK1, IC50: 108 nM		97%
Hydroxychloroquine sulfate	✔		99%
Valproic acid sodium	✔	HDAC	97%
PFK-015	++ PFKFB3, IC50: 207 nM		99%+
MRT68921 hydrochloride	++++ ULK2, IC50: 1.1 nM ULK1, IC50: 2.9 nM		99%+
ROC-325	✔		99%+
Autophinib	+++ Autophagy, IC50: 40 nM		97%
Lys05	✔		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

产品名称	Ca2+ channel-like protein ↓ ↑	Calcium Channel ↓ ↑	Cav 2.2 ↓ ↑	其他靶点	纯度
CDC25B-IN-2	✔			Akt	99%+
Clevidipine		✔			97%
Verapamil HCl		✔			99%
Amlodipine		✔			99%
Amlodipine maleate		✔			98%
(+)-cis-Diltiazem HCl		✔			95%
Zegocractin		++ Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM			99%+
Tanshinone IIA sulfonate sodium		✔			98%
Ulixacaltamide		++ hCaV3.2, IC50: 110 nM hCaV3.1, IC50: 50 nM			99%+
Dronedarone Hydrochloride		✔			95%
Nitrendipine		+ Calcium channel, IC50: 95 nM			98%
Efonidipine HCl monoethanolate		✔			98%
Cinnarizine		✔			98%
SEA0400		++ NCX, IC50: 33 nM		ROS,ERK,p38 MAPK	99%+
Fasudil HCl		✔		Rho,PKA	98%
ML-9		✔		MLCK,Akt	99%+
Flunarizine 2HCl		+ Calcium channel, Ki: 68 nM			95%
Lomerizine 2HCl		✔			98%
Efonidipine		✔			98%
Levamlodipine		✔			97%
Nisoldipine		++ L-type Cav1.2, IC50: 10 nM			97%
Isradipine		✔			98%
Lacidipine		✔			98%
Lercanidipine		✔			98%
Loureirin B		✔		Potassium Channel	99%+
Tetracaine HCl		✔			98%
Manidipine		+++ Calcium channel, IC50: 2.6 nM			98%
Manidipine Dihydrochlorid		+++ Calcium channel, IC50: 2.6 nM			98%
Nicardipine		✔			98%
Wilforgine		✔			98+%
Econazole		✔			99%+
Ginsenoside Rd		✔		NF-κB	98%
Fendiline HCl		✔			98+%
Mesaconitine		✔			98%
Tetrandrine		✔			95%
Nifedipine		✔			95%
Nilvadipine		++++ Calcium channel, IC50: 0.03 nM			98%
Barnidipine		++++ [³H]nitrendipine, Ki: 0.21 nM			95+%
Azelnidipine		✔			97%
Levetiracetam		✔			98%
Nimodipine		✔			95%
Benidipine HCl		✔			98%
Pinaverium bromide		✔			98%
Pranidipine		✔			98%
NP118809		+ L-type calcium channel, IC50: 12.2 μM N-type Ca2+ channel, IC50: 0.11 μM			98%
Amlodipine Besylate		+++ Calcium channel, IC50: 1.9 nM			97%
Cilnidipine		✔			98%
Cinepazide Maleate		✔			98%
Terfenadine		✔			98%
YM-58483		✔			99%+
Ranolazine		✔			98%
Praeruptorin A		✔		p38 MAPK,Akt	98%
Ranolazine 2HCl		✔			98%
Felodipine		++++ L-type calcium channel, IC50: 0.15 nM			98%
PD173212		+++ N-type Ca2+ channel, IC50: 36 nM			98%
Levamlodipine besylate		✔			97%
Carboxyamidotriazole Orotate		✔			98%
IGS-1.76		✔			98+%
WH-4-023		++++ Cav 2.2, IC50: 0.001 μM	++++ Cav 2.2, IC50: 0.001 μM		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Nimodipine 生物活性

靶点

Calcium Channel

描述

L-type calcium (Ca²⁺) channel mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm. Calcium channel also plays an important role in excitation-contraction coupling in the heart and is required for normal heart development and normal regulation of heart rhythm. Calcium channel is required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Calcium channel blockers are in clinical use in the fields of diseases such as hypertension, angina. Nimodipine is a L-type calcium channel antagonist. In an experiment utilizing rabbit hippocampal CA1 neurons derived from young or aging rabbits, the time course of calcium action potentials (AP) were tested. Nimodipine decreased the plateau phase of the calcium AP at concentrations as low as 100 nM in aging neurons and 10 μM in young neurons. Switching to higher concentrations of nimodipine did not reveal any substantially increased block of the calcium AP plateau phase^[3]. In another report, perilymph spaces of guinea pig cochleae were perfused with artificial perilymph solutions containing 0.1 - 10 μM nimodipine at a rate of 2.5 microliters/min for 10 min. Cochlear perfusion of nimodipine resulted in reversible, dose-related suppression of the compound action potential of the auditory nerve, a prolongation of N1 latency at suprathreshold levels, an elevated CAP threshold, a decrease in N1 latency at a constant amplitude measured at CAP threshold, a reduction in cochlear microphonics, and a reduction of the negative summating potential to a point where it became positive, while the endocochlear potential was not affected^[4]. Based on an animal experiment recording nose-poke response to test cocaine and morphine intravenous self-administration in drug-naive mice, a single injection of nimodipine administrated s.c. 80 min prior to the experiment at the doses between 5 – 20 mg/kg inhibited nose-poke response of mice in a dose-related manner. The ED50s of nimodipine against cocaine and morphine self-administration was 14.5 mg/kg and 11.4 mg/kg, respectively^[5].

Nimodipine 动物研究

Dose	Rat: 5 mg/kg - 15 mg/kg^[3] (i.p.); 0.001 mg/kg = 0.1 mg/kg^[4] (i.v.)
Administration	i.p., i.v.

Nimodipine 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03434314	Aortic Aneurysm, Thoracoabdomi... 展开 >>nal 收起 <<	Not Applicable	Not yet recruiting	September 2021	Austria ... 展开 >> Medizinische Universität Innsbruck Not yet recruiting Innsbruck, Austria Contact: Michael Grimm, Prof. Dr. +43 512 504 22500 michael.grimm@tirol-kliniken.at Contact: Johannes Holfeld, Dr. johannes.holfeld@i-med.ac.at Herzzentrum Hietzing Not yet recruiting Vienna, Austria Contact: Martin Grabenwöger, Prof. Dr. +43 1 4020585 Martin.Grabenwoeger@wienkav.at Contact: Gabriel Weiss, Dr. gabriel.weiss@wienkav.at France University Hospital of Bordeaux Not yet recruiting Bordeaux, France Contact: Eric Ducasse, Prof. Dr. +335 56 79 55 25 eric.ducasse@chu-bordeaux.fr Marie Lannelongue Hospital Not yet recruiting Le Plessis-Robinson, France Contact: Stephan Haulon, Prof. Dr. Germany Uniklinik RWTH Aachen Not yet recruiting Aachen, Germany Contact: Michael Jacobs, Prof. Dr. +49 241 8085197 mjacobs@ukaachen.de Contact: Drosos Kotelis, Dr. dkotelis@ukaachen.de Deutsches Herzzentrum Berlin Not yet recruiting Berlin, Germany Contact: Volkmar Falk, Prof. Dr. falk@dhzb.de Contact: Semih Buz, Dr. buz@dhzb.de Universitätsklinikum Düsseldorf Not yet recruiting Düsseldorf, Germany Contact: Hubert Schelzig, Prof. Dr. 0049 211 81 07211 hubert.schelzig@med.uni-duesseldorf.de Contact: Alexander Oberhuber, Dr. Alexander.Oberhuber@med.uni-duesseldorf.de Westdeutsches Herz und Gefäßzentrum Essen Not yet recruiting Essen, Germany Contact: Heinz Jakob, Prof. Dr. +49 201 723 4901 heinz.jakob@uk-essen.de Contact: Konstantinos Tsagakis, Dr. Konstantinos.Tsagakis@uk-essen.de Universitäts-Herzzentrum Freiburg/ Bad Krozingen Not yet recruiting Freiburg, Germany Contact: Martin Czerny, Prof. Dr. +49 7633 402 6216 martin.czerny@universitaets-herzzentrum.de Herzzentrum Hamburg Not yet recruiting Hamburg, Germany Contact: Tilo Kölbel, Prof. Dr. +49 40 7410 58609 t.koelbel@uke.de Medizinische Hochschule Hannover Not yet recruiting Hanover, Germany Contact: Axel Haverich, Prof. Dr. 0049 511- 532 6580 haverich.axel@mh-hannover.de Contact: Malakh Shrestha, Prof. Dr. 0049 511- 532 6238 Shrestha.Malakh.lal@mh-hannover.de Universitätsklinikum Heidelberg Not yet recruiting Heidelberg, Germany Contact: Dittmar Böckler, Prof. Dr. 0049 6221 56 6249 dittmar.boeckler@med.uni-heidelberg.de Contact: Moritz Bischoff, Dr. moritz.bischoff@med.uni-heidelberg.de Herzzentrum Leipzig Not yet recruiting Leipzig, Germany Contact: Christian D Etz, Prof. Dr. +49 341 865 251007 christian.etz@medizin.uni-leipzig.de UniversitätskIinikum Leipzig Not yet recruiting Leipzig, Germany Contact: Scheinert Dierk, Prof.Dr. +49 341 97 18770 dierk.scheinert@medizin.uni-leipzig.de Klinikum rechts der Isar (TU München) Not yet recruiting Munich, Germany Contact: Hans-Henning Eckstein, Prof. Dr. +49 89 4140 9244 H.H.Eckstein@lrz.tum.de Contact: Sarah Geisbüsch, Dr. sarah.geisbuesch@mri.tum.de Klinikum der Universität München (LMU) Not yet recruiting München, Germany Contact: Maximilian Luehr, Dr. + 49 89 4400 72436 maximilian.luehr@med.uni-muenchen.de St. Franziskus-Hospital GmbH Not yet recruiting Münster, Germany Contact: Giovanni Torsello, Prof. Dr. 0049 251 935-3933 giovanni.torsello@ukmuenster.de Contact: Theodosios Bisdas, Dr. theodosios.bisdas@sfh-muenster.de Paracelsus Universität - Klinikum Nürnberg Not yet recruiting Nuremberg, Germany Contact: Eric Verhoeven, Prof. Dr. 0049 911 398 117004 eric.verhoeven@klinikum-nuernberg.de Contact: Athanasios Katsargyris, Dr. Athanasios.Katsargyris@klinikum-nuernberg.de Universitätsklinikum Regensburg Not yet recruiting Regensburg, Germany Contact: Karin Pfister, Prof. Dr. +49 941 944 6911 Karin.Pfister@klinik.uni-regensburg.de Contact: Piotr Kasprzak, Prof. Dr. piotr.kasprzak@ukr.de Universitätsklinikum Tübingen Not yet recruiting Tübingen, Germany Contact: Christian Schlensak, Prof. Dr. 0049 7071 29 86638 christian.schlensak@med.uni-tuebingen.de Contact: Mario Lescan, Dr. mario.lescan@med.uni-tuebingen.de Italy S.Orsola-Malpighi Hospital Not yet recruiting Bologna, Italy Contact: Davide Pacini, Prof. Dr. +39 051 6363329 davide.pacini@unibo.it Ospedale San Raffaele SRL Not yet recruiting Milano, Italy Contact: Roberto Chiesa, Prof. Dr. +39 02 2643 7148 chiesa.roberto@unisr.it Contact: Germano Melissano, Prof. Dr. +39 02 2643 7148 melissano.germano@hsr.it Netherlands Maastricht University Medical Center Not yet recruiting Maastricht, Netherlands Contact: Michael Jacobs, Prof. Dr. m.jacobs@mumc.nl Contact: Barend Mees, Dr. +31 43 3877478 barend.mees@mumc.nl Poland Medical University of Warsaw Not yet recruiting Warsaw, Poland Contact: Tomasz Jakimowicz, Dr. tomj@wum.edu.pl Silesian Center for Heart Diseases Not yet recruiting Zabrze, Poland Contact: Marian Zembala, Prof. Dr. +48 323733689 m.zembala@sccs.pl; sek.kch@sccs.pl Contact: Maciej K Kolowca, Dr. maciej@kolowca.eu Sweden Lund University Hospital Malmoe Not yet recruiting Malmö, Sweden Contact: Tim Resch, Dr. tim.resch@med.lu.se Örebro University Hospital Not yet recruiting Örebro, Sweden Contact: Thomas Larzon, Prof. Dr. thomas.larzon@regionorebrolan.se Switzerland Bern University Hospital Not yet recruiting Bern, Switzerland Contact: Jürg Schmidli, Prof. Dr. +41 31 632 26 02 juerg.schmidli@insel.ch United Kingdom St Bartholomews Hospital Not yet recruiting London, United Kingdom Contact: Aung Y Oo, Prof. Dr. AungYe.OO@Bartshealth.nhs.uk 收起 <<
NCT03718780	Pulmonary Disease, Chronic Obs... 展开 >>tructive Lung Diseases, Interstitial Chronic Heart Failure Pulmonary Arterial Hypertension Hyperventilation Syndrome Healthy 收起 <<	Not Applicable	Not yet recruiting	March 2020	France ... 展开 >> Service de pneumologie Not yet recruiting Béthune, France, 62408 Contact: Frédéric BART Principal Investigator: Frédéric BART Service de pneumologie CHMS Not yet recruiting Chambéry, France, 73000 Contact: Serge Kouzan Sub-Investigator: Julien PERNOT Sub-Investigator: Marie COUDURIER Principal Investigator: Serge KOUZAN Service de réanimation médicale - CHMS Not yet recruiting Chambéry, France, 73000 Contact: Jean-Marc THOURET Jean-Marc.Thouret@ch-metropole-savoie.fr Contact: Vincent PEIGNE vincent.peigne@ch-metropole-savoie.fr Sub-Investigator: Jean-Marc THOURET Principal Investigator: Vincent PEIGNE Service de Pneumologie CHU Grenoble Not yet recruiting La Tronche, France, 38700 Contact: Bernard AGUILANIU Principal Investigator: Bernard AGUILANIU 收起 <<
NCT00001478	-		Completed	-	United States, Maryland ... 展开 >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 收起 <<

Nimodipine 参考文献

[1]Bork K, Wurm F, et al. Neuroprotective and neuroregenerative effects of nimodipine in a model system of neuronal differentiation and neurite outgrowth. Molecules. 2015 Jan 9;20(1):1003-13.

[2]Koskimaki J, Matsui N, et al. Nimodipine activates TrkB neurotrophin receptors and induces neuroplastic and neuroprotective signaling events in the mouse hippocampus and prefrontal cortex. Cell Mol Neurobiol. 2015 Mar;35(2):189-96.

[3]Moyer JR Jr, Disterhoft JF. Nimodipine decreases calcium action potentials in rabbit hippocampal CA1 neurons in an age-dependent and concentration-dependent manner. Hippocampus. 1994 Feb;4(1):11-7.

[4]Bobbin RP, Jastreboff PJ, Fallon M, Littman T. Nimodipine, an L-channel Ca2+ antagonist, reverses the negative summating potential recorded from the guinea pig cochlea. Hear Res. 1990 Jul;46(3):277-87.

[5]Kuzmin A, Zvartau E, Gessa GL, Martellotta MC, Fratta W. Calcium antagonists isradipine and nimodipine suppress cocaine and morphine intravenous self-administration in drug-naive mice. Pharmacol Biochem Behav. 1992 Mar;41(3):497-500.

Nimodipine 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.19mL

23.90mL

4.78mL

2.39mL

Nimodipine 技术信息

CAS号	66085-59-4
分子式	C₂₁H₂₆N₂O₇
分子量	418.44

别名	BAY-e 9736
运输	蓝冰

存储条件

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 105 mg/mL(250.93 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03434314	Aortic Aneurysm, Thoracoabdomi... 展开 >>nal 收起 <<	Not Applicable	Not yet recruiting	September 2021	Austria ... 展开 >> Medizinische Universität Innsbruck Not yet recruiting Innsbruck, Austria Contact: Michael Grimm, Prof. Dr. +43 512 504 22500 michael.grimm@tirol-kliniken.at Contact: Johannes Holfeld, Dr. johannes.holfeld@i-med.ac.at Herzzentrum Hietzing Not yet recruiting Vienna, Austria Contact: Martin Grabenwöger, Prof. Dr. +43 1 4020585 Martin.Grabenwoeger@wienkav.at Contact: Gabriel Weiss, Dr. gabriel.weiss@wienkav.at France University Hospital of Bordeaux Not yet recruiting Bordeaux, France Contact: Eric Ducasse, Prof. Dr. +335 56 79 55 25 eric.ducasse@chu-bordeaux.fr Marie Lannelongue Hospital Not yet recruiting Le Plessis-Robinson, France Contact: Stephan Haulon, Prof. Dr. Germany Uniklinik RWTH Aachen Not yet recruiting Aachen, Germany Contact: Michael Jacobs, Prof. Dr. +49 241 8085197 mjacobs@ukaachen.de Contact: Drosos Kotelis, Dr. dkotelis@ukaachen.de Deutsches Herzzentrum Berlin Not yet recruiting Berlin, Germany Contact: Volkmar Falk, Prof. Dr. falk@dhzb.de Contact: Semih Buz, Dr. buz@dhzb.de Universitätsklinikum Düsseldorf Not yet recruiting Düsseldorf, Germany Contact: Hubert Schelzig, Prof. Dr. 0049 211 81 07211 hubert.schelzig@med.uni-duesseldorf.de Contact: Alexander Oberhuber, Dr. Alexander.Oberhuber@med.uni-duesseldorf.de Westdeutsches Herz und Gefäßzentrum Essen Not yet recruiting Essen, Germany Contact: Heinz Jakob, Prof. Dr. +49 201 723 4901 heinz.jakob@uk-essen.de Contact: Konstantinos Tsagakis, Dr. Konstantinos.Tsagakis@uk-essen.de Universitäts-Herzzentrum Freiburg/ Bad Krozingen Not yet recruiting Freiburg, Germany Contact: Martin Czerny, Prof. Dr. +49 7633 402 6216 martin.czerny@universitaets-herzzentrum.de Herzzentrum Hamburg Not yet recruiting Hamburg, Germany Contact: Tilo Kölbel, Prof. Dr. +49 40 7410 58609 t.koelbel@uke.de Medizinische Hochschule Hannover Not yet recruiting Hanover, Germany Contact: Axel Haverich, Prof. Dr. 0049 511- 532 6580 haverich.axel@mh-hannover.de Contact: Malakh Shrestha, Prof. Dr. 0049 511- 532 6238 Shrestha.Malakh.lal@mh-hannover.de Universitätsklinikum Heidelberg Not yet recruiting Heidelberg, Germany Contact: Dittmar Böckler, Prof. Dr. 0049 6221 56 6249 dittmar.boeckler@med.uni-heidelberg.de Contact: Moritz Bischoff, Dr. moritz.bischoff@med.uni-heidelberg.de Herzzentrum Leipzig Not yet recruiting Leipzig, Germany Contact: Christian D Etz, Prof. Dr. +49 341 865 251007 christian.etz@medizin.uni-leipzig.de UniversitätskIinikum Leipzig Not yet recruiting Leipzig, Germany Contact: Scheinert Dierk, Prof.Dr. +49 341 97 18770 dierk.scheinert@medizin.uni-leipzig.de Klinikum rechts der Isar (TU München) Not yet recruiting Munich, Germany Contact: Hans-Henning Eckstein, Prof. Dr. +49 89 4140 9244 H.H.Eckstein@lrz.tum.de Contact: Sarah Geisbüsch, Dr. sarah.geisbuesch@mri.tum.de Klinikum der Universität München (LMU) Not yet recruiting München, Germany Contact: Maximilian Luehr, Dr. + 49 89 4400 72436 maximilian.luehr@med.uni-muenchen.de St. Franziskus-Hospital GmbH Not yet recruiting Münster, Germany Contact: Giovanni Torsello, Prof. Dr. 0049 251 935-3933 giovanni.torsello@ukmuenster.de Contact: Theodosios Bisdas, Dr. theodosios.bisdas@sfh-muenster.de Paracelsus Universität - Klinikum Nürnberg Not yet recruiting Nuremberg, Germany Contact: Eric Verhoeven, Prof. Dr. 0049 911 398 117004 eric.verhoeven@klinikum-nuernberg.de Contact: Athanasios Katsargyris, Dr. Athanasios.Katsargyris@klinikum-nuernberg.de Universitätsklinikum Regensburg Not yet recruiting Regensburg, Germany Contact: Karin Pfister, Prof. Dr. +49 941 944 6911 Karin.Pfister@klinik.uni-regensburg.de Contact: Piotr Kasprzak, Prof. Dr. piotr.kasprzak@ukr.de Universitätsklinikum Tübingen Not yet recruiting Tübingen, Germany Contact: Christian Schlensak, Prof. Dr. 0049 7071 29 86638 christian.schlensak@med.uni-tuebingen.de Contact: Mario Lescan, Dr. mario.lescan@med.uni-tuebingen.de Italy S.Orsola-Malpighi Hospital Not yet recruiting Bologna, Italy Contact: Davide Pacini, Prof. Dr. +39 051 6363329 davide.pacini@unibo.it Ospedale San Raffaele SRL Not yet recruiting Milano, Italy Contact: Roberto Chiesa, Prof. Dr. +39 02 2643 7148 chiesa.roberto@unisr.it Contact: Germano Melissano, Prof. Dr. +39 02 2643 7148 melissano.germano@hsr.it Netherlands Maastricht University Medical Center Not yet recruiting Maastricht, Netherlands Contact: Michael Jacobs, Prof. Dr. m.jacobs@mumc.nl Contact: Barend Mees, Dr. +31 43 3877478 barend.mees@mumc.nl Poland Medical University of Warsaw Not yet recruiting Warsaw, Poland Contact: Tomasz Jakimowicz, Dr. tomj@wum.edu.pl Silesian Center for Heart Diseases Not yet recruiting Zabrze, Poland Contact: Marian Zembala, Prof. Dr. +48 323733689 m.zembala@sccs.pl; sek.kch@sccs.pl Contact: Maciej K Kolowca, Dr. maciej@kolowca.eu Sweden Lund University Hospital Malmoe Not yet recruiting Malmö, Sweden Contact: Tim Resch, Dr. tim.resch@med.lu.se Örebro University Hospital Not yet recruiting Örebro, Sweden Contact: Thomas Larzon, Prof. Dr. thomas.larzon@regionorebrolan.se Switzerland Bern University Hospital Not yet recruiting Bern, Switzerland Contact: Jürg Schmidli, Prof. Dr. +41 31 632 26 02 juerg.schmidli@insel.ch United Kingdom St Bartholomews Hospital Not yet recruiting London, United Kingdom Contact: Aung Y Oo, Prof. Dr. AungYe.OO@Bartshealth.nhs.uk 收起 <<
NCT03718780	Pulmonary Disease, Chronic Obs... 展开 >>tructive Lung Diseases, Interstitial Chronic Heart Failure Pulmonary Arterial Hypertension Hyperventilation Syndrome Healthy 收起 <<	Not Applicable	Not yet recruiting	March 2020	France ... 展开 >> Service de pneumologie Not yet recruiting Béthune, France, 62408 Contact: Frédéric BART Principal Investigator: Frédéric BART Service de pneumologie CHMS Not yet recruiting Chambéry, France, 73000 Contact: Serge Kouzan Sub-Investigator: Julien PERNOT Sub-Investigator: Marie COUDURIER Principal Investigator: Serge KOUZAN Service de réanimation médicale - CHMS Not yet recruiting Chambéry, France, 73000 Contact: Jean-Marc THOURET Jean-Marc.Thouret@ch-metropole-savoie.fr Contact: Vincent PEIGNE vincent.peigne@ch-metropole-savoie.fr Sub-Investigator: Jean-Marc THOURET Principal Investigator: Vincent PEIGNE Service de Pneumologie CHU Grenoble Not yet recruiting La Tronche, France, 38700 Contact: Bernard AGUILANIU Principal Investigator: Bernard AGUILANIU 收起 <<
NCT00001478	-		Completed	-	United States, Maryland ... 展开 >> National Institute of Mental Health (NIMH) Bethesda, Maryland, United States, 20892 收起 <<
NCT01715662	Lower Limb Amputation	Not Applicable	Completed	-	Canada, British Columbia ... 展开 >> Holy Family Hospital Vancouver, British Columbia, Canada, V5P 3L6 GF Strong Vancouver, British Columbia, Canada, V5Z 2G9 St. Paul's Hospital Vancouver, British Columbia, Canada, V6Z 1Y6 收起 <<
NCT02774031	Male Urogenital Diseases ... 展开 >> Female Urogenital Diseases 收起 <<	Not Applicable	Completed	-	Norway ... 展开 >> Department of Anesthesia, St.Olavs University Hospital Trondheim, Norway, 7006 收起 <<
NCT03022162	-		Not yet recruiting	August 31, 2017	-
NCT02545777	Acute Gouty Arthritis	Phase 2	Unknown	-	China, Beijing ... 展开 >> No.3 Hospital Affiliated to Beijing University of Chinese Medicine Recruiting Beijing, Beijing, China, 100029 Contact: Lou Xi Nen, Doctor 13601181885 13601181885@163.com Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Recruiting Beijing, Beijing, China, 100700 Contact: Zhao Jiu Li, Doctor 84013229 dzmk@163.net 收起 <<
NCT01138683	Acute Decompensated Heart Fail... 展开 >>ure 收起 <<	Phase 3	Completed	-	Belgium ... 展开 >> University Hospital Ghent Ghent, Belgium 收起 <<
NCT03457324	Irritable Bowel Syndrome	Phase 2 Phase 3	Recruiting	June 30, 2020	China, Hong Kong ... 展开 >> Chinese Medicine Clinics of Hong Kong Baptist University Recruiting Hong Kong, Hong Kong, China Contact: Zhao-xiang Bian, PhD 852-34112905 bzxiang@hkbu.edu.hk China Institute of Digestive Disease, The Chinese University of Hong Kong Not yet recruiting Hong Kong, China Contact: Justin Wu, M.D 2632 3524 justinwu@cuhk.edu.hk 收起 <<
NCT01206283	Brain Injuries ... 展开 >> Subarachnoid Hemorrhage 收起 <<	Not Applicable	Completed	-	Bosnia and Herzegovina ... 展开 >> Department of Neurosurgery, Clinical Centre University of Sarajevo Sarajevo, Bosnia and Herzegovina, 71000 收起 <<
NCT02515838	Sickle-Cell Disease	Phase 2	Recruiting	March 2019	Bahrain ... 展开 >> Salmaniya Hospital, Kingdom of Bahrain Recruiting Manama, Bahrain Contact: Dr Najat Mahdi, MD Salmaniya Medical Complex, Bahrain Recruiting Manama, Bahrain Contact: Dr. Mohamed Hassan Nafea, MD Jamaica Annotto Bay Hospital Completed Annotto Bay, Jamaica Kingston Public Hospital Completed Kingston, Jamaica University Hospital of the West Indies Completed Kingston, Jamaica Winchester Surgical and Medical Institute Completed Kingston, Jamaica Mandeville Regional Hospital Completed Mandeville, Jamaica May Pen Public Hospital Clarendon Completed May Pen, Jamaica Cornwall Regional Hospital, Jamaica Completed Montego Bay, Jamaica Lebanon American University of Beirut Medical Center, Beirut, Cairo street, Beirut, Lebanon Recruiting Beirut, Lebanon Contact: Dr Miguel Abboud, MD Nini Hospital Recruiting Tripoli, Lebanon Contact: Dr. Adlette Inati, MD Netherlands Dept of Haematology Recruiting Amsterdam, Netherlands Contact: Dr. Bart J Biemond, MD PhD Erasmus MC Completed Rotterdam, Netherlands Oman Sultan Qaboos University Hospital Alkhodh, Oman Recruiting Muscat, Oman Contact: Prof. Yasser Wali, MD Sultan Qaboos University Recruiting Muscat, Oman Contact: Dr. Murtadha Al-Khabori , MD Saudi Arabia King Fahd Medical City, As Sulimaniyah, Riyadh Saudiarabien Recruiting Riyadh, Saudi Arabia Contact: Alaa Morsi, MD King Saud University, Riyadh, Saudiarabien Recruiting Riyadh, Saudi Arabia Contact: Rahman Al Sultan, MD Turkey Mersin University Faculty of Medicine Recruiting Adana, Mersin, Turkey Contact: Dr. Anıl Tombak, MD Cukurova University Faculty Of Medicine Tıp Fakültesi Recruiting Adana, Turkey Contact: Prof. Yurdanur Kilinc, MD Dr Antmen Recruiting Adana, Turkey Contact: Dr Antmen, MD 收起 <<
NCT01829581	-		Completed	-	-
NCT01959009	Respiratory Distress Syndrome,... 展开 >> Newborn Bronchopulmonary Dysplasia Ventilator Induced Lung Injury 收起 <<	Not Applicable	Active, not recruiting	June 2018	Denmark ... 展开 >> Department of Neonatology, Rigshospitalet Copenhagen, Denmark, 2100 收起 <<
NCT01825057	See One Do On... 展开 >>e Order One 收起 <<	Phase 4	Unknown	June 2017	United States, Connecticut ... 展开 >> Yale School of Medicine New Haven, Connecticut, United States, 06511 收起 <<
NCT01582360	-		Unknown	January 2018	Norway ... 展开 >> Oslo University Hospital Recruiting Oslo, Norway Principal Investigator: Elin Helset, MD PhD Principal Investigator: Jan Fr Bugge, MD PhD Principal Investigator: Hilde Ma Sporsem, cand pharm Principal Investigator: Yvonne Lao, cand pharm Principal Investigator: Kirsti Andersson, MD 收起 <<
NCT00288665	Acute Myocardial Infarction ... 展开 >> Ventricular Remodeling 收起 <<	Phase 4	Completed	-	Netherlands ... 展开 >> St Antonius Hospital Nieuwegein, Netherlands, 3435CM 收起 <<
NCT01955785	Traumatic Brain Injury	Not Applicable	Completed	-	Norway ... 展开 >> Dept Intensive Care Medicine, St Olavs University Hospital Trondheim, Norway, 7006 收起 <<
NCT03433690	High Intensity Interval Traini... 展开 >>ng Child Obesity 收起 <<	Not Applicable	Completed	-	-
NCT02569385	-		Unknown	August 2016	Germany ... 展开 >> University Hospital RWTH Aachen, Department of Medical Clinic I Recruiting Aachen, 52074, Germany Principal Investigator: Michael Dreher, MD Sub-Investigator: Johannes Bickenbach, MD 收起 <<
NCT00910195	Obstructive Sleep Apnea	Not Applicable	Completed	-	Germany ... 展开 >> Wissenschaftliches Institut Bethanien e.V. Solingen, NRW, Germany, 42699 收起 <<
NCT03216044	-		Completed	-	-
NCT01442168	Malaria, Falciparum	Phase 1 Phase 2	Terminated	-	Thailand ... 展开 >> Mae Ramat Hospital Mae Ramat, Tak province, Thailand Maesot General hospital Mae Sot, Tak Province, Thailand Hospital for Tropical Diseases Bangkok, Thailand 收起 <<
NCT02907879	-		Recruiting	February 2020	Switzerland ... 展开 >> Department of Neurosurgery, University Hospital Bern Recruiting Bern, Switzerland, 3010 Contact: Jürgen Beck, MD 031 632 2409 juergen.beck@insel.ch Contact: Werner Z`Graggen, MD 031 632 2409 werner.zgraggen@insel.ch Principal Investigator: Jürgen Beck, MD Sub-Investigator: Werner Z`Graggen, MD 收起 <<
NCT03411746	-		Recruiting	July 31, 2019	Italy ... 展开 >> Rosanna Vaschetto Recruiting Novara, Italy, 28100 Contact: Rosanna Vaschetto, Professor +393342724811 rosanna.vaschetto@med.uniupo.it 收起 <<
NCT00317213	Smoking	Phase 2	Completed	-	Israel ... 展开 >> Arazi Clinic and Modus Clinic Tel-Aviv and Rehovot, Israel 收起 <<
NCT00000280	Cocaine-Related Disorders	Phase 1	Completed	-	United States, Connecticut ... 展开 >> VA Connecticut Healthcare System New Haven, Connecticut, United States, 06519 收起 <<
NCT02983396	Chest Pain ST... 展开 >> Elevation Myocardial Infarction 收起 <<	Not Applicable	Unknown	October 2017	Belgium ... 展开 >> Algemeen Ziekenhuis Sint-Jan Brugge Recruiting Brugge, Belgium, 8000 Contact: Yves Vandekeckhove, MD University Hospital Ghent Recruiting Ghent, Belgium, 9000 Contact: Yves taeymans, MD, Phd AZ Sint Nikolaas Recruiting St. Niklaas, Belgium, 9100 Contact: Joeri Voet, MD 收起 <<
NCT03150524	Reversible Cerebral Vasoconstr... 展开 >>iction Syndrome 收起 <<	Phase 4	Recruiting	May 31, 2019	United States, Maryland ... 展开 >> Johns Hopkins Bayview Medical Center Recruiting Baltimore, Maryland, United States, 21210 Contact: Elisabeth B Marsh, MD 410-550-8703 ebmarsh@jhmi.edu Contact: Rafael H Llinas, MD 410-550-1042 rllinas@jhmi.edu Johns Hopkins Hospital Recruiting Baltimore, Maryland, United States, 21287 Contact: Elisabeth B Marsh, MD 410-550-8703 ebmarsh@jhmi.edu Contact: Rafael H Llinas, MD 410-550-1042 rllinas@jhmi.edu 收起 <<
NCT00814658	Dementia	Phase 4	Completed	-	-
NCT01962818	Respiratory Distress Syndrome ... 展开 >>In Premature Infants Bronchopulmonary Dysplasia Ventilator-Induced Lung Injury Functional Residual Capacity 收起 <<	Not Applicable	Active, not recruiting	July 2019	Australia, Queensland ... 展开 >> Department of Neonatology, Mater Mothers Hospital Brisbane, Queensland, Australia, 4101 收起 <<
NCT00814658	-		Completed	-	-
NCT02165644	Acute Cerebrovascular Accident... 展开 >> Vasospasm 收起 <<	Phase 2	Withdrawn(The PI is leaving th... 展开 >>e University of Florida.) 收起 <<	-	-
NCT03028090	-		Completed	-	United States, Colorado ... 展开 >> Memorial Health System Colorado Springs, Colorado, United States, 80909 United States, Ohio Bethesda North Hospital Montgomery, Ohio, United States, 45242 收起 <<
NCT00004399	Pre-eclampsia	Not Applicable	Completed	-	-
NCT03288766	-		Recruiting	January 2019	United States, North Carolina ... 展开 >> Vidant Medical Center Recruiting Greenville, North Carolina, United States, 27834 Contact: Connie Rogers, ADN CRogers@vidanthealth.com 收起 <<
NCT02991157	-		Active, not recruiting	December 2018	India ... 展开 >> NIMHANS Bengaluru, India 收起 <<
NCT00000332	Cocaine-Related Disorders	Phase 2	Completed	-	United States, District of Col... 展开 >>umbia Washington DC VA Washington, District of Columbia, United States, 20422 收起 <<
NCT00781326	Depression	Phase 4	Terminated(Final cost of study... 展开 >> medication was significantly greater than initial estimate,) 收起 <<	-	United States, Pennsylvania ... 展开 >> University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15213 收起 <<
NCT03228498	Vascular Cognitive Impairment	Phase 2	Recruiting	September 1, 2019	Italy ... 展开 >> Stroke Unit, VAS-COG clinic, Azienda Ospedaliero Universitaria Careggi Recruiting Firenze, Italy, 50134 Contact: Leonardo Pantoni, MD, PhD +39-055-2751897 leonardo.pantoni@unifi.it Sub-Investigator: Anna Poggesi, MD, PhD 收起 <<
NCT00000738	AIDS Dementia Complex ... 展开 >> HIV Infections 收起 <<	Phase 1	Completed	-	United States, California ... 展开 >> UCLA CARE Center CRS Los Angeles, California, United States, 90095 United States, Illinois Northwestern University CRS Chicago, Illinois, United States, 60611 United States, Indiana Indiana Univ. School of Medicine, Infectious Disease Research Clinic Indianapolis, Indiana, United States, 46202 United States, Massachusetts Massachusetts General Hospital ACTG CRS Boston, Massachusetts, United States, 02114 Bmc Actg Crs Boston, Massachusetts, United States, 02118 Beth Israel Deaconess - East Campus A0102 CRS Boston, Massachusetts, United States, 02215 United States, Minnesota University of Minnesota, ACTU Minneapolis, Minnesota, United States, 55455 United States, Missouri Washington U CRS St. Louis, Missouri, United States United States, New York Univ. of Rochester ACTG CRS Rochester, New York, United States, 14642 United States, North Carolina Unc Aids Crs Chapel Hill, North Carolina, United States, 27599 United States, Ohio Case CRS Cleveland, Ohio, United States, 44106 United States, Washington University of Washington AIDS CRS Seattle, Washington, United States 收起 <<
NCT02248233	Cerebral Infarction	Phase 4	Completed	-	-
NCT02893826	Subarachnoid Hemorrhage, Aneur... 展开 >>ysmal 收起 <<	Phase 1	Terminated(Based on DMC recomm... 展开 >>endation to discontinue EG-01-1962-03) 收起 <<	-	United States, Arizona ... 展开 >> Dignity Health; St. Joseph's Hospital and Medical Center Phoenix, Arizona, United States, 85013 United States, California University of California San Francisco San Francisco, California, United States, 94143 United States, Maryland University of Maryland Medical Systems Baltimore, Maryland, United States, 21201 Canada, Alberta University of Alberta Hospital/Mackenzie Health Sciences Centre Edmonton, Alberta, Canada, T6G 2B7 收起 <<
NCT00781326	-		Terminated(Final cost of study... 展开 >> medication was significantly greater than initial estimate,) 收起 <<	-	-
NCT01220622	Stroke Mild C... 展开 >>ognitive Impairment 收起 <<	Phase 4	Unknown	July 2012	China ... 展开 >> Beijing Tian Tan Hospital, Capital Medical University Recruiting Beijing, China Contact: Feng tao, M.D. 00861067098343 happyft@sina.com Contact: Wang xuemei, M.D. minnie_wxm@hotmail.com 收起 <<
NCT01893190	Ruptured Cerebral Aneurysm ... 展开 >> Ruptured Berry Aneurysm 收起 <<	Phase 1 Phase 2	Completed	-	-
NCT01672801	Unexplained Infertility ... 展开 >> Polycystic Ovarian Syndrome Anovulatory 收起 <<	Not Applicable	Completed	-	United States, Massachusetts ... 展开 >> Boston IVF Waltham, Massachusetts, United States, 02451 收起 <<
NCT02537080	Mild Cognitive Impairment	Not Applicable	Terminated(higher POCD in nimo... 展开 >>dipine Group) 收起 <<	December 2017	Czech Republic ... 展开 >> University Hospital Hradec Kralove, Czech Republic, 50005 收起 <<
NCT02790632	Subarachnoid Hemorrhage, Aneur... 展开 >>ysmal 收起 <<	Phase 3	Terminated(DMC review conclude... 展开 >>d study has a low probability of meeting its primary endpoint) 收起 <<	-	-
NCT01551368	Infertility	Phase 2	Terminated(small number of pat... 展开 >>ients got recruited) 收起 <<	July 2017	Canada, Ontario ... 展开 >> Toronto Centre for Advanced reproductive Technology (TCART) Toronto, Ontario, Canada, M5S2X9 收起 <<
NCT03671525	Schizophrenia ... 展开 >> Schizo Affective Disorder 收起 <<	Early Phase 1	Recruiting	October 2019	United States, Maryland ... 展开 >> Johns Hopkins Bayview Medical Center Recruiting Baltimore, Maryland, United States, 21224 Contact: Frederick Nucifora, M.D Johns Hopkins University Not yet recruiting Baltimore, Maryland, United States, 21287 收起 <<
NCT01835665	Progranulin Mutation Carriers	Phase 1	Completed	-	United States, California ... 展开 >> UCSF Memory and Aging Center San Francisco, California, United States, 94158 收起 <<

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