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匹维溴铵 /Pinaverium bromide {[allProObj[0].p_purity_real_show]}

货号：A217245 同义名： Icosapentaenoic acid

Pinaverium bromide acts as a calcium channel blocker in helping to restore the normal contraction process of the bowel.

Pinaverium bromide 化学结构 CAS号：53251-94-8
Pinaverium bromide 化学结构
CAS号：53251-94-8
Pinaverium bromide 3D分子结构
CAS号：53251-94-8
Pinaverium bromide 化学结构 CAS号：53251-94-8
Pinaverium bromide 3D分子结构 CAS号：53251-94-8
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Pinaverium bromide 纯度/质量文件 产品仅供科研

货号：A217245 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 Ca2+ channel-like protein ↓ Calcium Channel ↓ Cav 2.2 ↓ 其他靶点 纯度
CDC25B-IN-2 ✔ Akt 99%+
Clevidipine ✔ 97%
Verapamil HCl ✔ 99%
Amlodipine ✔ 99%
Amlodipine maleate ✔ 98%
(+)-cis-Diltiazem HCl ✔ 95%
Zegocractin ++

Orai1/STIM1-mediated Ca2+ currents, IC50: 120 nM

 		99%+
Tanshinone IIA sulfonate sodium ✔ 98%
Ulixacaltamide ++

hCaV3.1, IC50: 50 nM

hCaV3.2, IC50: 110 nM

 		99%+
Dronedarone Hydrochloride ✔ 95%
Nitrendipine +

Calcium channel, IC50: 95 nM

 		98%
Efonidipine HCl monoethanolate ✔ 98%
Cinnarizine ✔ 98%
SEA0400 ++

NCX, IC50: 33 nM

 		ROS,ERK,p38 MAPK 99%+
Fasudil HCl ✔ Rho,PKA 98%
ML-9 ✔ Akt,MLCK 99%+
Flunarizine 2HCl +

Calcium channel, Ki: 68 nM

 		95%
Lomerizine 2HCl ✔ 98%
Efonidipine ✔ 98%
Levamlodipine ✔ 97%
Nisoldipine ++

L-type Cav1.2, IC50: 10 nM

 		97%
Isradipine ✔ 98%
Lacidipine ✔ 98%
Lercanidipine ✔ 98%
Loureirin B ✔ Potassium Channel 99%+
Tetracaine HCl ✔ 98%
Manidipine +++

Calcium channel, IC50: 2.6 nM

 		98%
Manidipine Dihydrochlorid +++

Calcium channel, IC50: 2.6 nM

 		98%
Nicardipine ✔ 98%
Wilforgine ✔ 98+%
Econazole ✔ 99%+
Ginsenoside Rd ✔ NF-κB 98%
Fendiline HCl ✔ 98+%
Mesaconitine ✔ 98%
Tetrandrine ✔ 95%
Nifedipine ✔ 95%
Nilvadipine ++++

Calcium channel, IC50: 0.03 nM

 		98%
Barnidipine ++++

[3H]nitrendipine, Ki: 0.21 nM

 		95+%
Azelnidipine ✔ 97%
Levetiracetam ✔ 98%
Nimodipine ✔ 95%
Benidipine HCl ✔ 98%
Pinaverium bromide ✔ 98%
Pranidipine ✔ 98%
NP118809 +

N-type Ca2+ channel, IC50: 0.11 μM

L-type calcium channel, IC50: 12.2 μM

 		98%
Amlodipine Besylate +++

Calcium channel, IC50: 1.9 nM

 		97%
Cilnidipine ✔ 98%
Cinepazide Maleate ✔ 98%
Terfenadine ✔ 98%
YM-58483 ✔ 99%+
Ranolazine ✔ 98%
Praeruptorin A ✔ Akt,p38 MAPK 98%
Ranolazine 2HCl ✔ 98%
Felodipine ++++

L-type calcium channel, IC50: 0.15 nM

 		98%
PD173212 +++

N-type Ca2+ channel, IC50: 36 nM

 		98%
Levamlodipine besylate ✔ 97%
Carboxyamidotriazole Orotate ✔ 98%
IGS-1.76 ✔ 98+%
WH-4-023 ++++

Cav 2.2, IC50: 0.001 μM

 		++++

Cav 2.2, IC50: 0.001 μM

 		99%+
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Pinaverium bromide 生物活性

靶点

  • Calcium Channel
描述 Pinaverium bromide acts as a calcium channel blocker in helping to restore the normal contraction process of the bowel.

Pinaverium bromide 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01641224 Irritable Bowel Syndrome Not Applicable Unknown May 2014 China, Jiangsu ... 展开 >> Second Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210017 Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210029 China Beijing Xuanwu Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Beijing, China, 100050 Shanghai First People's Hospital affiliated to Shanghai Tiao Tong University Shanghai, China, 200240 收起 <<
NCT02330029 Irritable Bowel Syndrome Not Applicable Unknown May 2017 China, Jiangsu ... 展开 >> Second Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210017 Jiangsu Provincial Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Traditional Chinese Medicine Nanjing, Jiangsu, China, 210029 China Beijing Xuanwu Hospital of Traditional Chinese Medicine affiliated to Capital Medical University. Beijing, China, 100050 Shanghai First People's Hospital affiliated to Shanghai Tiao Tong University Shanghai, China, 200240 收起 <<
NCT01678781 - Completed - China ... 展开 >> Site reference ID/Investigator# 94519 Beijing, China, 100034 Site reference ID/Investigator# 95475 Guangzhou City, China, 510515 Site reference ID/Investigator# 94521 Guangzhou, China, 510080 Site reference ID/Investigator # 94518 Shanghai, China, 200127 Site reference ID/Investigator # 94517 Shanghai, China, 200433 Site reference ID/Investigator # 94516 Shanghai, China Site reference ID/Investigator # 94515 Wuhan, China, 430022 Egypt Site Reference ID/Investigator# 95908 Alexandria, Egypt Site reference ID/Investigator# 95900 Cairo, Egypt Site reference ID/Investigator# 95901 El Sharkya, Egypt Site reference ID/Investigator# 95902 Giza, Egypt Site reference ID/Investigator# 95903 Giza, Egypt Site Reference ID/Investigator# 95906 Port Said, Egypt Mexico Site reference ID/Investigaot# 94525 Guadalajara, Mexico, 49000 Site refernce ID/Investigator# 94527 Mexico City, Mexico, 54055 Site reference ID/Investigator# 94523 Tampico, Mexico, 89190 Poland Site reference ID/Investigator# 85314 Bialystok, Poland, 15-270 Site Reference ID/Investigator# 85297 Bialystok, Poland, 15-351 Site Reference ID/Investigator# 85298 Bydgoszcz, Poland, 85-079 Site Reference ID/Investigator# 85293 Katowice, Poland, 40-031 Site Reference ID/Investigator# 85296 Lodz, Poland, 91-473 Site reference ID/Investigator# 85313 Olsztyn, Poland, 10-501 Site Reference ID/Investigator# 85295 Poznan, Poland, 60-193 Site Reference ID/Investigator# 85294 Poznan, Poland, 60-539 收起 <<

Pinaverium bromide 参考文献

[1]Dai Y, Liu JX, et al. Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World J Gastroenterol. 2003 Mar;9(3):557-61.

[2]Boyer JC, Magous R, et al. Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide. Cell Calcium. 2001 Jun;29(6):429-38.

Pinaverium bromide 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.45mL

1.69mL

0.85mL

16.91mL

3.38mL

1.69mL

Pinaverium bromide 技术信息

CAS号53251-94-8
分子式C26H41Br2NO4
分子量 591.416
别名 Icosapentaenoic acid
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature
溶解度

DMSO: 50 mg/mL(84.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 10 mg/mL(16.91 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方

Tags: Pinaverium | 53251-94-8 | Calcium Channel | Ca2+ channels | Calcium Channel Inhibitor | Membrane Transporter/Ion Channel | Neuronal Signaling | Calcium Channel | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Pinaverium bromide 纯度/质量文件 | Pinaverium bromide 亚型比较 | Pinaverium bromide 生物活性 | Pinaverium bromide 临床数据 | Pinaverium bromide 参考文献 | Pinaverium bromide 实验方案 | Pinaverium bromide 技术信息

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