Mexiletine is an orally effective antiarrhythmic agent noted for its benefits in treating myotonia and neuropathic pain. It operates by inhibiting sodium channels, with an IC50 of 75±8 μM for tonic block and 23.6±2.8 μM for use-dependent block, making it relevant for both cardiovascular and neurological research[1].[2].[3].[4].[5].
体内研究
Additionally, Mexiletine (30, 100 mg/kg, p.o., acutely administered) effectively counteracts mechanical allodynia and cold hyperalgesia in rats induced with Oxaliplatin[4].
体外研究
Mexiletine (10µM, 48 h) enhances both peak INa and late INa in HEK293A cells transfected with SCN5A-WT or SCN5A-1795insD, while a shorter exposure (10µM, 5 min) inhibits the late INa[3].
Netherlands
... 展开 >> Departments of Neurology, Radboud University Nijmegen Medical Centre, the Netherlands
Nijmegen, Gelderland, Netherlands, 6500HB 收起 <<
Netherlands
... 展开 >> Departments of Neurology, Radboud University Nijmegen Medical Centre, the Netherlands
Nijmegen, Gelderland, Netherlands, 6500HB 收起 <<
United States, California
... 展开 >>
UCLA, Neuromuscular Research Center
Los Angeles, California, United States, 90095
United States, Iowa
University of Iowa
Iowa City, Iowa, United States, 52242
United States, Kansas
University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
United States, Massachusetts
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
University of Massachusetts (Worcester) Memorial Medical Center
Worcester, Massachusetts, United States, 01655
United States, Missouri
Washington University Medical School
Saint Louis, Missouri, United States, 63110
United States, New York
SUNY Upstate Medical Center
Syracuse, New York, United States, 13210
United States, Pennsylvania
Penn State Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
United States, Texas
University of Texas Southwestern Medical Center at Dallas
Dallas, Texas, United States, 75390-8897
United States, Washington
University of Washington Medical Center
Seattle, Washington, United States, 98195 收起 <<
United States, Arizona
... 展开 >>
Barrow Neurological Institute
Phoenix, Arizona, United States, 85013
United States, California
University of California, Irvine
Orange, California, United States, 92868
United States, Georgia
Augusta University
Augusta, Georgia, United States, 30912
United States, Massachusetts
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
United States, Michigan
University of Michigan
Ann Arbor, Michigan, United States, 48109
United States, New York
Columbia Universtiy Medical Center
New York, New York, United States, 10032
United States, Pennsylvania
Pennsylvania State Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
United States, South Carolina
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
United States, Washington
University of Washington
Seattle, Washington, United States, 98195 收起 <<
搜索
