Tolperisone hydrochloride is a centrally acting muscle relaxant, is indicated for use in the treatment of pathologically increased tone of the cross-striated muscle caused by neurological diseases (damage of the pyramidal tract, multiple sclerosis, myelopathy, encephalomyelitis) and of spastic paralysis and other encephalopathies manifested with muscular dystonia[3]. The prophylactic intake of tolperisone hydrochloride provides no relief to pain in course of post-exercise muscle soreness but results in reduction in isometric force[4]. Tolperisone inhibited the spontaneous movement and methamphetamine-induced hyperactivity in mice and the ED50 was approx. 50 mg/kg, s.c. Tolperisone inhibited convulsions induced by pentylenetetrazol, nicotine and maximum electric shock, but did not affect convulsions induced by strychnine and picrotoxin. Tolperisone induced muscle relaxation in mice and rats in several pharmacological tests, but did not affect neuro-muscular transmission. Tolperisone reduced decerebrated rigidity in cats with i.v. administration of 5 approximately 10 mg/kg and intraduodenal administration of 50 approximately 100 mg/kg[5]. Moreover, Tolperisone-HCl (5-10 mg/kg, i.v.) and baclofen (1-3 mg/kg, i.v.) decreased the number of post-rotatory nystagmus beats dose-dependently[6]. Tolperisone (2.5-10 mg/kg) dose-dependently inhibited both ventral root reflexes and the dorsal root reflex. It slightly prolonged the dorsal root potential without affecting the amplitude[7].
United States, California
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Southern California Clinical Research, Inc.
Pasadena, California, United States, 91106
United States, Florida
University of Miami Miller School of Medicine
Miami, Florida, United States, 33136
United States, Georgia
Shepherd Center, Inc.
Atlanta, Georgia, United States, 30309
United States, Maryland
Internal Center for Spinal Cord Injury Kennedy Kreiger Institute
Baltimore, Maryland, United States, 21205
Kernan Orthopaedics & Rehab. Hospital
Baltimore, Maryland, United States, 21207
United States, New Jersey
Kessler Institute for Rehab.
West Orange, New Jersey, United States, 07052
United States, North Carolina
Carolinas Rehabilitation
Charlotte, North Carolina, United States, 28203
United States, Pennsylvania
Jefferson Medical College of Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
United States, Virginia
Hunter Holmes McGuire Veterans Affairs Medical Center
Richmond, Virginia, United States, 23249
Canada, Quebec
Rehabilitation Hospital Health Sciences Centre
Winnipeg, Quebec, Canada, R3A 1M4 收起 <<
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Collaborative Neuroscience Network
Long Beach, California, United States, 92845
United States, Georgia
NeuroTrials Research
Atlanta, Georgia, United States, 30342 收起 <<
United States, California
... 展开 >>
Southern California Clinical Research, Inc.
Pasadena, California, United States, 91106
United States, Florida
University of Miami Miller School of Medicine
Miami, Florida, United States, 33136
United States, Georgia
Shepherd Center, Inc.
Atlanta, Georgia, United States, 30309
United States, Maryland
Internal Center for Spinal Cord Injury Kennedy Kreiger Institute
Baltimore, Maryland, United States, 21205
Kernan Orthopaedics & Rehab. Hospital
Baltimore, Maryland, United States, 21207
United States, New Jersey
Kessler Institute for Rehab.
West Orange, New Jersey, United States, 07052
United States, North Carolina
Carolinas Rehabilitation
Charlotte, North Carolina, United States, 28203
United States, Pennsylvania
Jefferson Medical College of Thomas Jefferson University
Philadelphia, Pennsylvania, United States, 19107
United States, Virginia
Hunter Holmes McGuire Veterans Affairs Medical Center
Richmond, Virginia, United States, 23249
Canada, Quebec
Rehabilitation Hospital Health Sciences Centre
Winnipeg, Quebec, Canada, R3A 1M4 收起 <<
United States, California
... 展开 >>
Collaborative Neuroscience Network
Long Beach, California, United States, 92845
United States, Georgia
NeuroTrials Research
Atlanta, Georgia, United States, 30342 收起 <<
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